Target Details
| UniProt AC | P01116 |
|---|---|
| Gene Symbol | KRAS |
| Protein Name | GTPase KRas |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00071 (Ras) |
Summary
- Multi-target molecules 1,811
- Clinical molecules 3
- Avg pChEMBL 7.14
KEGG Pathways (84)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Alcoholism
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Mitophagy - animal
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thermogenesis
- Thyroid cancer
- Thyroid hormone signaling pathway
- VEGF signaling pathway
- Viral carcinogenesis
- mTOR signaling pathway
Associated Diseases (30)
- Acute myeloid leukemia
- Angiosarcoma
- Arteriovenous malformations of the brain
- Atypical chronic myeloid leukemia
- Autoimmune lymphoproliferative syndromes
- Bladder cancer
- Cardiofaciocutaneous syndrome
- Cervical cancer
- Cholangiocarcinoma
- Chronic myelomonocytic leukemia
- Colorectal cancer
- Endometrial cancer
- Erdheim-Chester disease
- Gallbladder cancer
- Gastric cancer
- Hepatic angiosarcoma
- Juvenile myelomonocytic leukemia
- Kaposi sarcoma
- Medullary thyroid cancer
- Multiple myeloma
- Myelodysplastic/myeloproliferative neoplasms
- Non-small cell lung cancer
- Noonan syndrome
- Noonan syndrome and related disorders
- Oral cancer
- Ovarian cancer
- Pancreatic cancer
- Schimmelpenning-Feuerstein-Mims syndrome
- Squamous cell carcinoma
- Thyroid cancer
Active Molecules (1,811)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZWDJXGMYAKFYGQ
|
8.5 | IC50 | 2 | — | |
BGRKBJVMTURZBQ
|
8.5 | IC50 | 2 | — | |
CXWDWXDMNLGZBW
|
8.5 | IC50 | 2 | — | |
FGZLNWASTZPNLC
|
8.5 | IC50 | 2 | — | |
FTWZLBLTONBYHH
|
8.5 | IC50 | 2 | — | |
HRTWETMBLURISK
|
8.5 | IC50 | 2 | — | |
JFUYUTORRPOVER
|
8.5 | IC50 | 2 | — | |
NPFWDQYMNIFZAH
|
8.5 | IC50 | 2 | — | |
CDEMFJBHKSTJBV
|
8.5 | IC50 | 2 | — | |
KYWMFGRLQZUNRD
|
8.5 | IC50 | 2 | — | |
NXUXDOAOHBPRPQ
|
8.5 | IC50 | 2 | — | |
UHFVWDBPFPIPSX
|
8.5 | IC50 | 2 | — | |
CBGMFCKSQARWES
|
8.4 | IC50 | 2 | — | |
CTWHCQOSGTUDTI
|
8.4 | IC50 | 2 | — | |
JESLNXDJBCYBBK
|
8.4 | IC50 | 2 | — | |
LECCRWPQHHHXEG
|
8.4 | IC50 | 2 | — | |
VEXRXMWZGLSCPC
|
8.4 | IC50 | 2 | — | |
VQQQDOFXWFHFFS
|
8.4 | IC50 | 2 | — | |
GFONDRQIDTUGNO
|
8.4 | IC50 | 2 | — | |
GHGDXGIBYAFMJZ
|
8.4 | IC50 | 2 | — | |
UVNQICXVXBBWBT
|
8.4 | IC50 | 2 | — | |
ACNIGGXNBAGWAL
|
8.4 | IC50 | 2 | — | |
AUBYCSKNJWSVFD
|
8.4 | IC50 | 2 | — | |
BPUGJDAQXBLEES
|
8.4 | IC50 | 2 | — | |
CCZMGVUPQVLFQE
|
8.4 | IC50 | 2 | — | |
CSMXSTFEQJRFJB
|
8.4 | IC50 | 2 | — | |
DRKFKMCMFBMNPX
|
8.4 | IC50 | 2 | — | |
FHUPYSDNLIRUTO
|
8.4 | IC50 | 2 | — | |
FNCBEVUDTZYUJD
|
8.4 | IC50 | 2 | — | |
FOMRDGOGXWHHPF
|
8.4 | IC50 | 2 | — | |
FRJGHWCMERVQNX
|
8.4 | IC50 | 2 | — | |
GSIYKERYWYJMIC
|
8.4 | IC50 | 2 | — | |
HNVFYUAXKGDPJY
|
8.4 | IC50 | 2 | — | |
HOWMCJREBXFBJM
|
8.4 | IC50 | 2 | — | |
IBUDGJIEMFVDDJ
|
8.4 | IC50 | 2 | — | |
JMJBAHZUQNQSGI
|
8.4 | IC50 | 2 | — | |
JTAUMIJPRRULAD
|
8.4 | IC50 | 3 | — | |
KJXDYWKYMITBKG
|
8.4 | IC50 | 2 | — | |
KPCHQBHOEVTDBB
|
8.4 | IC50 | 2 | — | |
KWPMDODRFACSFM
|
8.4 | IC50 | 2 | — | |
PGYXLQHSQVAQAG
|
8.4 | IC50 | 2 | — | |
SEJYEYDGHUWBEN
|
8.4 | IC50 | 2 | — | |
SFOBNFTWEMNFEH
|
8.4 | IC50 | 2 | — | |
SQRRKLYAIUOFDH
|
8.4 | IC50 | 2 | — | |
UFEBIPUVEJHURX
|
8.4 | IC50 | 2 | — | |
UOWZLEGGMBTOCO
|
8.4 | IC50 | 2 | — | |
UPGJJZISRBTWIN
|
8.4 | IC50 | 2 | — | |
UUYULGJWPNXBGF
|
8.4 | IC50 | 2 | — | |
VGBCDEBUDZMQQH
|
8.4 | IC50 | 2 | — | |
VRYFRNUPBQYDAQ
|
8.4 | IC50 | 2 | — |