Target Details
| UniProt AC | P01111 |
|---|---|
| Gene Symbol | NRAS |
| Protein Name | GTPase NRas |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00071 (Ras) |
Summary
- Multi-target molecules 923
- Clinical molecules 1
- Avg pChEMBL 6.67
KEGG Pathways (81)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Alcoholism
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Mitophagy - animal
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Serotonergic synapse
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thermogenesis
- Thyroid cancer
- Thyroid hormone signaling pathway
- VEGF signaling pathway
- Viral carcinogenesis
- mTOR signaling pathway
Associated Diseases (20)
- Acute myeloid leukemia
- Adrenal carcinoma
- Angiosarcoma
- Atypical chronic myeloid leukemia
- Autoimmune lymphoproliferative syndromes
- Chronic myelomonocytic leukemia
- Congenital melanocytic nevus syndrome
- Epidermal nevus
- Erdheim-Chester disease
- Gastric cancer
- Juvenile myelomonocytic leukemia
- Melanoma
- Multiple myeloma
- Myelodysplastic/myeloproliferative neoplasms
- Neurocutaneous melanosis
- Noonan syndrome
- Noonan syndrome and related disorders
- Oral cancer
- Schimmelpenning-Feuerstein-Mims syndrome
- Thyroid cancer
Active Molecules (923)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FUYCNSZSLMHCOD
|
7.3 | IC50 | 2 | — | |
FVIWVSOLYXJXEH
|
7.3 | IC50 | 2 | — | |
FVKLRZDWJPCQDO
|
7.3 | IC50 | 2 | — | |
FWTPKISPLZOJHN
|
7.3 | IC50 | 2 | — | |
GDUZEXIEWAVBTA
|
7.3 | IC50 | 2 | — | |
GDUZEXIEWAVBTA
|
7.3 | IC50 | 2 | — | |
GFNDELQKEXXURO
|
7.3 | IC50 | 2 | — | |
GFQRRKVUHLOCPB
|
7.3 | IC50 | 2 | — | |
GIIGMUBPCWXFQB
|
7.3 | IC50 | 2 | — | |
GKLKEBPDKMZLFV
|
7.3 | IC50 | 2 | — | |
GKXRKCHEHGLYMA
|
7.3 | IC50 | 2 | — | |
GKXRKCHEHGLYMA
|
7.3 | IC50 | 2 | — | |
GNSMRWXAUFIMEW
|
7.3 | IC50 | 2 | — | |
GOQNXYOULQCGRC
|
7.3 | IC50 | 2 | — | |
GOVKLQHDTFLFSF
|
7.3 | IC50 | 2 | — | |
GVKSSYHJUDFLIT
|
7.3 | IC50 | 2 | — | |
GWRKWZIWOUBESZ
|
7.3 | IC50 | 2 | — | |
GYGLHAGERKBZDH
|
7.3 | IC50 | 2 | — | |
HACVIVWYYHQMBM
|
7.3 | IC50 | 2 | — | |
HBQCJHCCIPVNSV
|
7.3 | IC50 | 2 | — | |
HBULXANBGZGACC
|
7.3 | IC50 | 2 | — | |
HCEWPVHVZSCWBQ
|
7.3 | IC50 | 2 | — | |
HCPDMWSJNIUDJF
|
7.3 | IC50 | 2 | — | |
HFNNUJNKAWHOAL
|
7.3 | IC50 | 2 | — | |
HHRQGUIULJRDMP
|
7.3 | IC50 | 2 | — | |
HJHBPFLDRXZUQI
|
7.3 | IC50 | 2 | — | |
HLJWFJZJLZLMJV
|
7.3 | IC50 | 2 | — | |
HPLVVGKBQMIPCK
|
7.3 | IC50 | 2 | — | |
HQUHXXXTDVJWQB
|
7.3 | IC50 | 2 | — | |
HQUHXXXTDVJWQB
|
7.3 | IC50 | 2 | — | |
HTZVIKZWMWMAPD
|
7.3 | IC50 | 2 | — | |
HVHSIQUWHJPOAP
|
7.3 | IC50 | 2 | — | |
HXJIJBKXPUCJPG
|
7.3 | IC50 | 2 | — | |
HXZDWYMWSGORPJ
|
7.3 | IC50 | 2 | — | |
ICFBAKIBGXOTCL
|
7.3 | IC50 | 2 | — | |
IICRPLUPLHCJKS
|
7.3 | IC50 | 2 | — | |
IODDBYJQNLRXFB
|
7.3 | IC50 | 2 | — | |
IOLVPHKCPIQVDO
|
7.3 | IC50 | 2 | — | |
IPLBWQKESQXFRQ
|
7.3 | IC50 | 2 | — | |
IQSGTJKBLGDEDM
|
7.3 | IC50 | 2 | — | |
ISLICLDMKOZGAE
|
7.3 | IC50 | 2 | — | |
ISLICLDMKOZGAE
|
7.3 | IC50 | 2 | — | |
ISNRJNXRDYBOEY
|
7.3 | IC50 | 2 | — | |
IUKNWVGAPTWPBU
|
7.3 | IC50 | 2 | — | |
IUKNWVGAPTWPBU
|
7.3 | IC50 | 2 | — | |
IUKNWVGAPTWPBU
|
7.3 | IC50 | 2 | — | |
IUTJMCXOMIQZNH
|
7.3 | IC50 | 2 | — | |
IVMSNWIMGHYAEI
|
7.3 | IC50 | 2 | — | |
IVMSNWIMGHYAEI
|
7.3 | IC50 | 2 | — | |
IVZOHOFFDWRRAR
|
7.3 | IC50 | 2 | — |