Target Details
| UniProt AC | P01112 |
|---|---|
| Gene Symbol | HRAS |
| Protein Name | GTPase HRas |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00071 (Ras) |
Summary
- Multi-target molecules 14
- Clinical molecules 12
- Avg pChEMBL 7.76
KEGG Pathways (85)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Insulin signaling pathway
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Mitophagy - animal
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thermogenesis
- Thyroid cancer
- Thyroid hormone signaling pathway
- VEGF signaling pathway
- Viral carcinogenesis
- mTOR signaling pathway
Associated Diseases (14)
- Angiosarcoma
- Bladder cancer
- Cervical cancer
- Congenital melanocytic nevus syndrome
- Costello syndrome
- Epidermal nevus
- Giant cell tumor of bone
- Medullary thyroid cancer
- Merkel cell carcinoma
- Noonan syndrome and related disorders
- Penile cancer
- Schimmelpenning-Feuerstein-Mims syndrome
- Squamous cell carcinoma
- Thyroid cancer
Active Molecules (14)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OLCWFLWEHWLBTO
|
8.9 | IC50 | 4 | Yes | |
JNUGFGAVPBYSHF
|
8.8 | Ki | 5 | Yes | |
QIVUVRPLLRMTDC
|
8.7 | IC50 | 4 | Yes | |
BYBHPNRNQQCSBT
|
7.8 | IC50 | 5 | Yes | |
RLHGRWTYHJYFHW
|
7.8 | IC50 | 5 | Yes | |
SWYZYRFTUDNTMP
|
7.8 | IC50 | 5 | Yes | |
VTUJRELIRZNVDP
|
7.8 | IC50 | 5 | Yes | |
ZTNNTIMDSDUVON
|
7.8 | IC50 | 5 | Yes | |
HTKQZECDKPTYRG
|
7.7 | IC50 | 5 | Yes | |
HYSLEZHDLSYQLQ
|
7.7 | IC50 | 5 | Yes | |
MJHHFDJNRRCUOB
|
7.3 | Kd | 2 | — | |
DHMTURDWPRKSOA
|
7.2 | IC50 | 4 | Yes | |
UPBAOYRENQEPJO
|
6.7 | IC50 | 5 | Yes | |
WEGLOYDTDILXDA
|
6.5 | IC50 | 22 | — |