Target Details
| UniProt AC | P00533 |
|---|---|
| Gene Symbol | EGFR |
| Protein Name | Epidermal growth factor receptor |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00757 (Furin-like) PF14843 (GF_recep_IV) PF07714 (PK_Tyr_Ser-Thr) PF01030 (Recep_L_domain) PF21314 (TM_ErbB1) |
Summary
- Multi-target molecules 3,433
- Clinical molecules 833
- Avg pChEMBL 7.29
KEGG Pathways (51)
- Adherens junction
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH signaling pathway
- HIF-1 signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human papillomavirus infection
- Integrin signaling
- JAK-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Shigellosis
- Virion - Hepatitis viruses
Associated Diseases (12)
Active Molecules (3,433)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CKHBRJUFFWJVQL
|
10.1 | IC50 | 2 | — | |
NAUMQOWVCNOPGB
|
10.0 | IC50 | 2 | — | |
ZVCRDGKVDBJYMB
|
10.0 | IC50 | 2 | — | |
KTUFNOKKBVMGRW
|
10.0 | IC50 | 38 | Yes | |
WAYSVGLDKMEZLH
|
9.9 | IC50 | 2 | — | |
PCKCQQLBJXBCNU
|
9.9 | IC50 | 4 | — | |
YFQGFLOTVWXVMG
|
9.9 | IC50 | 2 | — | |
NNFDRCGXLJTASH
|
9.8 | IC50 | 4 | — | |
FBHYBOKWBSZCDR
|
9.8 | IC50 | 2 | — | |
FMZRZFFJJZHENK
|
9.8 | IC50 | 2 | — | |
HZBHTRUJNPPRNW
|
9.8 | IC50 | 2 | — | |
XHZSUEXQZOQCLO
|
9.8 | IC50 | 2 | — | |
LVLFSSZNAIKYCD
|
9.8 | IC50 | 19 | — | |
GJOMMDPXVSZLQK
|
9.7 | IC50 | 2 | — | |
LHHLPNVJMCVRGH
|
9.7 | IC50 | 2 | — | |
ASEMLWDIYZJALH
|
9.7 | IC50 | 2 | — | |
MJLGATKKRYTQPD
|
9.7 | IC50 | 3 | — | |
OHRLRZXRCWVJGT
|
9.7 | IC50 | 3 | — | |
JPJAUHSLJCUGAH
|
9.7 | IC50 | 4 | — | |
UGQSWPUGVJABLU
|
9.6 | IC50 | 3 | — | |
OMTLURFNGXKURR
|
9.6 | IC50 | 2 | — | |
UNTXLEZCEUSPFP
|
9.6 | IC50 | 2 | — | |
XHHRYYIEFNUMAA
|
9.6 | IC50 | 2 | — | |
MCNVTWIIWNZMGB
|
9.6 | IC50 | 2 | — | |
YBLBBOHIJOJAPV
|
9.6 | IC50 | 4 | — | |
ZDRUKZASWZMRRR
|
9.6 | IC50 | 2 | — | |
CJRAVDZBPHZSKH
|
9.5 | IC50 | 3 | — | |
HCVNIUYGKPAXGI
|
9.5 | IC50 | 2 | — | |
HVXKQKFEHMGHSL
|
9.5 | IC50 | 21 | — | |
JFFNMSINEFWPKX
|
9.5 | IC50 | 2 | — | |
SKKIKHFBSXYTQB
|
9.5 | IC50 | 2 | — | |
HZBHTRUJNPPRNW
|
9.5 | IC50 | 2 | — | |
KFHMLBXBRCITHF
|
9.5 | IC50 | 2 | — | |
BDFBZODVIHQKRH
|
9.5 | IC50 | 2 | — | |
XSONJYMNNFECBU
|
9.4 | IC50 | 2 | — | |
CIGDLWJIFWLWPZ
|
9.4 | IC50 | 2 | — | |
VPBAXWOWGZTFTQ
|
9.4 | IC50 | 2 | — | |
GZHCSTJUZKGLGS
|
9.4 | IC50 | 2 | — | |
SJYYQCWAHXFERH
|
9.4 | IC50 | 3 | — | |
YAPFODKXVWEFPW
|
9.4 | IC50 | 3 | — | |
BYSBLMVAHXUQDT
|
9.4 | IC50 | 2 | — | |
CBHNKMDPARMMCD
|
9.4 | IC50 | 2 | — | |
IQJPWAAWPFBLPZ
|
9.4 | IC50 | 2 | — | |
JEMSOXTWRRHLSY
|
9.4 | IC50 | 2 | — | |
OZRNZXPMNJNRPE
|
9.4 | IC50 | 2 | — | |
YXOXHAUUTIOBDA
|
9.4 | IC50 | 3 | Yes | |
OZFQDKCCDUEPFK
|
9.4 | IC50 | 3 | — | |
OMZCMEYTWSXEPZ
|
9.4 | IC50 | 43 | Yes | |
CBPCSPAXUJCCML
|
9.3 | IC50 | 2 | — | |
WQIVPDKBAHQPEF
|
9.3 | IC50 | 2 | — |