Target Details
| UniProt AC | P04049 |
|---|---|
| Gene Symbol | RAF1 |
| Protein Name | RAF proto-oncogene serine/threonine-protein kinase |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00130 (C1_1) PF07714 (PK_Tyr_Ser-Thr) PF02196 (RBD) |
Summary
- Multi-target molecules 2,133
- Clinical molecules 20
- Avg pChEMBL 8.1
KEGG Pathways (84)
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin signaling pathway
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Tuberculosis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (2,133)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OYYJOGYUNRBWFA
|
8.2 | IC50 | 2 | — | |
SFAHMYNGMYEECP
|
8.2 | IC50 | 2 | — | |
UODVBSONHKEZSV
|
8.2 | IC50 | 2 | — | |
XVSAYPCSLPSSHB
|
8.2 | IC50 | 2 | — | |
ZPSZTNANKKEOTN
|
8.2 | IC50 | 2 | — | |
VONWDDLXSANEKI
|
8.2 | IC50 | 2 | — | |
ATBAETXFFCOZOY
|
8.2 | IC50 | 39 | — | |
FDGNZRIUKVKUPL
|
8.2 | IC50 | 2 | — | |
NIYVAWAYJCPRAH
|
8.2 | IC50 | 2 | — | |
SLCWKPNWOMBQAA
|
8.2 | IC50 | 2 | — | |
YDYJBUHNTGURQT
|
8.2 | IC50 | 2 | — | |
JETCTCUSGZDEGL
|
8.2 | IC50 | 5 | — | |
QEZJNTJHHKUHTC
|
8.2 | IC50 | 2 | — | |
QXIYODYFHMPKBX
|
8.2 | IC50 | 3 | — | |
VRJWTLOQZAIDSH
|
8.2 | IC50 | 2 | — | |
YXCSCACYLKERDI
|
8.2 | IC50 | 2 | — | |
ZTXSUKBQPVYPPT
|
8.2 | IC50 | 2 | — | |
BVFVIFLOVGLFJR
|
8.2 | IC50 | 2 | — | |
BZWIKESOBDPPCU
|
8.2 | IC50 | 2 | — | |
CPBQPJPZJHATFS
|
8.2 | IC50 | 2 | — | |
HYRGFBOPKUXCDZ
|
8.2 | IC50 | 2 | — | |
KCAUUMYHLOPFHT
|
8.2 | IC50 | 2 | — | |
MQRBGJVORNPGNX
|
8.2 | IC50 | 3 | — | |
BZGOHTKGBPSIBL
|
8.2 | IC50 | 2 | — | |
HKFZTPMZSQRFCM
|
8.2 | IC50 | 2 | — | |
JKQCEJLFHYXPNJ
|
8.2 | IC50 | 2 | — | |
JOFFPKFVUXJPEK
|
8.2 | IC50 | 2 | — | |
SCIGXBRPGQLCGJ
|
8.2 | IC50 | 2 | — | |
AMQHWJWSTZJMPB
|
8.2 | IC50 | 2 | — | |
DEZZLWQELQORIU
|
8.2 | Kd | 5 | — | |
WSOBFSPTWJSRHQ
|
8.2 | IC50 | 2 | — | |
YZDJQTHVDDOVHR
|
8.2 | IC50 | 23 | — | |
HGXMOWBFPYFVJC
|
8.2 | IC50 | 2 | — | |
KFACCVSCGOVFGF
|
8.2 | IC50 | 2 | — | |
NOPWIOBIQPQKPS
|
8.2 | IC50 | 2 | — | |
UOKCVTIAHYTELW
|
8.2 | IC50 | 2 | — | |
WLXZGXQZOPTKEN
|
8.2 | IC50 | 3 | — | |
HPFGXLZQFXMXQP
|
8.2 | IC50 | 2 | — | |
LTVOJVSTJPPTQA
|
8.2 | IC50 | 2 | — | |
MLDQJTXFUGDVEO
|
8.2 | IC50 | 85 | Yes | |
OQHDANFEHJZHFU
|
8.2 | IC50 | 2 | — | |
QYBCFSAUZVOGTA
|
8.2 | IC50 | 2 | — | |
VDPIYNSZQSYYGQ
|
8.2 | IC50 | 5 | — | |
CAECMNOIKHANDJ
|
8.1 | IC50 | 2 | — | |
DOPSOTASKNWJRT
|
8.1 | IC50 | 2 | — | |
HMYRHTUJSGBXRF
|
8.1 | IC50 | 2 | — | |
JRYMPWHOYQXOMF
|
8.1 | IC50 | 2 | — | |
NKBBVJCVVWSTFD
|
8.1 | IC50 | 2 | — | |
YBTZROQGXQXJCA
|
8.1 | IC50 | 4 | — | |
LMXYVLFTZRPNRV
|
8.1 | IC50 | 8 | — |