Target Details
| UniProt AC | P01100 |
|---|---|
| Gene Symbol | FOS |
| Protein Name | Protein c-Fos |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00170 (bZIP_1) |
Summary
- Multi-target molecules 25
- Clinical molecules 0
- Avg pChEMBL 6.54
KEGG Pathways (45)
- Amphetamine addiction
- Apoptosis
- B cell receptor signaling pathway
- Breast cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Colorectal cancer
- Coronavirus disease - COVID-19
- Dopaminergic synapse
- Endocrine resistance
- Estrogen signaling pathway
- Fluid shear stress and atherosclerosis
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Parathyroid hormone synthesis, secretion and action
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pertussis
- Prolactin signaling pathway
- Relaxin signaling pathway
- Rheumatoid arthritis
- Salmonella infection
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (25)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VFLDPWHFBUODDF
|
8.2 | IC50 | 25 | — | |
KBCXTBOXZPZBNM
|
7.7 | IC50 | 5 | — | |
BMEOHHZTHGXSLS
|
7.0 | IC50 | 5 | — | |
NKVHDZTUPQKDRT
|
7.0 | IC50 | 5 | — | |
AHRPMNUHBXZQDF
|
6.7 | IC50 | 5 | — | |
DWADBTCPCYEZHD
|
6.7 | IC50 | 5 | — | |
NVROPPGYYYTZRD
|
6.7 | IC50 | 5 | — | |
PTHWPWGFLGQPPP
|
6.7 | IC50 | 5 | — | |
WKVHCLGIAQDALT
|
6.7 | IC50 | 5 | — | |
ADFOLUXMYYCTRR
|
6.7 | IC50 | 2 | — | |
BQSQYQQCGHOGDS
|
6.5 | IC50 | 5 | — | |
CRDXILZNMTVNLW
|
6.5 | IC50 | 5 | — | |
CWMSEWLBVPSYON
|
6.5 | IC50 | 5 | — | |
DWVXJMXXTULGDP
|
6.5 | IC50 | 5 | — | |
HJAKTQAHKIJTKU
|
6.5 | IC50 | 5 | — | |
XYBIZGOXEPWEFZ
|
6.4 | IC50 | 5 | — | |
BFUXXUCYXDKBGL
|
6.2 | IC50 | 5 | — | |
DSYPQICAGKUAFT
|
6.2 | IC50 | 5 | — | |
XOHKOCNFVBVEEY
|
6.2 | IC50 | 5 | — | |
QRVJINBBPOWTHS
|
6.0 | IC50 | 5 | — | |
JWIIKHRJOUQCQG
|
6.0 | IC50 | 5 | — | |
KBGATAWDHCZFQR
|
6.0 | IC50 | 5 | — | |
MMSKFTCJMPJSON
|
6.0 | IC50 | 5 | — | |
YHCPTBQDJKEVNL
|
6.0 | IC50 | 5 | — | |
YZVLYVMNCAIILW
|
6.0 | IC50 | 5 | — |