Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
LPFWVDIFUFFKJU
|
8.8 | IC50 | 9 | — | |
LPOXCHABLAZUHB
|
8.8 | IC50 | 3 | — | |
MODKQWIWLUEOCI
|
8.8 | IC50 | 3 | — | |
QJJUWHGSXUKRET
|
8.8 | IC50 | 2 | — | |
BGXFUKVIYBKVKN
|
8.8 | IC50 | 2 | — | |
PJWKUTKNLNUGPO
|
8.8 | IC50 | 2 | — | |
PXBVPDIMCOILPS
|
8.8 | IC50 | 3 | Yes | |
YYFXDJZLXVIKOY
|
8.8 | IC50 | 2 | — | |
GJOOJNANCIXZSG
|
8.7 | IC50 | 2 | — | |
GONZJBXMEAMLKR
|
8.7 | IC50 | 2 | — | |
MDCWIVYFXQKDOP
|
8.7 | IC50 | 2 | Yes | |
QIMXUZNKIMFXLS
|
8.7 | IC50 | 2 | — | |
JDBWHHHWEABNEC
|
8.7 | IC50 | 4 | — | |
JWNPDZNEKVCWMY
|
8.7 | IC50 | 57 | Yes | |
MHRLVGRDCBMEMM
|
8.7 | IC50 | 2 | — | |
RBVREWVCSCUBOY
|
8.7 | IC50 | 2 | — | |
TWMBIUXHLWHJHL
|
8.7 | IC50 | 2 | — | |
FKXXCQSSSCJHOZ
|
8.7 | IC50 | 3 | Yes | |
BTYFROXGYQVTDB
|
8.7 | IC50 | 2 | — | |
BXQSENVZNNEEBV
|
8.7 | IC50 | 5 | Yes | |
DIBGTMXGHUALIU
|
8.7 | IC50 | 2 | — | |
FFMBLUIQUJAMEE
|
8.7 | IC50 | 2 | — | |
FFMVKPOWYKTXJH
|
8.7 | IC50 | 2 | — | |
FHVKRQBYJHSTOF
|
8.7 | IC50 | 2 | — | |
IHZHFIKEGVXLHF
|
8.7 | IC50 | 2 | Yes | |
IUNORHVEZRZFIC
|
8.7 | IC50 | 2 | — | |
IXWWFHBAOSNFBD
|
8.7 | IC50 | 13 | Yes | |
JPUWTGYAJVCPPC
|
8.7 | IC50 | 2 | — | |
KPUXYKMAEDAWET
|
8.7 | IC50 | 2 | — | |
LDDDGIHXYBWEAR
|
8.7 | IC50 | 2 | — | |
LWXXXBLCUHRMAR
|
8.7 | IC50 | 3 | — | |
MLXUDJPUEMLBKJ
|
8.7 | IC50 | 2 | — | |
NWTMVEULVXKTGX
|
8.7 | IC50 | 2 | — | |
OBPBWDICVLAZAK
|
8.7 | Ki | 2 | — | |
OEFWUILIMFIVSE
|
8.7 | IC50 | 2 | — | |
QBXOTLALTCSTEQ
|
8.7 | IC50 | 2 | — | |
QQLKULDARVNMAL
|
8.7 | IC50 | 4 | — | |
RRBYOZUVIOQSSM
|
8.7 | IC50 | 2 | Yes | |
SOYOGGAXHRNJSO
|
8.7 | IC50 | 2 | — | |
SRUYMJRFVGLQDV
|
8.7 | Ki | 37 | — | |
SUPFKVRCENJLNR
|
8.7 | IC50 | 2 | — | |
TYZVQDKPFGAICT
|
8.7 | IC50 | 2 | — | |
UGWUUDYHNSCFBW
|
8.7 | IC50 | 2 | — | |
UJBJAMOSBBJZBK
|
8.7 | IC50 | 6 | Yes | |
VDTSETQUTFVUDZ
|
8.7 | IC50 | 2 | — | |
WHZWIUHEEWZECR
|
8.7 | IC50 | 2 | — | |
WUDIBRLHJBOEBA
|
8.7 | Kd | 2 | — | |
WYQRWWCPRIGMCS
|
8.7 | IC50 | 6 | — | |
YFFQYUIFTHZMHX
|
8.7 | IC50 | 2 | — | |
YMMVVFFRNSLEMO
|
8.7 | IC50 | 2 | — |