Target Details
| UniProt AC | P04049 |
|---|---|
| Gene Symbol | RAF1 |
| Protein Name | RAF proto-oncogene serine/threonine-protein kinase |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF07714 (PK_Tyr_Ser-Thr) PF02196 (RBD) |
Summary
- Multi-target molecules 2,133
- Clinical molecules 20
- Avg pChEMBL 8.1
KEGG Pathways (84)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin signaling pathway
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Tuberculosis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (2,133)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CEKWCFPBLIREBY
|
8.0 | IC50 | 2 | — | |
CVPQAGYSQPJNCU
|
8.0 | IC50 | 2 | — | |
DEMGQTZMUXZFMW
|
8.0 | IC50 | 2 | — | |
GZGBJRNBGXYDNA
|
8.0 | IC50 | 2 | — | |
BNEIJRJUSPJYIW
|
8.0 | IC50 | 2 | — | |
CAEMFFVPJFULIV
|
8.0 | IC50 | 2 | — | |
DFLKCKWPMUYANV
|
8.0 | IC50 | 2 | — | |
GOMBEKULXIGEDP
|
8.0 | IC50 | 2 | — | |
LMUOLSXKQCWLAY
|
8.0 | IC50 | 2 | — | |
LYWNHHSMUZTLKZ
|
8.0 | IC50 | 2 | — | |
UMHJHEYJBGFPDL
|
8.0 | IC50 | 2 | — | |
WBAHMOJHMNNARC
|
8.0 | IC50 | 2 | — | |
ZHSZRLNZUKRCPI
|
8.0 | IC50 | 2 | — | |
ZJQYVSTVRXOFQL
|
8.0 | IC50 | 4 | — | |
ZWRBBJOOCODFQA
|
8.0 | IC50 | 2 | — | |
YJYYWWDRIBCBBQ
|
7.9 | IC50 | 2 | — | |
CBMYEWZXTJTCKW
|
7.9 | IC50 | 2 | — | |
GFMMXOIFOQCCGU
|
7.9 | IC50 | 4 | — | |
LWHCGCXCKRIJCQ
|
7.9 | IC50 | 2 | — | |
RBHVBUPFRAIYAH
|
7.9 | IC50 | 2 | — | |
RBKYGVBCBBPYMX
|
7.9 | IC50 | 2 | — | |
UYFPHIJXUONCKX
|
7.9 | IC50 | 3 | — | |
VVIXOXWAEFXJFE
|
7.9 | IC50 | 2 | — | |
GXEGTVQATHKFDH
|
7.9 | IC50 | 10 | Yes | |
TYSVHXIZTMTDBA
|
7.9 | IC50 | 2 | — | |
PGYAPWSQANKWNH
|
7.9 | IC50 | 2 | — | |
SRMCYNSAIDBEID
|
7.9 | IC50 | 2 | — | |
UNVNJAFTCKAAMY
|
7.9 | IC50 | 2 | — | |
FQTDEACKAXRSFD
|
7.9 | IC50 | 2 | — | |
OSFVQHHLZZEAPY
|
7.9 | IC50 | 2 | — | |
TUFUIJMKGKKREO
|
7.9 | IC50 | 2 | — | |
WECQTIGBRIQMEY
|
7.9 | IC50 | 2 | — | |
XGIIRMLBZISRPR
|
7.9 | IC50 | 2 | — | |
FIFBYIMXNIIZCC
|
7.9 | IC50 | 2 | — | |
GZCIDSUBIQFYQY
|
7.9 | IC50 | 3 | — | |
RVCVNRGGQGTHHO
|
7.9 | IC50 | 2 | — | |
UKNVYAQQWQVCTL
|
7.9 | IC50 | 3 | — | |
BRSPICUFRBRJOE
|
7.9 | IC50 | 2 | — | |
ARHXOWDEHGDIPR
|
7.8 | IC50 | 2 | — | |
DAVHIQXTRVNEFC
|
7.8 | IC50 | 2 | — | |
FQWJGIJPCCXPIV
|
7.8 | IC50 | 2 | — | |
NIOQRSFDCIBAAC
|
7.8 | IC50 | 2 | — | |
NJKVYAPTPKCZKS
|
7.8 | IC50 | 2 | — | |
UVIZFSBFHNHFCO
|
7.8 | IC50 | 2 | — | |
YDGQAAGNZGCGKH
|
7.8 | IC50 | 2 | — | |
ZTZSKHGZPQXQKE
|
7.8 | IC50 | 2 | — | |
GJEOIYRZBFPACS
|
7.8 | IC50 | 2 | — | |
IDIZGFUDIPHVLQ
|
7.8 | IC50 | 3 | — | |
WDGFPRBGJXWPDA
|
7.8 | IC50 | 2 | — | |
WLDZUSIGSPZSCP
|
7.8 | IC50 | 2 | — |