Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CRKDDCRCAGBCAI
|
8.6 | IC50 | 2 | — | |
QTDAKIJYNHGZGQ
|
8.6 | IC50 | 2 | — | |
UHGKHVDHBHYHFY
|
8.6 | IC50 | 2 | — | |
HFSSHOGNUBJRFO
|
8.6 | IC50 | 2 | — | |
HGQXZYPOEYQQSH
|
8.6 | IC50 | 2 | — | |
NVVASLWKXTZLJN
|
8.6 | IC50 | 3 | Yes | |
RCQQOUGGIYVAKT
|
8.6 | IC50 | 2 | Yes | |
SNHCRNMVYDHVDT
|
8.6 | IC50 | 3 | — | |
XKPNZYKHLRMXRP
|
8.6 | IC50 | 2 | — | |
AAGKMGNYUYCEPD
|
8.5 | IC50 | 2 | — | |
AHRFAYIIMKQRQN
|
8.5 | IC50 | 2 | Yes | |
CRLFCKNBDNTEBA
|
8.5 | IC50 | 2 | — | |
DILPWWRXPRYDEA
|
8.5 | IC50 | 2 | — | |
DWLVUAOJOFAURW
|
8.5 | IC50 | 3 | Yes | |
KZBKXMGIJLJPHP
|
8.5 | IC50 | 2 | — | |
OVKAWEPHUVGRCJ
|
8.5 | IC50 | 2 | — | |
PKKRQPPSMXAKFM
|
8.5 | IC50 | 3 | Yes | |
RXCJZPBISMXQDN
|
8.5 | IC50 | 3 | — | |
XAHNKMWYZJATAR
|
8.5 | IC50 | 2 | — | |
YMFKLMVUBGVUPG
|
8.5 | IC50 | 2 | — | |
YMFKLMVUBGVUPG
|
8.5 | IC50 | 2 | — | |
NLSULBLCONKOIY
|
8.5 | IC50 | 2 | — | |
XPYMPMCHKMTXSB
|
8.5 | IC50 | 3 | — | |
ANBLNCFHLUIPFW
|
8.5 | IC50 | 2 | — | |
BJQOPTDJQILKBE
|
8.5 | IC50 | 2 | — | |
BJSZKHZJEOKFJO
|
8.5 | IC50 | 4 | Yes | |
BLJNPQMAXWOROS
|
8.5 | IC50 | 2 | — | |
CCUYECGXGAFGTM
|
8.5 | IC50 | 2 | — | |
DHYOUBFOTVVFGI
|
8.5 | IC50 | 2 | — | |
DVYJHGWNABVCHI
|
8.5 | IC50 | 2 | — | |
FTFRZXFNZVCRSK
|
8.5 | IC50 | 2 | Yes | |
GFNNBHLJANVSQV
|
8.5 | IC50 | 7 | Yes | |
GUWSUDKDQHKWGK
|
8.5 | IC50 | 2 | — | |
GYCAMAWPCOYTTF
|
8.5 | IC50 | 2 | Yes | |
HXMKNGQXLJHQDQ
|
8.5 | IC50 | 2 | Yes | |
IAOXZLAUYRRAPL
|
8.5 | IC50 | 2 | — | |
IOUSSSXSMQFGSU
|
8.5 | IC50 | 2 | — | |
JCMIPNLNEAFFHI
|
8.5 | IC50 | 2 | — | |
JNCKWWADGCZZGL
|
8.5 | IC50 | 2 | Yes | |
JUGSLZCFNSTKBN
|
8.5 | IC50 | 2 | — | |
MSSFKFFUKSRZMQ
|
8.5 | IC50 | 3 | — | |
MTZNLMGFYVEIAP
|
8.5 | IC50 | 2 | — | |
MVLNKEXGMMGTDC
|
8.5 | IC50 | 2 | — | |
NFWFBDDHXYCYHP
|
8.5 | IC50 | 2 | — | |
NXSMOWZBERTEAU
|
8.5 | IC50 | 2 | Yes | |
OMYOVWAUIIJSPG
|
8.5 | IC50 | 3 | Yes | |
QINSOUANYOEWLZ
|
8.5 | IC50 | 2 | — | |
QQUJEUGNKCSQPP
|
8.5 | Ki | 2 | — | |
RAKHTNLGXMUAQG
|
8.5 | IC50 | 2 | Yes | |
RMZISWVBRKVMOJ
|
8.5 | IC50 | 2 | — |