Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZQAIYVKPDMZOOX
|
8.7 | IC50 | 2 | Yes | |
ZROBAJVGRYCCGH
|
8.7 | IC50 | 2 | Yes | |
ZUXMJIHRFCSCKH
|
8.7 | IC50 | 2 | — | |
PKGJEJSOPQZJNR
|
8.7 | IC50 | 2 | — | |
RHNCTEJANSMRNV
|
8.7 | IC50 | 3 | Yes | |
SNGQUXXOIHSAPK
|
8.7 | IC50 | 13 | Yes | |
FHOMWNVSSMYQJF
|
8.7 | IC50 | 2 | — | |
BMBAFWOVSWBDSJ
|
8.7 | IC50 | 2 | — | |
DNZYOZKYEXTOPJ
|
8.7 | IC50 | 16 | Yes | |
DYEJNTSLXASZEI
|
8.7 | IC50 | 2 | — | |
WUOFCZPJKYPFBV
|
8.7 | IC50 | 3 | — | |
YHCWZWFXNSGDTJ
|
8.7 | IC50 | 2 | — | |
ARFRDHRNFVIREW
|
8.7 | IC50 | 2 | — | |
RYJUBUAQXKSUDZ
|
8.7 | IC50 | 2 | — | |
GCKTWBJEXJWFHY
|
8.6 | IC50 | 18 | — | |
GQKBKXCKNKSJGG
|
8.6 | IC50 | 2 | — | |
MCVGYROQTOADFC
|
8.6 | IC50 | 2 | — | |
MWNASUNUUFWMNK
|
8.6 | IC50 | 4 | — | |
SWOLBBOITSRBEP
|
8.6 | IC50 | 3 | — | |
UUFDRURWKKKAJF
|
8.6 | IC50 | 4 | Yes | |
VCFRCVFKCUBENM
|
8.6 | IC50 | 2 | — | |
ZGLKRNQYRQCDLQ
|
8.6 | IC50 | 2 | — | |
ZJLGUUXMOOWUTC
|
8.6 | IC50 | 2 | — | |
YSTSGFGNZVLCQE
|
8.6 | IC50 | 2 | — | |
FUCZYDBKFNOERW
|
8.6 | IC50 | 3 | — | |
HCDQNNHFLOPNLM
|
8.6 | IC50 | 2 | — | |
PLIVFNIUGLLCEK
|
8.6 | IC50 | 20 | Yes | |
WGERYIXXYKWSML
|
8.6 | IC50 | 2 | — | |
MVZGYPSXNDCANY
|
8.6 | IC50 | 3 | — | |
TUYDDIWQXWTNSW
|
8.6 | IC50 | 2 | — | |
YJAJTLZIWHYGPF
|
8.6 | IC50 | 3 | — | |
BTYYWOYVBXILOJ
|
8.6 | IC50 | 4 | Yes | |
DKMXEBIKMPYHST
|
8.6 | IC50 | 2 | — | |
QIGGJMQSVPHSJB
|
8.6 | IC50 | 16 | Yes | |
AVHNHPHSQMBYAJ
|
8.6 | IC50 | 3 | — | |
DKOJJTJTHLDNCA
|
8.6 | IC50 | 2 | — | |
DPNQFVJNRXPIOB
|
8.6 | IC50 | 3 | — | |
LMXYVLFTZRPNRV
|
8.6 | IC50 | 8 | — | |
QTDAKIJYNHGZGQ
|
8.6 | IC50 | 2 | — | |
RFXHNJBBKBSDIB
|
8.6 | IC50 | 2 | — | |
SSAKQDBVDKDWIF
|
8.6 | IC50 | 3 | — | |
WGRLOIOBISATRO
|
8.6 | IC50 | 3 | — | |
BKPHBKMWPXFKCO
|
8.6 | IC50 | 2 | — | |
CEHWSHIRJLKBPD
|
8.6 | IC50 | 2 | — | |
CQFUQADMAQYBOB
|
8.6 | IC50 | 3 | — | |
HTUBKQUPEREOGA
|
8.6 | IC50 | 6 | Yes | |
JPHMUYSWHKPNKF
|
8.6 | IC50 | 2 | Yes | |
QJNMNCUMDUMIJV
|
8.6 | IC50 | 2 | — | |
XLPVELDHLJITBK
|
8.6 | IC50 | 2 | — | |
ZZKJYWJMKZJTKA
|
8.6 | IC50 | 2 | — |