Target Details
| UniProt AC | P04141 |
|---|---|
| Gene Symbol | CSF2 |
| Protein Name | Granulocyte-macrophage colony-stimulating factor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01109 (GM_CSF) |
Summary
- Multi-target molecules 4
- Clinical molecules 0
- Avg pChEMBL 7.53
KEGG Pathways (16)
- Acute myeloid leukemia
- Amoebiasis
- Coronavirus disease - COVID-19
- Cytokine-cytokine receptor interaction
- Fc epsilon RI signaling pathway
- Hematopoietic cell lineage
- Human T-cell leukemia virus 1 infection
- IL-17 signaling pathway
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Natural killer cell mediated cytotoxicity
- Rheumatoid arthritis
- Shigellosis
- T cell receptor signaling pathway
- TNF signaling pathway
- Transcriptional misregulation in cancer
Active Molecules (4)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IXZOHGPZAQLIBH
|
8.7 | IC50 | 8 | — | |
IXZOHGPZAQLIBH
|
8.0 | IC50 | 6 | — | |
IXZOHGPZAQLIBH
|
7.4 | IC50 | 6 | — | |
RSNPAKAFCAAMBH
|
6.0 | IC50 | 8 | — |