Target Details
| UniProt AC | P04049 |
|---|---|
| Gene Symbol | RAF1 |
| Protein Name | RAF proto-oncogene serine/threonine-protein kinase |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF07714 (PK_Tyr_Ser-Thr) PF02196 (RBD) |
Summary
- Multi-target molecules 2,133
- Clinical molecules 20
- Avg pChEMBL 8.1
KEGG Pathways (84)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin signaling pathway
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Tuberculosis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (2,133)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NRJWTGFPQAYOOI
|
6.8 | IC50 | 2 | — | |
ZTXBULQXSIEEHP
|
6.8 | IC50 | 2 | — | |
LSFNHAFZZXYIDB
|
6.8 | IC50 | 2 | — | |
IYQPENHNLZPWEI
|
6.8 | IC50 | 2 | — | |
NLVDXVNGRDBBHC
|
6.8 | IC50 | 2 | — | |
SVJXCDPMCSOTJX
|
6.8 | IC50 | 2 | — | |
PBZIVNRGIYOENS
|
6.8 | IC50 | 2 | — | |
KLYLLRQQDAMWTR
|
6.8 | IC50 | 2 | — | |
RBTJBGVGWLFOLY
|
6.8 | IC50 | 2 | — | |
WJVCASAEBZAPDS
|
6.8 | IC50 | 2 | — | |
ACVWWDRVNBIHJC
|
6.8 | IC50 | 2 | — | |
KNHDWAHCQKUXFX
|
6.8 | IC50 | 2 | — | |
OEDDQSURBHYSLH
|
6.8 | IC50 | 2 | — | |
DVLXULKETFKWBZ
|
6.8 | IC50 | 4 | — | |
GJCOFIVXYUMIQK
|
6.8 | IC50 | 2 | — | |
GQDIEXXTSJEMLK
|
6.8 | IC50 | 2 | — | |
WMVXSEQUHAGMDB
|
6.8 | IC50 | 3 | — | |
DUAGJVFSWKNHNE
|
6.8 | IC50 | 2 | — | |
MNYNMCHVIOLYGI
|
6.8 | IC50 | 2 | — | |
XVUHBENWLBKIMX
|
6.8 | IC50 | 2 | — | |
ADBKOQIERJLCFF
|
6.8 | IC50 | 2 | — | |
DTHMVQCNWFKXRR
|
6.8 | IC50 | 2 | — | |
CIAWTKNWINEPQJ
|
6.7 | IC50 | 2 | — | |
JJFGIVDPFSSOMH
|
6.7 | IC50 | 2 | — | |
MKMYAVUUMSCFQQ
|
6.7 | IC50 | 4 | Yes | |
MLGNXKIPPIXQET
|
6.7 | IC50 | 2 | — | |
YHLSUBLOJXHKMY
|
6.7 | IC50 | 2 | — | |
CTKKHIGWHWTBQS
|
6.7 | IC50 | 2 | — | |
OGRKOMKPSIJMLN
|
6.7 | IC50 | 2 | — | |
UAJMVGKWALBKMO
|
6.7 | IC50 | 2 | — | |
WMZIJTPQPPPLHI
|
6.7 | Kd | 2 | — | |
XCCAOVJRURGDKW
|
6.7 | Kd | 2 | — | |
NHCJCHFTBCCHIX
|
6.7 | IC50 | 2 | — | |
QFPAMUZIRWPPKB
|
6.7 | IC50 | 2 | — | |
SUBDZIRWBNUWKU
|
6.7 | IC50 | 2 | — | |
WMXJYEDCJIDCNY
|
6.7 | IC50 | 2 | — | |
YLQMVIRZBOJBCV
|
6.7 | IC50 | 7 | Yes | |
GEYLKEHPEKRUTC
|
6.7 | IC50 | 7 | — | |
CYCXCKOESWCLST
|
6.7 | IC50 | 5 | — | |
GTKJOUZHAZVXFH
|
6.7 | IC50 | 2 | — | |
IXNBXNMYYSMTJZ
|
6.7 | IC50 | 2 | — | |
ISLCYYCODRRXHY
|
6.7 | IC50 | 2 | — | |
NSDPPHUZHNFMPM
|
6.7 | IC50 | 2 | — | |
FXXREISGAMJGMI
|
6.7 | IC50 | 2 | — | |
GHEKKLAAPQPHPZ
|
6.7 | IC50 | 2 | — | |
UVFPAUPHTITLLA
|
6.7 | IC50 | 2 | — | |
VWMJHAFYPMOMGF
|
6.7 | IC50 | 15 | — | |
GBKYUTIMIIUUJY
|
6.7 | IC50 | 2 | — | |
OTASYYGEHSXRJI
|
6.6 | IC50 | 3 | — | |
XKNAGLMNQADBQE
|
6.6 | IC50 | 2 | — |