Target Details
| UniProt AC | O95819 |
|---|---|
| Gene Symbol | MAP4K4 |
| Protein Name | Mitogen-activated protein kinase kinase kinase kinase 4 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00780 (CNH) PF00069 (Pkinase) |
Summary
- Multi-target molecules 496
- Clinical molecules 34
- Avg pChEMBL 6.84
KEGG Pathways (1)
Active Molecules (496)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OKFYOOFXVBCIIP
|
9.4 | Ki | 2 | — | |
HKSZLNNOFSGOKW
|
9.2 | IC50 | 408 | — | |
HKSZLNNOFSGOKW
|
8.8 | Ki | 118 | — | |
HYUGTGGDEAGXJP
|
8.6 | IC50 | 11 | — | |
JIYNLLZDWHPTOM
|
8.5 | Ki | 5 | — | |
KNACLJBHKVSTDL
|
8.5 | Ki | 40 | — | |
PTZQSGFNHIVQKV
|
8.5 | Ki | 8 | — | |
BERZRFJWHSXBCR
|
8.4 | Ki | 7 | — | |
BSFNGHCTZDCQBF
|
8.4 | Ki | 93 | — | |
JMHQUQCLIVNTHT
|
8.4 | Ki | 24 | — | |
PWIKZIKRKUUHRB
|
8.4 | Ki | 9 | — | |
SRBGKBONVVVORP
|
8.4 | IC50 | 2 | — | |
BPSYQQWLXMMBAX
|
8.3 | IC50 | 2 | — | |
NWMPVMMGSHXANZ
|
8.3 | Ki | 58 | — | |
BYWYWLKBKIJAAJ
|
8.2 | IC50 | 2 | — | |
BGYVWFZMYBWCNY
|
8.2 | Ki | 30 | — | |
BPNUQXPIQBZCMR
|
8.2 | Ki | 60 | — | |
LPILBMJJRGTKOQ
|
8.2 | Ki | 27 | — | |
VXYDJXMHISGSDA
|
8.2 | Ki | 59 | — | |
QJWIVNXPZLGILT
|
8.2 | IC50 | 2 | — | |
LSLPDHNUWRDOGC
|
8.1 | Ki | 25 | — | |
OADRBDVURCEKRP
|
8.1 | Ki | 44 | — | |
UBPYILGKFZZVDX
|
8.1 | Kd | 130 | Yes | |
DKTMRIORKQEKMU
|
8.0 | Ki | 10 | — | |
SMRWVXLSRJWVBF
|
8.0 | Ki | 25 | — | |
UQJQNZHGEVLHST
|
8.0 | Ki | 15 | — | |
VVUATAXJOVGUSR
|
8.0 | IC50 | 2 | — | |
HNWRRPTZWUVJAX
|
8.0 | IC50 | 2 | — | |
KDJJXBPORVAUEF
|
7.9 | IC50 | 2 | — | |
GCZJQTRRJPRFIP
|
7.9 | Ki | 10 | — | |
PUYIXDDMOUMMRR
|
7.9 | Ki | 27 | — | |
SIABUCJHEMLWDM
|
7.9 | IC50 | 2 | — | |
SLKCVFPEQGHNSI
|
7.9 | Ki | 29 | — | |
ZGGIYFOLDBTZIL
|
7.9 | Ki | 27 | — | |
WWWPDUVJHFVGOK
|
7.9 | IC50 | 2 | — | |
ZGCQRUODVWMXSM
|
7.9 | IC50 | 2 | — | |
ODPGGGTTYSGTGO
|
7.8 | Kd | 153 | — | |
RJZAPAMXDXCITJ
|
7.8 | IC50 | 2 | — | |
FLEAYYMORDPWAJ
|
7.8 | Ki | 90 | — | |
LACOMQAWPSFXQC
|
7.8 | Ki | 27 | — | |
UDRXOUVRNMKWQA
|
7.8 | Ki | 8 | — | |
YJBNTRQKJQHMTM
|
7.8 | Ki | 11 | — | |
JHZZTEODBVPOGC
|
7.8 | IC50 | 2 | — | |
YUVLZPSSXDFUHH
|
7.7 | IC50 | 3 | — | |
ZTSOUDMNSOYCTG
|
7.7 | IC50 | 10 | — | |
KOZFSFOOLUUIGY
|
7.7 | Kd | 88 | Yes | |
KEBXAEFZLCNLJJ
|
7.7 | Ki | 13 | — | |
LCHCSKHPVCDXAU
|
7.7 | Ki | 30 | — | |
MNEBTNXXCJJUOW
|
7.7 | Ki | 7 | — | |
RQJIDUOCLNMUHR
|
7.7 | Ki | 15 | — |