Target Details
| UniProt AC | P01116 |
|---|---|
| Gene Symbol | KRAS |
| Protein Name | GTPase KRas |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00071 (Ras) |
Summary
- Multi-target molecules 1,811
- Clinical molecules 3
- Avg pChEMBL 7.14
KEGG Pathways (84)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Alcoholism
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Mitophagy - animal
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thermogenesis
- Thyroid cancer
- Thyroid hormone signaling pathway
- VEGF signaling pathway
- Viral carcinogenesis
- mTOR signaling pathway
Associated Diseases (30)
- Acute myeloid leukemia
- Angiosarcoma
- Arteriovenous malformations of the brain
- Atypical chronic myeloid leukemia
- Autoimmune lymphoproliferative syndromes
- Bladder cancer
- Cardiofaciocutaneous syndrome
- Cervical cancer
- Cholangiocarcinoma
- Chronic myelomonocytic leukemia
- Colorectal cancer
- Endometrial cancer
- Erdheim-Chester disease
- Gallbladder cancer
- Gastric cancer
- Hepatic angiosarcoma
- Juvenile myelomonocytic leukemia
- Kaposi sarcoma
- Medullary thyroid cancer
- Multiple myeloma
- Myelodysplastic/myeloproliferative neoplasms
- Non-small cell lung cancer
- Noonan syndrome
- Noonan syndrome and related disorders
- Oral cancer
- Ovarian cancer
- Pancreatic cancer
- Schimmelpenning-Feuerstein-Mims syndrome
- Squamous cell carcinoma
- Thyroid cancer
Active Molecules (1,811)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MPCCWLKZACKKGV
|
9.9 | IC50 | 2 | — | |
XLWBILUNGOIIFR
|
9.7 | Kd | 3 | — | |
JAFOQUTZMCAMCY
|
9.4 | IC50 | 3 | — | |
SCLLZBIBSFTLIN
|
9.4 | IC50 | 3 | — | |
STJIVFPUHQRHHP
|
9.4 | IC50 | 2 | — | |
JQADGZCFGZVFDH
|
9.2 | IC50 | 2 | — | |
WQIJXHGCGUZFIC
|
9.2 | IC50 | 2 | — | |
DDTMLXBXDLXCQJ
|
9.0 | IC50 | 2 | — | |
GBCFKGCLSSSUMK
|
9.0 | IC50 | 2 | — | |
GBCFKGCLSSSUMK
|
9.0 | IC50 | 2 | — | |
HEYHLAZVGYNRDI
|
9.0 | IC50 | 2 | — | |
JWVRZIMDGQYNFL
|
9.0 | IC50 | 2 | — | |
KWKCHNKUWLFWCU
|
9.0 | IC50 | 2 | — | |
LGMZCQHPANSOFF
|
9.0 | IC50 | 2 | — | |
LPUKIUZDTNDJCL
|
9.0 | IC50 | 2 | — | |
MSUMHTZLPIWNMH
|
9.0 | IC50 | 2 | — | |
NQFMXXRDHAOYNG
|
9.0 | IC50 | 2 | — | |
OHWWJWNBZRICPR
|
9.0 | IC50 | 2 | — | |
PGQDMPGFHCCYAL
|
9.0 | IC50 | 2 | — | |
QXMGEIYPWDDQCX
|
9.0 | IC50 | 2 | — | |
RLCWCKHZJRMBFS
|
9.0 | IC50 | 2 | — | |
RXELUWXNOJHEEJ
|
9.0 | IC50 | 2 | — | |
SGDPSOKNGBLBJZ
|
9.0 | IC50 | 2 | — | |
SGDPSOKNGBLBJZ
|
9.0 | IC50 | 2 | — | |
VHCTXEMYIMMRJS
|
9.0 | IC50 | 2 | — | |
VHCTXEMYIMMRJS
|
9.0 | IC50 | 2 | — | |
VREMEYIGVQDHHO
|
9.0 | IC50 | 2 | — | |
XNJHRLGOJPVESX
|
9.0 | IC50 | 2 | — | |
XZCGBNGXGZJFCN
|
9.0 | IC50 | 2 | — | |
YPXMSOODCRETLP
|
9.0 | IC50 | 2 | — | |
ZHZYGNMJAXEYEV
|
9.0 | IC50 | 2 | — | |
ZRRQHTTZRDQTGY
|
9.0 | IC50 | 2 | — | |
KPUMNLZNWCMNEJ
|
8.8 | IC50 | 2 | — | |
NUFDCNVCOXIFGR
|
8.8 | IC50 | 2 | — | |
XHGWQPVXYTVOGF
|
8.8 | IC50 | 2 | — | |
ANIPNHZWVMYJLY
|
8.7 | IC50 | 2 | — | |
BEUZFLDAEOFGNM
|
8.7 | IC50 | 2 | — | |
BIEZLUTYPITYLL
|
8.7 | IC50 | 2 | — | |
BKDXPAAVRWPDPX
|
8.7 | IC50 | 2 | — | |
BUIOJFPVYMAXFD
|
8.7 | IC50 | 2 | — | |
CMCXWVBCHOAIEX
|
8.7 | IC50 | 2 | — | |
CNZVROLTTYQZCO
|
8.7 | IC50 | 2 | — | |
CPDOGCGQQAAZIW
|
8.7 | IC50 | 2 | — | |
CPDOGCGQQAAZIW
|
8.7 | IC50 | 2 | — | |
CPEJDIYHZXLMJL
|
8.7 | IC50 | 2 | — | |
DCFCUOGLXHAKCW
|
8.7 | IC50 | 2 | — | |
DFXYJVTZPXGTKU
|
8.7 | IC50 | 2 | — | |
FHNTVNJVRBRJNA
|
8.7 | IC50 | 2 | — | |
FHTWBXIIMXEFEM
|
8.7 | IC50 | 2 | — | |
GPVOHUGMEQFZAX
|
8.7 | IC50 | 2 | — |