Target Details
| UniProt AC | O95622 |
|---|---|
| Gene Symbol | ADCY5 |
| Protein Name | Adenylate cyclase type 5 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16214 (AC_N) PF06327 (Adcy_cons_dom) PF00211 (Guanylate_cyc) |
Summary
- Multi-target molecules 23
- Clinical molecules 0
- Avg pChEMBL 7.63
KEGG Pathways (57)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Apelin signaling pathway
- Bile secretion
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Melanogenesis
- Metabolic pathways
- Morphine addiction
- Neuroactive ligand signaling
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Phospholipase D signaling pathway
- Platelet activation
- Progesterone-mediated oocyte maturation
- Purine metabolism
- Rap1 signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Thermogenesis
- Thyroid hormone synthesis
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (2)
Active Molecules (23)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AMFHYXNMOKDWIW
|
9.1 | Ki | 9 | — | |
AMFHYXNMOKDWIW
|
8.8 | Ki | 9 | — | |
AMFHYXNMOKDWIW
|
8.8 | Ki | 9 | — | |
AMFHYXNMOKDWIW
|
8.7 | Ki | 9 | — | |
PHGNXIOXPJPSGT
|
8.6 | Ki | 9 | — | |
URFLLMOKPBTOSX
|
8.6 | Ki | 9 | — | |
HXLZHGSDMHVARV
|
8.4 | Ki | 9 | — | |
PACPSUFYRVUEPS
|
8.4 | Ki | 9 | — | |
XNELKPKYCQGGFW
|
8.1 | IC50 | 2 | — | |
BMLKVCTUWHHDAJ
|
8.1 | Ki | 9 | — | |
YFBXBYGXHKOXOG
|
7.8 | Ki | 10 | — | |
PADIVHKPYLHTDY
|
7.8 | Ki | 10 | — | |
KHJHACWGMCPAEX
|
7.7 | Ki | 10 | — | |
DCXARCKEWAQLJB
|
7.5 | Ki | 10 | — | |
GQPPIAAXSZCKMB
|
7.3 | Ki | 10 | — | |
XNNDVZWCQPPMHC
|
7.0 | Ki | 10 | — | |
FPOPGDWXBFUBKQ
|
6.8 | Ki | 10 | — | |
BZXMLCVDKDXRQY
|
6.6 | Ki | 11 | — | |
OIKPHPKYVGTXMU
|
6.5 | Ki | 10 | — | |
CWDASHXSVSFWKM
|
6.5 | Ki | 10 | — | |
JTIOTPJAIFIFFX
|
6.2 | Ki | 10 | — | |
XUMJJSAQQCTKAO
|
6.2 | Kd | 3 | — | |
AUEUQGHVNOSGSL
|
6.0 | Ki | 10 | — |