Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SFSNVFCNLQLQLX
|
9.1 | IC50 | 4 | — | |
WRUDTZAASVCWAT
|
9.1 | IC50 | 2 | — | |
ZITZYNQSTDWKGI
|
9.1 | IC50 | 2 | — | |
FOOPCYOJMREECW
|
9.1 | IC50 | 5 | — | |
WDQXCAKHPJSZET
|
9.1 | IC50 | 3 | — | |
ATUXFPJRTSKHFB
|
9.0 | IC50 | 3 | — | |
OLYVUTGQXNIQQG
|
9.0 | IC50 | 2 | Yes | |
JFUDQORFBVGLMB
|
9.0 | IC50 | 3 | — | |
UHGKHVDHBHYHFY
|
9.0 | IC50 | 2 | — | |
VIANWBJPMVJZPN
|
9.0 | IC50 | 3 | Yes | |
ACFWCPZFEIDRAM
|
9.0 | IC50 | 2 | — | |
AKGBHBRPZOEXLG
|
9.0 | IC50 | 2 | — | |
BREQYZAUXDTBIU
|
9.0 | IC50 | 2 | — | |
BUGPWXMPCMTLIX
|
9.0 | IC50 | 7 | Yes | |
DRWSMZPVRXENHA
|
9.0 | IC50 | 3 | — | |
FQINJZOKZQVKKN
|
9.0 | IC50 | 2 | — | |
GOWVVIDXCJWUFJ
|
9.0 | IC50 | 2 | Yes | |
IKGZVVDUDQWXGP
|
9.0 | IC50 | 2 | — | |
JEQYQTIMESUCSU
|
9.0 | IC50 | 2 | — | |
JGSKJUYVTDKFKT
|
9.0 | IC50 | 3 | — | |
KJBZQIKLKWQVLL
|
9.0 | IC50 | 3 | — | |
KJTNEZSZMBPREH
|
9.0 | IC50 | 2 | — | |
LVTYOFSQYNYQPE
|
9.0 | IC50 | 2 | — | |
NBDUYVCAGYKHNT
|
9.0 | IC50 | 2 | — | |
OXEPBXIKNMTKJH
|
9.0 | IC50 | 2 | — | |
PDAORGBSUCRCDK
|
9.0 | IC50 | 2 | — | |
PQVBRHDKJDCOQV
|
9.0 | IC50 | 2 | — | |
RJFMUYZWDLSYSX
|
9.0 | IC50 | 2 | — | |
TUGBVZCJQUNZOM
|
9.0 | IC50 | 2 | — | |
ULUUNYJTTJIXHY
|
9.0 | IC50 | 2 | — | |
ULXXDDBFHOBEHA
|
9.0 | IC50 | 15 | Yes | |
UNTXLEZCEUSPFP
|
9.0 | IC50 | 2 | — | |
WVUNYSQLFKLYNI
|
9.0 | IC50 | 46 | Yes | |
XYUIVHYWMAPVBZ
|
9.0 | IC50 | 2 | Yes | |
YKJMMLPNQSTDLZ
|
9.0 | IC50 | 2 | — | |
YXIIIHIHDBMOTL
|
9.0 | IC50 | 2 | — | |
YZBXYPYYWUFAEL
|
9.0 | IC50 | 2 | — | |
ZHVASSKARGGGPC
|
9.0 | IC50 | 2 | — | |
ZOKDRCQALBIAIW
|
9.0 | IC50 | 2 | — | |
ZSCILBYYYABZHM
|
9.0 | IC50 | 2 | — | |
HGURWXVQNCHCIP
|
9.0 | IC50 | 2 | — | |
UJVYDMJHGODRML
|
9.0 | IC50 | 2 | — | |
WVPWMTUOJRIZIV
|
9.0 | IC50 | 2 | — | |
GFQMYECKUFYUSH
|
9.0 | IC50 | 2 | — | |
QPNJJRLONMTPQV
|
9.0 | IC50 | 2 | — | |
UEQMJDSTZLVUDP
|
9.0 | IC50 | 2 | — | |
DJAUDRYHVNOPNC
|
9.0 | IC50 | 2 | — | |
DUPJQTWIYRCOHX
|
9.0 | IC50 | 4 | — | |
HWBDLOPOEYLRKK
|
9.0 | IC50 | 4 | — | |
IJONDZVYIBNTDX
|
9.0 | IC50 | 3 | — |