Target Details
| UniProt AC | P01375 |
|---|---|
| Gene Symbol | TNF |
| Protein Name | Tumor necrosis factor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00229 (TNF) |
Summary
- Multi-target molecules 144
- Clinical molecules 5
- Avg pChEMBL 7.35
KEGG Pathways (67)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- African trypanosomiasis
- Alcoholic liver disease
- Allograft rejection
- Alzheimer disease
- Amoebiasis
- Amyotrophic lateral sclerosis
- Antifolate resistance
- Antigen processing and presentation
- Apoptosis
- Asthma
- C-type lectin receptor signaling pathway
- Chagas disease
- Coronavirus disease - COVID-19
- Cytokine-cytokine receptor interaction
- Dilated cardiomyopathy
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Graft-versus-host disease
- Hematopoietic cell lineage
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Hypertrophic cardiomyopathy
- IL-17 signaling pathway
- Inflammatory bowel disease
- Influenza A
- Insulin resistance
- Legionellosis
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Malaria
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Natural killer cell mediated cytotoxicity
- Necroptosis
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rheumatoid arthritis
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Systemic lupus erythematosus
- T cell receptor signaling pathway
- TGF-beta signaling pathway
- TNF signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type I diabetes mellitus
- Type II diabetes mellitus
- Viral protein interaction with cytokine and cytokine receptor
- Yersinia infection
- mTOR signaling pathway
Associated Diseases (6)
Active Molecules (144)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ULXKKIGEUKGYFV
|
7.7 | IC50 | 2 | — | |
OIRXJBOZVQMRJB
|
7.7 | IC50 | 2 | — | |
QSXNLMNZZYKZPX
|
7.7 | IC50 | 2 | — | |
LEQMZSHFEQRYKA
|
7.7 | IC50 | 2 | — | |
NAFWTDRDFIOSGA
|
7.7 | IC50 | 2 | — | |
LAMPPZAYRXOJOM
|
7.6 | IC50 | 3 | — | |
SOKIOVRASXVGHQ
|
7.6 | IC50 | 2 | — | |
BAGPNRGIYRXXSK
|
7.6 | IC50 | 2 | — | |
OCDUSUYBHSUPGY
|
7.5 | IC50 | 2 | — | |
QBTZSDNOQVLDBB
|
7.5 | IC50 | 4 | — | |
QBTZSDNOQVLDBB
|
7.5 | IC50 | 4 | — | |
XBMCCMKXNQMPDO
|
7.5 | IC50 | 4 | — | |
PEPXWYFVYAYCEQ
|
7.5 | IC50 | 2 | — | |
UVSMNLNDYGZFPF
|
7.5 | IC50 | 7 | — | |
RSNPAKAFCAAMBH
|
7.5 | IC50 | 8 | — | |
SIHQWFDPHKCLPC
|
7.4 | IC50 | 2 | — | |
PIXPUSGFMLMDED
|
7.4 | IC50 | 2 | — | |
TUFXMLNRKGQXIH
|
7.4 | IC50 | 2 | — | |
JGVFDTLFVROGOH
|
7.4 | IC50 | 2 | — | |
JWZSSEWMVYKYKW
|
7.4 | IC50 | 3 | — | |
MYXFRXDFHFFEMK
|
7.4 | IC50 | 2 | — | |
KMNDFBRUPNNDGE
|
7.4 | IC50 | 2 | — | |
DDYGZGMTWMFEHB
|
7.3 | IC50 | 2 | — | |
IOLRUMINDIUCLJ
|
7.3 | IC50 | 8 | Yes | |
XFGDCDZADQCQNC
|
7.2 | IC50 | 2 | — | |
FQFXACCKBSPELX
|
7.2 | IC50 | 2 | — | |
NVWKNQGHVMMAJW
|
7.2 | IC50 | 2 | — | |
CLAXNEXHGNUKBG
|
7.2 | IC50 | 2 | — | |
ZWHJGDGKNAKKAK
|
7.1 | IC50 | 2 | — | |
YLYBCGXZHNGCHE
|
7.1 | IC50 | 2 | — | |
ROGXRBIZXSSLJN
|
7.0 | IC50 | 2 | — | |
CSGOXEMKTHBXKE
|
7.0 | IC50 | 3 | — | |
RQVALWJXDPCRBH
|
6.9 | IC50 | 2 | — | |
PFNLTXPEWXUGPM
|
6.8 | IC50 | 3 | — | |
FOCBXVWTIKRGEO
|
6.8 | IC50 | 2 | — | |
SGJMISOKPTWCGI
|
6.8 | IC50 | 2 | — | |
SHXAYINEIAIQRK
|
6.7 | IC50 | 2 | — | |
DLVHYSMNJZZBJZ
|
6.7 | IC50 | 2 | — | |
WEZRHPWWPXDLTL
|
6.7 | IC50 | 3 | — | |
MLIXXTQKHWNRCZ
|
6.7 | IC50 | 2 | — | |
GOTYRUGSSMKFNF
|
6.7 | IC50 | 6 | — | |
HSJGHXJDAJQGPF
|
6.6 | IC50 | 2 | — | |
FUOSKBKPXMUPKQ
|
6.6 | IC50 | 2 | — | |
RBKGJKUWWDNBNT
|
6.6 | IC50 | 2 | — | |
OIGNJSKKLXVSLS
|
6.6 | IC50 | 7 | — | |
KNCYWVRUUBOHGE
|
6.6 | IC50 | 7 | Yes | |
USNHXPAJBZXQCY
|
6.6 | IC50 | 2 | — | |
HXNUFFCHRIWTRZ
|
6.5 | IC50 | 5 | — | |
LTRCCXKUSQMIAV
|
6.5 | IC50 | 2 | — | |
CTKOXUCFTIUYMF
|
6.5 | IC50 | 2 | — |