Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RMAWTLGYTCCDFL
|
8.3 | IC50 | 2 | — | |
YBEIPHUFRFGXCJ
|
8.3 | IC50 | 4 | — | |
YFBBPYBKOLENKT
|
8.3 | IC50 | 2 | — | |
BKGAQRNSVMXWHB
|
8.3 | IC50 | 2 | — | |
KIKYDYDKITYLHU
|
8.3 | IC50 | 2 | — | |
SVRFIUCPQRDGOA
|
8.3 | IC50 | 2 | — | |
IUZQUGLOCXBWCX
|
8.2 | IC50 | 2 | — | |
NSDAIDHIWWAWPP
|
8.2 | Ki | 2 | — | |
VDYDWBHVRSRTJM
|
8.2 | IC50 | 2 | — | |
XYFPWWZEPKGCCK
|
8.2 | IC50 | 34 | — | |
ZBGGBRQHYYAQQU
|
8.2 | IC50 | 2 | — | |
HNFWPMOZPVUYBB
|
8.2 | IC50 | 4 | — | |
PCOFCPRYWPQQMW
|
8.2 | IC50 | 2 | — | |
QXIYODYFHMPKBX
|
8.2 | IC50 | 2 | — | |
VQLJIZZYDFSRTB
|
8.2 | IC50 | 3 | — | |
BLDCWEIZHXYOIX
|
8.2 | IC50 | 2 | — | |
CNRMVFRKCDVXKW
|
8.2 | IC50 | 3 | — | |
FGPPXNCHKYRZCI
|
8.2 | IC50 | 6 | — | |
LHMPUXRYZHNWOO
|
8.2 | IC50 | 2 | — | |
VARKGQPOASCLDR
|
8.2 | IC50 | 2 | — | |
WVDAQTVGUQLXLW
|
8.2 | IC50 | 2 | Yes | |
DJURWFMQIHTKEM
|
8.2 | IC50 | 2 | — | |
DTGDQRLXHBUCRM
|
8.2 | IC50 | 5 | Yes | |
LOCGWCWPUSRMSW
|
8.2 | IC50 | 2 | — | |
LVXJQMNHJWSHET
|
8.2 | IC50 | 7 | — | |
OTMPOVZNMVTURI
|
8.2 | IC50 | 2 | Yes | |
PHBGPFOCLNZBNW
|
8.2 | IC50 | 2 | — | |
RIFKDQITWFTYJS
|
8.2 | IC50 | 2 | — | |
TVQHGTHLBVLBIA
|
8.2 | IC50 | 3 | Yes | |
UVEBHXRRTIKHPI
|
8.2 | IC50 | 2 | — | |
ZKRKJAPDCNQMCJ
|
8.2 | IC50 | 2 | Yes | |
FGBWIPBEKQBXCP
|
8.2 | IC50 | 2 | — | |
LFINNXTUHOXVQV
|
8.2 | IC50 | 2 | — | |
MIEFOWWVTPYZSU
|
8.2 | IC50 | 2 | — | |
NZFZJXGMCMWQJQ
|
8.2 | IC50 | 2 | — | |
UGZVJMYKCCZXOJ
|
8.2 | IC50 | 3 | Yes | |
CLULIRQIGKTNOX
|
8.2 | IC50 | 2 | — | |
FEUDQBUFXPUTKC
|
8.2 | IC50 | 2 | — | |
FKSFPUSFMMAXPK
|
8.2 | IC50 | 2 | — | |
IFAAYTNDJIPJBZ
|
8.2 | IC50 | 2 | — | |
REGOTSLWVKSZRG
|
8.2 | IC50 | 2 | — | |
UXFMBILQHOZKAC
|
8.2 | IC50 | 2 | — | |
WZZXMNBOPNKKSX
|
8.2 | Ki | 10 | — | |
XDYCDXFDVOBDOO
|
8.2 | IC50 | 2 | Yes | |
CXFZABYZQCUWPA
|
8.2 | IC50 | 3 | — | |
GFMMDHSSOIPFTF
|
8.2 | IC50 | 2 | — | |
IGXWHXJCDUCSBX
|
8.2 | IC50 | 2 | — | |
OLURIASFBDWIAK
|
8.2 | IC50 | 2 | Yes | |
SIMOEFIOKHUVBO
|
8.2 | Ki | 2 | — | |
XMHFNOVIKVSOEA
|
8.2 | IC50 | 3 | — |