Target Details
| UniProt AC | P01375 |
|---|---|
| Gene Symbol | TNF |
| Protein Name | Tumor necrosis factor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00229 (TNF) |
Summary
- Multi-target molecules 144
- Clinical molecules 5
- Avg pChEMBL 7.35
KEGG Pathways (67)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- African trypanosomiasis
- Alcoholic liver disease
- Allograft rejection
- Alzheimer disease
- Amoebiasis
- Amyotrophic lateral sclerosis
- Antifolate resistance
- Antigen processing and presentation
- Apoptosis
- Asthma
- C-type lectin receptor signaling pathway
- Chagas disease
- Coronavirus disease - COVID-19
- Cytokine-cytokine receptor interaction
- Dilated cardiomyopathy
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Graft-versus-host disease
- Hematopoietic cell lineage
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Hypertrophic cardiomyopathy
- IL-17 signaling pathway
- Inflammatory bowel disease
- Influenza A
- Insulin resistance
- Legionellosis
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Malaria
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Natural killer cell mediated cytotoxicity
- Necroptosis
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rheumatoid arthritis
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Systemic lupus erythematosus
- T cell receptor signaling pathway
- TGF-beta signaling pathway
- TNF signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type I diabetes mellitus
- Type II diabetes mellitus
- Viral protein interaction with cytokine and cytokine receptor
- Yersinia infection
- mTOR signaling pathway
Associated Diseases (6)
Active Molecules (144)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DSKICMAIGIYCOC
|
6.5 | IC50 | 2 | — | |
FSWZQANTXDTIPL
|
6.5 | IC50 | 2 | — | |
GWGMGGRSNWDNNB
|
6.5 | IC50 | 2 | — | |
HLUPPSXYWZJFNN
|
6.5 | IC50 | 2 | — | |
RGSDTVJCEBLQAT
|
6.5 | IC50 | 2 | — | |
WPDXBFCDOZUDBQ
|
6.5 | IC50 | 2 | — | |
FEGRDSCRSPKTQN
|
6.5 | IC50 | 2 | — | |
JXHFEOAFQXPYIJ
|
6.5 | IC50 | 5 | — | |
HJORMJIFDVBMOB
|
6.5 | IC50 | 6 | — | |
WWBBFDGOQJQXFK
|
6.4 | IC50 | 3 | — | |
MYTFCNPKIZVZPE
|
6.4 | IC50 | 2 | — | |
DPAAYBADQOGZSY
|
6.4 | IC50 | 2 | — | |
WEWXZCSTWDNTEE
|
6.4 | IC50 | 2 | — | |
LEKCAWLPDVDUQR
|
6.3 | IC50 | 2 | — | |
MPZRZOTXZBEGDA
|
6.3 | IC50 | 2 | — | |
NBFTZVSMVCSLPI
|
6.3 | IC50 | 2 | — | |
KFFRIQFCZUGKAV
|
6.3 | IC50 | 2 | — | |
MRLAGAZWHNUUGA
|
6.3 | IC50 | 2 | — | |
HJORMJIFDVBMOB
|
6.3 | IC50 | 6 | — | |
UPWIYKDVUPWFNE
|
6.3 | IC50 | 2 | — | |
DKEHSDCAAWFLHB
|
6.2 | IC50 | 3 | — | |
NJRSAZRJYRWJJH
|
6.2 | IC50 | 2 | — | |
SADRMVXUFCEHJG
|
6.2 | IC50 | 2 | — | |
ZWLIOLNWONUVEB
|
6.2 | IC50 | 2 | — | |
WGQPJPGVHXXIAT
|
6.2 | IC50 | 3 | — | |
ZQFNDBISEYQVRR
|
6.2 | IC50 | 2 | — | |
IDQGIAKHENYTHX
|
6.2 | IC50 | 2 | — | |
ROJFBIIHZXHUMJ
|
6.2 | IC50 | 3 | — | |
UUMJILIRWRRMQI
|
6.2 | IC50 | 2 | — | |
ZKAHFFVNALZECX
|
6.2 | IC50 | 4 | — | |
BYIUTBBPZFVDJL
|
6.2 | IC50 | 4 | — | |
GXLKSVCDXUMIAV
|
6.2 | IC50 | 3 | — | |
LGCWJBIGWQYBJP
|
6.1 | IC50 | 2 | — | |
NDEORODKVUYMFQ
|
6.1 | IC50 | 9 | — | |
VKZQLCDUHSNDRE
|
6.1 | IC50 | 2 | — | |
WIXFQAYAKRUUGT
|
6.0 | IC50 | 2 | — | |
JZFDIZGFYOAGNF
|
6.0 | IC50 | 2 | — | |
GKLAUAGSCYZMQP
|
6.0 | IC50 | 7 | Yes | |
DOBZEONUUACQKA
|
6.0 | IC50 | 2 | — | |
CIEDGRWWCWXCMK
|
6.0 | IC50 | 3 | — | |
OCSMOTCMPXTDND
|
6.0 | IC50 | 14 | Yes | |
PEPXWYFVYAYCEQ
|
6.0 | IC50 | 2 | — | |
QVFKSVSVSZNHBI
|
6.0 | IC50 | 2 | — | |
ZFXSRSREUVYGOD
|
6.0 | IC50 | 2 | — |