Target Details
| UniProt AC | P04049 |
|---|---|
| Gene Symbol | RAF1 |
| Protein Name | RAF proto-oncogene serine/threonine-protein kinase |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF07714 (PK_Tyr_Ser-Thr) PF02196 (RBD) |
Summary
- Multi-target molecules 2,133
- Clinical molecules 20
- Avg pChEMBL 8.1
KEGG Pathways (84)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin signaling pathway
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Tuberculosis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (2,133)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QPOWGPGOTGCBQP
|
9.3 | IC50 | 2 | — | |
RFCKZYSSGBSRJL
|
9.3 | IC50 | 2 | — | |
RINDPRPVBOGYGN
|
9.3 | IC50 | 2 | — | |
RPWFLXNBYHEIQO
|
9.3 | IC50 | 2 | — | |
UDHXRVPPXWJDAN
|
9.3 | IC50 | 2 | — | |
UFSSCDAODYJAIS
|
9.3 | IC50 | 2 | — | |
USCMQZYHWRMJCB
|
9.3 | IC50 | 2 | — | |
USDDJVQBULIBKZ
|
9.3 | IC50 | 2 | — | |
USDMDPVBQZBXEU
|
9.3 | IC50 | 2 | — | |
UWPBXWOCFRZZEJ
|
9.3 | IC50 | 2 | — | |
VXZYBHGVCJHBFW
|
9.3 | IC50 | 2 | — | |
WCSQDCPCGRYUND
|
9.3 | IC50 | 2 | — | |
WUHCLCRCBCBJQT
|
9.3 | IC50 | 2 | — | |
XIEGUNPXGANEIU
|
9.3 | IC50 | 2 | — | |
YMLMZIAYGCZUDE
|
9.3 | IC50 | 2 | — | |
YXARVHZXTQVAOP
|
9.3 | IC50 | 11 | — | |
ZKANYWMNLVXDMU
|
9.3 | IC50 | 2 | — | |
ZMPLUUUXFORXDW
|
9.3 | IC50 | 2 | — | |
AAKDISFYBVCWAI
|
9.3 | IC50 | 2 | — | |
AIPRPSWGJJAMMI
|
9.3 | IC50 | 2 | — | |
RVPQVKRCGLMTMT
|
9.3 | IC50 | 2 | — | |
UFJILEUJRRXOHJ
|
9.3 | IC50 | 2 | — | |
WIXHYXLSQXWVLT
|
9.3 | IC50 | 2 | — | |
XNRCMJSJCGGCPC
|
9.3 | IC50 | 2 | — | |
DDSNJNSZZOOAAH
|
9.3 | IC50 | 2 | — | |
KIBYUDYZOOXCSS
|
9.3 | IC50 | 2 | — | |
LPOXCHABLAZUHB
|
9.3 | IC50 | 3 | — | |
MFAFOSJZKZAZSS
|
9.3 | IC50 | 2 | — | |
WMUYNQKBTHBDDB
|
9.3 | IC50 | 2 | — | |
ZAPJTTHBHRSAGS
|
9.3 | IC50 | 2 | — | |
FOLVBVJHOLIIRE
|
9.3 | IC50 | 2 | — | |
VUZCEFIOTAPEKC
|
9.3 | IC50 | 2 | — | |
VUZCEFIOTAPEKC
|
9.3 | IC50 | 2 | — | |
CMIJHFNTDXDDTO
|
9.3 | IC50 | 2 | — | |
GGGFTTMBYHTHTO
|
9.3 | IC50 | 2 | — | |
KVWUPLZRKBYTGG
|
9.3 | IC50 | 2 | — | |
JYESOJFCWIWKCG
|
9.2 | IC50 | 2 | — | |
LDTUEQNAYCVAAO
|
9.2 | IC50 | 2 | — | |
NMGUFZZZFPOLHX
|
9.2 | IC50 | 2 | — | |
VTHKEBCGQBGYOT
|
9.2 | IC50 | 2 | — | |
GJZPUXPLFRPKSX
|
9.2 | IC50 | 2 | — | |
GMYDKQWTIUVCNT
|
9.2 | IC50 | 2 | — | |
JVJGDEKMUWPKOW
|
9.2 | IC50 | 2 | — | |
LZGGFVXWAVXQLA
|
9.2 | IC50 | 2 | — | |
UDUXYHUWFANFEJ
|
9.2 | IC50 | 2 | — | |
ZNVCVMODGVQVMO
|
9.2 | IC50 | 2 | — | |
CMTVLOPAPBQCRJ
|
9.2 | IC50 | 2 | — | |
UOSJJLNSEIPARI
|
9.2 | IC50 | 2 | — | |
AEJACXAFHXBVHF
|
9.2 | IC50 | 2 | — | |
AIUCDYHYCNUTCD
|
9.2 | IC50 | 2 | — |