Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KAJAEDXGWXUDJX
|
8.3 | IC50 | 2 | — | |
KZBKXMGIJLJPHP
|
8.3 | IC50 | 2 | — | |
OFQRNJAHCAMAME
|
8.3 | IC50 | 2 | — | |
PXGDIYNZVLBJPI
|
8.3 | IC50 | 2 | — | |
SUBNLERWESOYMX
|
8.3 | IC50 | 4 | Yes | |
JFBQFAKGLQJGIL
|
8.3 | IC50 | 3 | — | |
JXMVENNOZUEFQY
|
8.3 | IC50 | 18 | — | |
RLWORZOMJGXPLR
|
8.3 | IC50 | 2 | — | |
ZJWIQVGGKBBVCV
|
8.3 | IC50 | 2 | — | |
ADQFBAMWKUTCQJ
|
8.3 | IC50 | 2 | — | |
AHKADPGTHXIDQX
|
8.3 | IC50 | 2 | — | |
APHSPKWGAGCFBE
|
8.3 | IC50 | 2 | Yes | |
BDGBUNQPUJHMAM
|
8.3 | IC50 | 2 | — | |
BFSRTTWIPACGMI
|
8.3 | IC50 | 4 | — | |
BZUIGXZUUGQBLL
|
8.3 | IC50 | 2 | Yes | |
DXHVWHPBMGIYNQ
|
8.3 | IC50 | 2 | Yes | |
GNIFAULXFNJRKN
|
8.3 | IC50 | 4 | — | |
ITTRLTNMFYIYPA
|
8.3 | IC50 | 17 | — | |
IXKNBAGOTATIPL
|
8.3 | IC50 | 2 | — | |
JKAXXKYYTNYYGM
|
8.3 | IC50 | 2 | Yes | |
LJKPCPFZGRKCSR
|
8.3 | IC50 | 2 | — | |
MFBTVPWNHQVGPL
|
8.3 | IC50 | 2 | Yes | |
NHWFEYYJOLZGNB
|
8.3 | IC50 | 6 | Yes | |
PBOYHYLBDARXMU
|
8.3 | IC50 | 2 | — | |
PDLBTPKSQYCOOT
|
8.3 | IC50 | 2 | — | |
QJDVRSWQZWVVQW
|
8.3 | IC50 | 2 | — | |
QMXMLFJONMTABH
|
8.3 | IC50 | 2 | — | |
QXIOZIFTPMAING
|
8.3 | IC50 | 17 | — | |
RDSINGBRTMDIHM
|
8.3 | IC50 | 2 | — | |
RSNNOUWADQQHGE
|
8.3 | IC50 | 2 | — | |
SDVCOWGIPMODEC
|
8.3 | IC50 | 18 | — | |
SXEYAAMYAQFZGM
|
8.3 | IC50 | 2 | — | |
TZDAEWGVZVGBPE
|
8.3 | IC50 | 2 | — | |
ULXXDDBFHOBEHA
|
8.3 | IC50 | 2 | — | |
VQXONFAAUSCWAP
|
8.3 | IC50 | 2 | Yes | |
VTLQAHPWBDJOFR
|
8.3 | IC50 | 2 | — | |
WXPDCELKHNMODS
|
8.3 | IC50 | 3 | Yes | |
YOHNLHXVSFTRLR
|
8.3 | IC50 | 2 | — | |
LWHLXGYSDDYOMY
|
8.3 | IC50 | 3 | — | |
ONGVIYPMHRIZEX
|
8.3 | IC50 | 3 | — | |
PINKRWLMLPSIJO
|
8.3 | IC50 | 2 | — | |
QXMGDURKHOLKQW
|
8.3 | IC50 | 3 | — | |
FESKVIPHVGGMNZ
|
8.3 | IC50 | 2 | — | |
HKPCGWWALFPRSS
|
8.3 | IC50 | 2 | — | |
JXWQISPUKBAERI
|
8.3 | IC50 | 2 | — | |
UAKCSDXRUMEJCU
|
8.3 | IC50 | 2 | — | |
XHVDNUGMYNEUDS
|
8.3 | IC50 | 2 | Yes | |
XWIIFWOMOTZBMM
|
8.3 | IC50 | 2 | — | |
ZMKCTDCBEVQDJK
|
8.3 | IC50 | 2 | — | |
BJGUNGDUBFAZJF
|
8.3 | IC50 | 18 | — |