Target Details
| UniProt AC | P01375 |
|---|---|
| Gene Symbol | TNF |
| Protein Name | Tumor necrosis factor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00229 (TNF) |
Summary
- Multi-target molecules 144
- Clinical molecules 5
- Avg pChEMBL 7.35
KEGG Pathways (67)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- African trypanosomiasis
- Alcoholic liver disease
- Allograft rejection
- Alzheimer disease
- Amoebiasis
- Amyotrophic lateral sclerosis
- Antifolate resistance
- Antigen processing and presentation
- Apoptosis
- Asthma
- C-type lectin receptor signaling pathway
- Chagas disease
- Coronavirus disease - COVID-19
- Cytokine-cytokine receptor interaction
- Dilated cardiomyopathy
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Graft-versus-host disease
- Hematopoietic cell lineage
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Hypertrophic cardiomyopathy
- IL-17 signaling pathway
- Inflammatory bowel disease
- Influenza A
- Insulin resistance
- Legionellosis
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Malaria
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Natural killer cell mediated cytotoxicity
- Necroptosis
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rheumatoid arthritis
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Systemic lupus erythematosus
- T cell receptor signaling pathway
- TGF-beta signaling pathway
- TNF signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type I diabetes mellitus
- Type II diabetes mellitus
- Viral protein interaction with cytokine and cytokine receptor
- Yersinia infection
- mTOR signaling pathway
Associated Diseases (6)
Active Molecules (144)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CTKRVYLHFHYHOK
|
9.5 | IC50 | 2 | — | |
IEYGNATYSGSBRX
|
9.5 | IC50 | 2 | — | |
HYQJMZNWNFLLRO
|
9.4 | IC50 | 2 | — | |
VBDPBRNLIHHGNF
|
9.4 | IC50 | 2 | — | |
XUUYDWPUWOPVDD
|
9.4 | IC50 | 2 | — | |
RPIXUTROJMVGDZ
|
9.3 | Ki | 2 | — | |
IXZOHGPZAQLIBH
|
9.2 | IC50 | 8 | — | |
RWLRTFPNLBUMPG
|
9.2 | IC50 | 2 | — | |
ZRGJKRMJNFVOLW
|
9.1 | IC50 | 2 | — | |
DFTGKUJJDBYDBZ
|
9.0 | IC50 | 2 | — | |
MYNFJASRUQCJTA
|
9.0 | IC50 | 2 | — | |
QEHLDAILVPJKJD
|
9.0 | IC50 | 2 | — | |
RUKDKMBIZSFODD
|
9.0 | IC50 | 2 | — | |
VLSIAPYZDCCBPU
|
9.0 | IC50 | 4 | — | |
WLPGFXATLLKQGT
|
9.0 | IC50 | 2 | — | |
ZPBLUEXWDMMUHO
|
9.0 | IC50 | 2 | — | |
IXZOHGPZAQLIBH
|
8.7 | IC50 | 6 | — | |
CTKRVYLHFHYHOK
|
8.7 | IC50 | 2 | — | |
JMKXHWHMULJLQG
|
8.7 | IC50 | 4 | — | |
JUOMAZJAWFVNCD
|
8.7 | IC50 | 2 | — | |
LXSZIQSHGAAWFX
|
8.7 | IC50 | 2 | — | |
NSKDLLYTWJVRPJ
|
8.7 | IC50 | 2 | — | |
PYZDPPRYPHIHCL
|
8.7 | IC50 | 2 | — | |
MUQKVPSLHRVESB
|
8.6 | IC50 | 4 | — | |
AUWCRYUPRHMNCJ
|
8.5 | IC50 | 2 | — | |
JZNXLPPJRFFECJ
|
8.4 | Kd | 2 | — | |
BOWZLOCTDYTWKK
|
8.4 | IC50 | 2 | — | |
HMHMNSOEZLANDL
|
8.4 | IC50 | 2 | — | |
CZVSIRAXWOPYTM
|
8.3 | IC50 | 2 | — | |
NMCBQDCTQPGXHQ
|
8.2 | IC50 | 4 | — | |
PUVOZFSDIYNDGR
|
8.2 | IC50 | 2 | — | |
QMGJUCFLYMBHRX
|
8.2 | IC50 | 4 | — | |
CIMXKGKYBNXAKQ
|
8.1 | IC50 | 2 | — | |
FNQYKWPUVQVOFV
|
8.1 | IC50 | 2 | — | |
UFKSSXQQJYIWAM
|
8.1 | IC50 | 2 | — | |
SISZTYKGUNKWOD
|
8.1 | IC50 | 2 | — | |
JUZPJZSDHMNYSS
|
8.1 | IC50 | 2 | — | |
QQWDOWSOVDBKKC
|
8.1 | IC50 | 2 | — | |
ATUIUMZYBUFUGD
|
8.0 | IC50 | 2 | — | |
IXZOHGPZAQLIBH
|
8.0 | IC50 | 6 | — | |
LTVIJEFEZVFIST
|
8.0 | IC50 | 14 | Yes | |
HKSWAIDHHZHZTD
|
8.0 | IC50 | 6 | — | |
PYTXPVHJIDYQEO
|
8.0 | IC50 | 2 | — | |
OMXHGVKXXBJXJC
|
7.9 | IC50 | 2 | — | |
UGPFGFFOQUXAPN
|
7.9 | IC50 | 2 | — | |
DAHGZUIVGPCBIV
|
7.8 | IC50 | 2 | — | |
VCNXQNDWYNKLJX
|
7.8 | IC50 | 2 | — | |
XGXBMGWSSWJKMV
|
7.8 | IC50 | 2 | — | |
MNBFWFCWGJRPOH
|
7.7 | IC50 | 2 | — | |
DJUHKBSBFFEXJI
|
7.7 | IC50 | 2 | — |