Target Details
| UniProt AC | P04049 |
|---|---|
| Gene Symbol | RAF1 |
| Protein Name | RAF proto-oncogene serine/threonine-protein kinase |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF07714 (PK_Tyr_Ser-Thr) PF02196 (RBD) |
Summary
- Multi-target molecules 2,133
- Clinical molecules 20
- Avg pChEMBL 8.1
KEGG Pathways (84)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin signaling pathway
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Tuberculosis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (2,133)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ACXODBAODQZCHM
|
7.0 | IC50 | 2 | — | |
ADPVMTPAEZGGRY
|
7.0 | IC50 | 2 | — | |
AMXSNSOKRKFXTE
|
7.0 | IC50 | 2 | — | |
AODILZQVBWAGBQ
|
7.0 | IC50 | 2 | — | |
ARUKGTYPSXREJT
|
7.0 | IC50 | 2 | — | |
CFQMCKHVXRXETB
|
7.0 | IC50 | 2 | — | |
CHIKRNNWWQAYQA
|
7.0 | IC50 | 2 | — | |
CSAJGJCTRLXUEU
|
7.0 | IC50 | 2 | — | |
DPNNYGQHNWYCGO
|
7.0 | IC50 | 2 | — | |
DTKRFEYENYMBQZ
|
7.0 | IC50 | 2 | — | |
DZCBRTBEXDTPDC
|
7.0 | IC50 | 2 | — | |
FAYAUAZLLLJJGH
|
7.0 | IC50 | 36 | Yes | |
FHABBMMGGOBOLS
|
7.0 | IC50 | 2 | — | |
FJAJQTIULRMEMP
|
7.0 | IC50 | 2 | — | |
FJXQWUJTRJWSAP
|
7.0 | IC50 | 2 | — | |
GTFPMQAVURWRPD
|
7.0 | IC50 | 2 | — | |
GWVCKDGKNUDQHN
|
7.0 | IC50 | 2 | — | |
HGKZDQUOOVLCDL
|
7.0 | IC50 | 2 | — | |
HQDRUVLGYSBREV
|
7.0 | IC50 | 2 | — | |
HTYMDARZTPCNHJ
|
7.0 | IC50 | 2 | — | |
IHHUCXRAMDFEAC
|
7.0 | IC50 | 2 | — | |
IJPDDEXQDCSGFU
|
7.0 | IC50 | 2 | — | |
ISAYWFXFDWDBCC
|
7.0 | IC50 | 2 | — | |
IZJNTXFWJNCGNB
|
7.0 | IC50 | 2 | — | |
JVCUGVRYYKYOIK
|
7.0 | IC50 | 2 | — | |
JXPRZVYXXPOGJT
|
7.0 | IC50 | 2 | — | |
KPENLZQXTOOUMC
|
7.0 | IC50 | 2 | — | |
KRIIHSSPOMTJPP
|
7.0 | IC50 | 2 | — | |
KRJYHAVNEACZBV
|
7.0 | IC50 | 2 | — | |
KWBFBPNBNAGYQA
|
7.0 | IC50 | 2 | — | |
LCTFMYBJTAJFBD
|
7.0 | IC50 | 2 | — | |
LTSSPZVYVIFFFL
|
7.0 | IC50 | 2 | — | |
LXXHRKOQZVNECL
|
7.0 | IC50 | 2 | — | |
MGBUCHBAMDELRQ
|
7.0 | IC50 | 2 | — | |
MLSAQOINCGAULQ
|
7.0 | IC50 | 2 | — | |
MVLWJRZZBIKEEM
|
7.0 | IC50 | 2 | — | |
MWXROFUCHQSRRT
|
7.0 | IC50 | 2 | — | |
NNBYLJACBIVMDF
|
7.0 | IC50 | 2 | — | |
NQBZZTQBTGEHEM
|
7.0 | IC50 | 2 | — | |
NQIDKYDDEPOOGC
|
7.0 | IC50 | 2 | — | |
NZHHWGVDFUTQAW
|
7.0 | IC50 | 2 | — | |
ONNASYFWYZONLS
|
7.0 | IC50 | 2 | — | |
OOGSQHIRMPONOF
|
7.0 | IC50 | 2 | — | |
PLNPXRUNNRKKPG
|
7.0 | IC50 | 2 | — | |
REDSBIDCOJPLJV
|
7.0 | IC50 | 2 | — | |
RJBGBFUWDAKFSW
|
7.0 | IC50 | 2 | — | |
RWJGXHSKKVZYLI
|
7.0 | IC50 | 2 | — | |
RWZGTKNZCVARNP
|
7.0 | IC50 | 2 | — | |
SLRODZGRHFZXNW
|
7.0 | IC50 | 2 | — | |
SZEUUTNYIKHBRV
|
7.0 | IC50 | 2 | — |