Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JOJVJYUHAXMDPF
|
8.1 | IC50 | 2 | — | |
JTLHPKSZESHKCP
|
8.1 | IC50 | 4 | Yes | |
KKDYDBIEHYKZTL
|
8.1 | IC50 | 2 | — | |
MDSJWBBQCSEPDO
|
8.1 | IC50 | 2 | — | |
NHXPKHTXOWBCBM
|
8.1 | IC50 | 2 | Yes | |
OMVRJIWYIOEXTO
|
8.1 | IC50 | 3 | — | |
PBIJKZCHYCDPPC
|
8.1 | IC50 | 2 | Yes | |
PKVCAQKGXZUIDA
|
8.1 | IC50 | 2 | — | |
PNENUMJQDWNJEW
|
8.1 | IC50 | 2 | — | |
RGZXAQQHXALOBL
|
8.1 | Kd | 10 | — | |
SHRZDXFZUPQARN
|
8.1 | IC50 | 2 | — | |
UVBXNSDEQMCSMK
|
8.1 | IC50 | 2 | — | |
UVCZDNANYMDIHR
|
8.1 | IC50 | 2 | — | |
VKFHLVGNIPONMR
|
8.1 | IC50 | 2 | Yes | |
VOPNWXZDJKCCRE
|
8.1 | IC50 | 7 | Yes | |
XEWDTZOOQNFSOM
|
8.1 | IC50 | 2 | — | |
XVWIKDNFQMOLIX
|
8.1 | IC50 | 2 | — | |
YJELZTGEMAQGHU
|
8.1 | IC50 | 2 | — | |
YLOOVLOMQTYREV
|
8.1 | IC50 | 2 | — | |
YSXGNIUKUJNNPR
|
8.1 | IC50 | 2 | — | |
FXRLTQRMUHOCQN
|
8.0 | IC50 | 4 | — | |
KYZBBCJEGMZWLG
|
8.0 | IC50 | 2 | — | |
LSCYWBZWOOITKQ
|
8.0 | IC50 | 2 | — | |
OTIXNYWEVTWQKC
|
8.0 | IC50 | 2 | — | |
OYAHQWRTIPQZIR
|
8.0 | IC50 | 13 | Yes | |
PKVCAQKGXZUIDA
|
8.0 | IC50 | 2 | — | |
QYRNHUOFBYAKEW
|
8.0 | IC50 | 2 | — | |
WMGCDPLNGZVVCJ
|
8.0 | IC50 | 3 | — | |
XODLISJMYZQRRX
|
8.0 | IC50 | 2 | — | |
UCSIYDCODBRGKW
|
8.0 | IC50 | 13 | Yes | |
VJGCLZJLDHAMQI
|
8.0 | IC50 | 2 | — | |
GUHJZZKAWYPNAQ
|
8.0 | IC50 | 2 | — | |
NHCMWZMKRSNOCJ
|
8.0 | IC50 | 2 | — | |
OJZOATKRUUBXBM
|
8.0 | IC50 | 2 | — | |
SXBQBMPZTKSXKA
|
8.0 | Ki | 2 | — | |
YYNUBPUXFJKWOK
|
8.0 | IC50 | 4 | — | |
ZYLWPLCMORTKOJ
|
8.0 | IC50 | 2 | — | |
ZYQXEVJIFYIBHZ
|
8.0 | IC50 | 5 | — | |
ICDUDMAKDBBZOT
|
8.0 | IC50 | 3 | — | |
QZLBUBDMRGKXON
|
8.0 | IC50 | 2 | — | |
SEXLNNKPTDAAAL
|
8.0 | IC50 | 2 | — | |
SQOSPWRQEQEAIJ
|
8.0 | IC50 | 2 | — | |
WUAZUOXCWOXJJP
|
8.0 | IC50 | 2 | — | |
AARRKLWESWJSEE
|
8.0 | IC50 | 2 | — | |
BCFGMOOMADDAQU
|
8.0 | IC50 | 6 | Yes | |
CGRLNCABNBKKKW
|
8.0 | IC50 | 4 | — | |
HLWNQNFLDPUOHI
|
8.0 | IC50 | 2 | Yes | |
IWHGCJQTYUACSO
|
8.0 | IC50 | 2 | — | |
IYBCSQNVVICLIT
|
8.0 | IC50 | 3 | — | |
LKQWOHYTZVPINL
|
8.0 | IC50 | 2 | — |