Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SHKHWNUDFOMKAK
|
8.5 | IC50 | 2 | — | |
TXDNKWWXILESGX
|
8.5 | IC50 | 2 | — | |
UIKREWNIYFBAFO
|
8.5 | IC50 | 2 | — | |
VZMZAYAKDHWCNK
|
8.5 | IC50 | 2 | — | |
WJHKUMPTDFBBGR
|
8.5 | IC50 | 2 | — | |
WUQQSPODIZWQJL
|
8.5 | IC50 | 2 | — | |
WWVSQNVNUAFENV
|
8.5 | IC50 | 2 | Yes | |
YJEHFTZFENYBBO
|
8.5 | IC50 | 2 | Yes | |
GCDSDVNITVBCDW
|
8.5 | IC50 | 17 | — | |
GSDQZJWVOBCWHP
|
8.5 | IC50 | 2 | — | |
RQYVKBOWLRVISJ
|
8.5 | IC50 | 14 | Yes | |
ZUKLWMMHDKSDMF
|
8.5 | IC50 | 2 | — | |
XFPJOZFYIPJGKP
|
8.5 | IC50 | 2 | — | |
ZOLXNVOLRGVYNI
|
8.5 | IC50 | 2 | — | |
GKHQYWVFWRHIKE
|
8.5 | IC50 | 2 | — | |
IMLBZWHQWRDARS
|
8.5 | IC50 | 4 | — | |
OONFNUWBHFSNBT
|
8.5 | Kd | 11 | — | |
OQOUVSHMBYJEIH
|
8.5 | IC50 | 2 | — | |
GNBZJTFEESJZBO
|
8.5 | IC50 | 2 | — | |
KKNXUMNCAJWDKL
|
8.5 | IC50 | 2 | — | |
PRTPANUTPYMUDM
|
8.5 | IC50 | 3 | — | |
CADRLZXVKIQPSG
|
8.5 | IC50 | 13 | Yes | |
OYHXDIYGCSLVFT
|
8.5 | IC50 | 4 | — | |
DRRXBDBWFYLFOH
|
8.5 | IC50 | 2 | — | |
GSQLJRMAXJKBMR
|
8.5 | IC50 | 2 | — | |
GTVAUPIBHVDGDF
|
8.5 | IC50 | 2 | — | |
JBSDBYXRHGAOIT
|
8.5 | IC50 | 2 | — | |
NWZQTNDYDHXMOE
|
8.5 | IC50 | 3 | — | |
CFKLRZPAONERNA
|
8.4 | IC50 | 2 | — | |
CHBBYOIXEZCTDF
|
8.4 | IC50 | 2 | — | |
CIPVUQSDDVFBPO
|
8.4 | IC50 | 3 | — | |
CPKOOPNFOWNEFT
|
8.4 | IC50 | 2 | — | |
GJDYHVMPMKOHGG
|
8.4 | IC50 | 3 | — | |
GQWVZXYZPPWMNU
|
8.4 | IC50 | 4 | — | |
OELHXJQUNXVIPN
|
8.4 | IC50 | 2 | — | |
BPKVTDLMFZLJIM
|
8.4 | IC50 | 2 | — | |
IKXRBNYJGLGKNN
|
8.4 | IC50 | 2 | — | |
KXLRVRIKQJRVCZ
|
8.4 | IC50 | 2 | Yes | |
NYHCGCDSBXKURV
|
8.4 | IC50 | 2 | — | |
TYPAATJNKNDNOD
|
8.4 | IC50 | 2 | Yes | |
YJJIOYPSLPQCAL
|
8.4 | IC50 | 2 | Yes | |
ZMYUKKKHJVNBAM
|
8.4 | IC50 | 5 | Yes | |
AJCVQFHDDPYHTQ
|
8.4 | IC50 | 2 | — | |
ATEQNOXHLBHSBB
|
8.4 | IC50 | 2 | Yes | |
BIHYRPIDCXHQKD
|
8.4 | IC50 | 3 | — | |
CNQREVSEDFUJPZ
|
8.4 | IC50 | 2 | — | |
CREMXLIEDCOOOC
|
8.4 | IC50 | 2 | Yes | |
DFJSJLGUIXFDJP
|
8.4 | IC50 | 9 | — | |
DTNINSLBWVYZJC
|
8.4 | IC50 | 2 | — | |
FTHVRWNSFRDQNV
|
8.4 | IC50 | 2 | — |