Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JHZHWAOFJSCIEJ
|
9.0 | IC50 | 2 | Yes | |
NYYMSVYTUYTODA
|
9.0 | IC50 | 4 | — | |
OINWQMFPLYPJMF
|
9.0 | IC50 | 3 | — | |
RKUXMYUMMSWVGH
|
9.0 | IC50 | 2 | — | |
VNTCTQSZRPNAAH
|
8.9 | IC50 | 2 | — | |
ATEKSUDRIVWTTK
|
8.9 | IC50 | 4 | — | |
IQJPWAAWPFBLPZ
|
8.9 | IC50 | 2 | — | |
LYIUENVBACZSCL
|
8.9 | IC50 | 2 | — | |
NBPZAZKNOBYORP
|
8.9 | IC50 | 2 | — | |
QYNJVRUBTKSLBX
|
8.9 | IC50 | 4 | — | |
SXQLWNOERMLQGM
|
8.9 | IC50 | 3 | Yes | |
XKQMUBZLWVCRQI
|
8.9 | IC50 | 2 | — | |
XXPNVCKNJSDJBX
|
8.9 | IC50 | 2 | — | |
XYFPWWZEPKGCCK
|
8.9 | IC50 | 7 | — | |
ZAWWCTXYZTURLN
|
8.9 | IC50 | 4 | — | |
HIONRJFCDLKILS
|
8.9 | IC50 | 2 | Yes | |
LGOLZSGPACQCPU
|
8.9 | IC50 | 2 | — | |
KJRVCMVPIKELBC
|
8.9 | IC50 | 12 | — | |
SABATKMFVISBCV
|
8.9 | IC50 | 3 | — | |
SSQNYDRMXIRNEQ
|
8.9 | IC50 | 2 | — | |
XYFPWWZEPKGCCK
|
8.9 | IC50 | 7 | — | |
YBNQRDJFYLHMJK
|
8.9 | IC50 | 2 | — | |
YDBGJXSBVYKNNA
|
8.9 | IC50 | 2 | — | |
RCXKACUHTAVIBD
|
8.9 | IC50 | 2 | — | |
AWQLTDUXGVCRBV
|
8.9 | IC50 | 2 | Yes | |
OWTUZFHMSVAQSQ
|
8.9 | Ki | 2 | — | |
YXFCBQUDPXMRJR
|
8.9 | IC50 | 2 | Yes | |
GCUYIMVZVRRUPD
|
8.8 | IC50 | 3 | — | |
HRUMSDFICXUFED
|
8.8 | IC50 | 2 | — | |
MAJNIEIORMXOPT
|
8.8 | IC50 | 3 | — | |
OLGIXZUEHWJIST
|
8.8 | IC50 | 2 | — | |
PCOFCPRYWPQQMW
|
8.8 | IC50 | 2 | — | |
QJJUWHGSXUKRET
|
8.8 | IC50 | 3 | — | |
ZAJXXUDARPGGOC
|
8.8 | IC50 | 4 | — | |
MIHHASRXEFINIJ
|
8.8 | IC50 | 2 | — | |
DUQNNMZVFABECU
|
8.8 | IC50 | 2 | — | |
MWZFXIKIYVTOEE
|
8.8 | IC50 | 2 | — | |
NJHDYUHKGOBVKW
|
8.8 | IC50 | 2 | — | |
ZNRSOAIMVVRTJR
|
8.8 | IC50 | 2 | — | |
CYQSRZQWLBOOCC
|
8.8 | IC50 | 2 | — | |
JJHXVSSJRMTBMC
|
8.8 | IC50 | 3 | Yes | |
SCGBVARXTMVSJL
|
8.8 | IC50 | 2 | — | |
UIAARIUTYORWEV
|
8.8 | IC50 | 2 | Yes | |
ZIMAXJVJGIDWAX
|
8.8 | IC50 | 2 | — | |
WCHJBACVJHXLGX
|
8.8 | IC50 | 2 | — | |
CIGSBJHMSOROSY
|
8.8 | IC50 | 2 | Yes | |
HCVNIUYGKPAXGI
|
8.8 | IC50 | 2 | — | |
KYLTYWRKNDUYIL
|
8.8 | IC50 | 2 | — | |
YGVOTPAIXFJINL
|
8.8 | IC50 | 2 | — | |
AULSSQLQADCGRT
|
8.8 | IC50 | 2 | — |