Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ICKLZZYEDMBELM
|
8.2 | IC50 | 2 | — | |
QTRVZMFRXOALDJ
|
8.2 | IC50 | 3 | Yes | |
BGPAHUNSGVWHIG
|
8.2 | IC50 | 2 | — | |
QXIYODYFHMPKBX
|
8.2 | IC50 | 3 | — | |
RSJIZNRDILNEMO
|
8.2 | IC50 | 2 | — | |
RXVARTZYPOQZBI
|
8.2 | IC50 | 2 | — | |
UMWZSZYWDMVROC
|
8.2 | IC50 | 3 | Yes | |
XPTBKXUITCLALC
|
8.2 | IC50 | 2 | — | |
XYGJPSHVCKGCKO
|
8.2 | IC50 | 2 | — | |
DFDUYVRHGNUQHL
|
8.2 | IC50 | 2 | — | |
RFSXIPRAZZPVFM
|
8.2 | IC50 | 2 | — | |
RZJRJEDTYIELCA
|
8.2 | IC50 | 2 | — | |
XTWOENWSROIPBI
|
8.2 | IC50 | 4 | — | |
BEXPELAOVIOQHQ
|
8.2 | IC50 | 3 | Yes | |
CYJRTIWIUXKNTC
|
8.2 | IC50 | 2 | — | |
DYYZXRCFCVDSKD
|
8.2 | IC50 | 3 | Yes | |
FNYHTKUCTLSINN
|
8.2 | IC50 | 3 | Yes | |
FWRVTLDCKFPGCK
|
8.2 | IC50 | 2 | — | |
IRMHXRHXLFRZFM
|
8.2 | IC50 | 2 | — | |
KGHAUONMJSXUDW
|
8.2 | IC50 | 2 | Yes | |
LKFFEAZVODAFLR
|
8.2 | IC50 | 3 | — | |
MPNYXYMZXMXPMG
|
8.2 | IC50 | 3 | — | |
PITISSXVJPJKIL
|
8.2 | IC50 | 2 | — | |
PSRIIUUKNWOHQJ
|
8.2 | IC50 | 2 | — | |
QASOHECZVDQOIK
|
8.2 | IC50 | 2 | — | |
RHGWXTYSJLZTBJ
|
8.2 | IC50 | 2 | — | |
RRXSXSCXMPQLTP
|
8.2 | IC50 | 2 | Yes | |
SEHAPCZLZSSPLF
|
8.2 | IC50 | 2 | — | |
SMOPKEHQPPXRSH
|
8.2 | IC50 | 8 | — | |
SOCMOTGNRXRMOH
|
8.2 | IC50 | 13 | Yes | |
UWUFUUGZSOQBCY
|
8.2 | IC50 | 2 | Yes | |
UWXSAYUXVSFDBQ
|
8.2 | IC50 | 6 | — | |
UYFPHIJXUONCKX
|
8.2 | IC50 | 3 | — | |
VAMWYDFGORHXIU
|
8.2 | IC50 | 2 | — | |
WFPUKTYKJNILHS
|
8.2 | IC50 | 2 | — | |
XRZUOLFZBNANGA
|
8.2 | IC50 | 2 | Yes | |
YBQICLDGWWEPMS
|
8.2 | IC50 | 2 | — | |
ZAFWWWJOUAFSJP
|
8.2 | IC50 | 2 | Yes | |
ZOGNMJNQBLFBPT
|
8.2 | IC50 | 2 | Yes | |
BYYWPKXODYXSLS
|
8.1 | IC50 | 2 | — | |
JMIAHUUVJVWQPL
|
8.1 | IC50 | 2 | — | |
MXDSJQHFFDGFDK
|
8.1 | IC50 | 5 | — | |
NWDHKEKOJHPRMD
|
8.1 | IC50 | 2 | — | |
VEQYCEHJTJSHLO
|
8.1 | IC50 | 4 | — | |
XGNXYCZBBNAIIL
|
8.1 | IC50 | 3 | — | |
KAQHUJGJYUUQSI
|
8.1 | IC50 | 2 | — | |
LNRFTLQUUQAWMM
|
8.1 | Kd | 4 | Yes | |
YKNNKGNQGPFRTQ
|
8.1 | IC50 | 2 | — | |
CZLTXJVPEMCPLP
|
8.1 | IC50 | 2 | — | |
FOBRPXRJBHDKKT
|
8.1 | IC50 | 2 | — |