Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YGFCGWOZJQMOOG
|
9.3 | IC50 | 2 | Yes | |
CXOPEXZCBUQYKF
|
9.3 | IC50 | 2 | — | |
LAGFSKLMDVYLMX
|
9.3 | IC50 | 3 | — | |
APEBZRPPOOOJJN
|
9.3 | IC50 | 2 | — | |
IBVURLSKTNUMDI
|
9.3 | IC50 | 2 | — | |
NECNOKMWRWJOGB
|
9.3 | IC50 | 2 | — | |
SGGCXJXLKGOOEM
|
9.3 | IC50 | 2 | — | |
CLJJOJZHQFORCB
|
9.3 | IC50 | 3 | — | |
CSSULGIISNOHGK
|
9.3 | IC50 | 2 | — | |
WIIOTLRKRPDWPS
|
9.3 | IC50 | 2 | — | |
MBJLGAXTBLLONX
|
9.3 | IC50 | 2 | — | |
YWIRFAISLJFQCK
|
9.3 | IC50 | 2 | — | |
LCYSSHSIKSARGO
|
9.3 | IC50 | 19 | — | |
VPBAXWOWGZTFTQ
|
9.3 | IC50 | 2 | — | |
WZVDJOCODASVRT
|
9.3 | IC50 | 2 | — | |
NAHITMMJENLIPQ
|
9.3 | IC50 | 2 | — | |
XMHOUJITNCFQRT
|
9.3 | IC50 | 2 | — | |
LKPIQEOIBNBGGY
|
9.3 | IC50 | 2 | — | |
RPEVJAKUNSLTDG
|
9.3 | IC50 | 2 | — | |
VCCJAEXPICPGMM
|
9.3 | IC50 | 3 | — | |
VFRPNIRNEYDCSJ
|
9.3 | IC50 | 2 | — | |
KTOOFDBYBSZFDL
|
9.2 | IC50 | 3 | — | |
WNGDCEKCMKAXBU
|
9.2 | Ki | 2 | — | |
KNXXEFGLJICDBL
|
9.2 | IC50 | 2 | Yes | |
GOAJIFLFYKGQGD
|
9.2 | IC50 | 2 | — | |
HDOYBSYHRJWGJH
|
9.2 | IC50 | 2 | — | |
LDBOHQXRMNACLS
|
9.2 | IC50 | 4 | — | |
MFPHQWFDPPWIFC
|
9.2 | IC50 | 2 | — | |
UAXLMFNKXDVZKH
|
9.2 | IC50 | 3 | — | |
XRTHZTMBMXYKBQ
|
9.2 | IC50 | 2 | — | |
DBDXRFYGZAEXEW
|
9.2 | IC50 | 2 | — | |
GYFAPMADUQCILZ
|
9.2 | IC50 | 5 | — | |
UIXUAKVMQUZXGY
|
9.2 | IC50 | 4 | — | |
WZDZUXUFHGWMFV
|
9.2 | IC50 | 2 | — | |
PBOJUVGISNLNHX
|
9.2 | IC50 | 2 | — | |
JTLIXOUWXJJHBC
|
9.1 | IC50 | 2 | — | |
ASJKJRLGRZGMDR
|
9.1 | IC50 | 2 | — | |
DXVUJULKKKBRPO
|
9.1 | IC50 | 2 | — | |
NRUJDQAGOKDQBH
|
9.1 | IC50 | 3 | — | |
PHBABPPOPBBETK
|
9.1 | IC50 | 2 | — | |
IFUPZYWAOYZTHS
|
9.1 | IC50 | 2 | — | |
FGYHOZIXSUEJDM
|
9.1 | IC50 | 3 | — | |
GQIUCZODBZCWCR
|
9.1 | IC50 | 2 | — | |
INURPMRKCUUSHP
|
9.1 | IC50 | 2 | — | |
HIQDSWJKNBQWTG
|
9.1 | IC50 | 2 | — | |
NXVZNVMICNOVJM
|
9.1 | IC50 | 2 | — | |
PUKITJOCVOEXLY
|
9.1 | IC50 | 2 | — | |
ZDZOTLJHXYCWBA
|
9.1 | Kd | 19 | — | |
XUVOOJLRVOEDJR
|
9.1 | IC50 | 2 | — | |
DLPSDPPZXRJQOY
|
9.1 | IC50 | 3 | Yes |