Target Details
| UniProt AC | P01137 |
|---|---|
| Gene Symbol | TGFB1 |
| Protein Name | Transforming growth factor beta-1 proprotein |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00019 (TGF_beta) PF00688 (TGFb_propeptide) |
Summary
- Multi-target molecules 8
- Clinical molecules 0
- Avg pChEMBL 7.34
KEGG Pathways (36)
- AGE-RAGE signaling pathway in diabetic complications
- Amoebiasis
- Cell cycle
- Cellular senescence
- Chagas disease
- Chronic myeloid leukemia
- Colorectal cancer
- Cytokine-cytokine receptor interaction
- Diabetic cardiomyopathy
- Dilated cardiomyopathy
- Efferocytosis
- FoxO signaling pathway
- Gastric cancer
- Hepatitis B
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human T-cell leukemia virus 1 infection
- Hypertrophic cardiomyopathy
- Inflammatory bowel disease
- Integrin signaling
- Intestinal immune network for IgA production
- Leishmaniasis
- MAPK signaling pathway
- Malaria
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Pathways in cancer
- Proteoglycans in cancer
- Relaxin signaling pathway
- Renal cell carcinoma
- Rheumatoid arthritis
- TGF-beta signaling pathway
- Th17 cell differentiation
- Toxoplasmosis
- Tuberculosis
Associated Diseases (5)
Active Molecules (8)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QPFVXQGTWSDAJK
|
8.0 | IC50 | 3 | — | |
FJCDSQATIJKQKA
|
7.9 | IC50 | 5 | — | |
VYTQMUCONGRNBX
|
7.7 | IC50 | 3 | — | |
BVWNOAMYVMKTGC
|
7.5 | IC50 | 3 | — | |
AQPVZDUZQVWOEP
|
7.2 | IC50 | 3 | — | |
YWKTUNHCMPHUCG
|
7.1 | IC50 | 3 | — | |
RRSMQTBPLPCBAN
|
7.1 | IC50 | 3 | — | |
SAGZIBJAQGBRQA
|
6.3 | IC50 | 2 | — |