Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
GDRLJBDXWDATLA
|
8.4 | IC50 | 13 | — | |
HZYHQHCKBTWZMB
|
8.4 | IC50 | 3 | — | |
ISEHGRGNSOYPTL
|
8.4 | IC50 | 3 | Yes | |
LAPPKGYTRPDHPM
|
8.4 | IC50 | 2 | — | |
LRCDTAPSEBUEOO
|
8.4 | IC50 | 2 | — | |
LTEDLCRFOMFLOT
|
8.4 | IC50 | 3 | — | |
NFYCOJYOZFPVRD
|
8.4 | IC50 | 2 | — | |
RZLHXVSQWOPUOD
|
8.4 | IC50 | 2 | — | |
SFZSLQNVKFDVLY
|
8.4 | IC50 | 2 | Yes | |
UEKLAZGZLXRYAO
|
8.4 | IC50 | 2 | — | |
UNXBSODPRVRIBE
|
8.4 | IC50 | 2 | — | |
VGQHMTSLJFXLBO
|
8.4 | IC50 | 2 | — | |
XLWAURRDDANSTB
|
8.4 | IC50 | 2 | — | |
XXKKLMVAVKRRTQ
|
8.4 | Ki | 2 | — | |
XXQCAOCIBBLKTR
|
8.4 | IC50 | 2 | — | |
YMDWARQKAFASNA
|
8.4 | IC50 | 2 | — | |
YRXBBYUECWYNNN
|
8.4 | IC50 | 2 | — | |
ZDHUOHXJOTTYGN
|
8.4 | IC50 | 2 | — | |
BGPAHUNSGVWHIG
|
8.4 | IC50 | 2 | — | |
KFBKCZIAECRELC
|
8.4 | IC50 | 2 | Yes | |
LYKFUIDYYBNHOA
|
8.4 | IC50 | 2 | — | |
NLSNSCBPWXRRPL
|
8.4 | IC50 | 3 | — | |
OSBNTMYQLUCHOK
|
8.4 | IC50 | 2 | — | |
AMKFBXVTNZFKFF
|
8.4 | IC50 | 4 | — | |
LJRGBEPLXWZRBM
|
8.4 | IC50 | 3 | — | |
UMBIRSZUCJNBHB
|
8.4 | IC50 | 18 | — | |
YSFGCARYACLFDS
|
8.4 | IC50 | 7 | Yes | |
YYQSQLGNBWMYFW
|
8.4 | IC50 | 2 | — | |
IFGRZKHRJZWZKC
|
8.4 | IC50 | 2 | — | |
DWKWPKBAUKFSKF
|
8.4 | IC50 | 2 | Yes | |
FZXFZHFLUJFRGT
|
8.4 | IC50 | 2 | — | |
OIPWVAYMLKMQOR
|
8.4 | IC50 | 2 | — | |
PJADTLKXGYODKV
|
8.4 | IC50 | 2 | — | |
RSAVYUKMYLHWGE
|
8.4 | IC50 | 2 | Yes | |
CBRVEUABHHKTIL
|
8.3 | IC50 | 2 | Yes | |
DJAMFWBXWBHEQD
|
8.3 | IC50 | 2 | — | |
ISBCSIOQNRNSBX
|
8.3 | IC50 | 2 | — | |
NECNOKMWRWJOGB
|
8.3 | IC50 | 3 | — | |
BFRZHSWXTMOYRY
|
8.3 | IC50 | 2 | — | |
FQGVUAQWOXXERW
|
8.3 | IC50 | 3 | Yes | |
GQTMXLIHJOTTCN
|
8.3 | IC50 | 2 | — | |
HRLHWOFWUMHHIP
|
8.3 | IC50 | 2 | Yes | |
JFCHPYHJJFGZSB
|
8.3 | IC50 | 3 | Yes | |
JZSLVCXMHPNGNA
|
8.3 | IC50 | 5 | — | |
MWBUVVRWOPAWQU
|
8.3 | IC50 | 2 | — | |
NYCRPERPKUAEHF
|
8.3 | IC50 | 3 | — | |
OETCDAITXCDXIB
|
8.3 | IC50 | 3 | Yes | |
WFLJBHIMLGVBCP
|
8.3 | IC50 | 2 | — | |
XFDYLGGJRSOHKI
|
8.3 | IC50 | 13 | Yes | |
ZFSYJCQFOKJSFE
|
8.3 | IC50 | 2 | — |