Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MNNXRVSQOABRRP
|
8.0 | IC50 | 2 | Yes | |
MOSUULXFKWELRP
|
8.0 | IC50 | 3 | — | |
NIGXIHUCIANGDC
|
8.0 | IC50 | 3 | — | |
OQNWVLNMDGADGP
|
8.0 | IC50 | 2 | — | |
OYAMULIHRWEUAR
|
8.0 | IC50 | 7 | Yes | |
PHKGTKKOFIGCOP
|
8.0 | IC50 | 2 | — | |
POGVJKDNNKLOEI
|
8.0 | IC50 | 2 | — | |
RKUHGVDFHLNNLT
|
8.0 | IC50 | 2 | — | |
RWBZRZZVHCQBPV
|
8.0 | IC50 | 2 | — | |
RZBKGDSTLKCOCW
|
8.0 | IC50 | 3 | — | |
SSYMKGVXLKENJR
|
8.0 | IC50 | 2 | Yes | |
VHGQJLWYOGRRAE
|
8.0 | IC50 | 4 | — | |
VJPOWWGOZASADR
|
8.0 | IC50 | 2 | — | |
WPKVIBFJECQBCV
|
8.0 | IC50 | 3 | — | |
WXUQFXPVDDHAIZ
|
8.0 | IC50 | 3 | — | |
ZCIXBBSRVLSRJQ
|
8.0 | IC50 | 2 | Yes | |
ZCIXBBSRVLSRJQ
|
8.0 | IC50 | 2 | — | |
ZTQLMGBKQNFQRU
|
8.0 | IC50 | 2 | — | |
FEOPLVISXFSHGK
|
8.0 | IC50 | 13 | Yes | |
GFQVWAVVNKSCBU
|
8.0 | IC50 | 3 | — | |
XPZGTHUXSPUGHN
|
8.0 | IC50 | 2 | — | |
ACNYXAIBELJFSP
|
8.0 | IC50 | 3 | — | |
AZLXGJFHSLQCPV
|
8.0 | IC50 | 2 | — | |
CPSNDIISTKABIL
|
8.0 | Ki | 2 | — | |
ILBOKEFXMPHJKP
|
8.0 | IC50 | 2 | — | |
JWNAINYXINYHML
|
8.0 | IC50 | 3 | — | |
ZOLXJDSFGCNIAL
|
8.0 | IC50 | 2 | — | |
OVNXJZUYPUTQOA
|
8.0 | IC50 | 2 | — | |
ZHSPHEJVKURUJP
|
8.0 | IC50 | 2 | — | |
AAKJLRGGTJKAMG
|
8.0 | IC50 | 50 | Yes | |
BLWDOLCMBQDSMT
|
8.0 | IC50 | 4 | — | |
HOUMQZGBNXSVNG
|
8.0 | IC50 | 3 | — | |
IWBVCRRXSCJLQC
|
8.0 | IC50 | 2 | Yes | |
JHRFCGXRLWMAKU
|
8.0 | IC50 | 2 | — | |
KZVDSZYFRUKCEQ
|
8.0 | IC50 | 3 | — | |
LHTOPXIXDAUXST
|
8.0 | IC50 | 3 | — | |
LPJIZDSOUGHTNB
|
8.0 | IC50 | 3 | — | |
MNHSNOFOOBXMPN
|
8.0 | IC50 | 2 | — | |
NNUTXHLBPVZZHN
|
8.0 | IC50 | 3 | — | |
RENFOOCUNGUUHO
|
8.0 | IC50 | 2 | — | |
RQUAEMCWWIFVCJ
|
8.0 | IC50 | 2 | — | |
RWZGZLPZVJTIAS
|
8.0 | IC50 | 2 | — | |
UGBDLAMFDOZLBT
|
8.0 | IC50 | 3 | — | |
UQTJNUFTALPBOP
|
8.0 | IC50 | 2 | — | |
UQTJNUFTALPBOP
|
8.0 | IC50 | 2 | — | |
UVBKNBPCVRBUTF
|
8.0 | IC50 | 5 | — | |
WLLKPDBSPXZCTG
|
8.0 | IC50 | 2 | Yes | |
WXUOMYZUSKPSJL
|
8.0 | IC50 | 2 | — | |
XGALLCVXEZPNRQ
|
8.0 | IC50 | 39 | Yes | |
XRGMUYHNNJZTJU
|
8.0 | IC50 | 2 | Yes |