Target Details
| UniProt AC | P00403 |
|---|---|
| Gene Symbol | MT-CO2 |
| Protein Name | Cytochrome c oxidase subunit 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00116 (COX2) PF02790 (COX2_TM) |
Summary
- Multi-target molecules 8
- Clinical molecules 2
- Avg pChEMBL 6.79
KEGG Pathways (13)
- Alzheimer disease
- Amyotrophic lateral sclerosis
- Cardiac muscle contraction
- Chemical carcinogenesis - reactive oxygen species
- Diabetic cardiomyopathy
- Huntington disease
- Metabolic pathways
- Non-alcoholic fatty liver disease
- Oxidative phosphorylation
- Parkinson disease
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Thermogenesis
Associated Diseases (1)
Active Molecules (8)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RZJQGNCSTQAWON
|
7.7 | IC50 | 3 | — | |
AJFTZWGGHJXZOB
|
7.7 | IC50 | 3 | — | |
MWKSRKSEWLRPBL
|
6.8 | Kd | 1075 | — | |
CGIGDMFJXJATDK
|
6.7 | IC50 | 11 | Yes | |
RZEKVGVHFLEQIL
|
6.5 | IC50 | 21 | Yes | |
SHAHPWSYJFYMRX
|
6.5 | IC50 | 4 | — | |
ZCCPLJOKGAACRT
|
6.3 | Kd | 599 | — | |
PQVXNOUEEGFMNE
|
6.0 | IC50 | 2 | — |