Target Details
| UniProt AC | O75676 |
|---|---|
| Gene Symbol | RPS6KA4 |
| Protein Name | Ribosomal protein S6 kinase alpha-4 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 60
- Clinical molecules 15
- Avg pChEMBL 6.93
KEGG Pathways (2)
Active Molecules (60)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FYXRSVDHGLUMHB
|
8.2 | IC50 | 8 | — | |
MHGPJIHGGLSWFD
|
8.1 | IC50 | 8 | — | |
ZCCPLJOKGAACRT
|
8.1 | Kd | 599 | — | |
IEQAHFTVGLZUBI
|
8.0 | IC50 | 8 | — | |
HKSZLNNOFSGOKW
|
8.0 | IC50 | 408 | — | |
IIRWNGPLJQXWFJ
|
7.9 | IC50 | 21 | — | |
XQVVPGYIWAGRNI
|
7.9 | Kd | 34 | — | |
AFZXKZNWMHCMPD
|
7.7 | IC50 | 2 | — | |
KAKGFGCTONHQJW
|
7.7 | Ki | 25 | — | |
LOLPPWBBNUVNQZ
|
7.6 | IC50 | 97 | Yes | |
RSFBRAHCHZGZPB
|
7.5 | IC50 | 8 | — | |
BPNUQXPIQBZCMR
|
7.4 | Ki | 60 | — | |
NHHQJBCNYHBUSI
|
7.4 | Kd | 220 | — | |
MPVGZUGXCQEXTM
|
7.3 | Ki | 61 | Yes | |
KGPGFQWBCSZGEL
|
7.3 | Kd | 59 | Yes | |
UIARLYUEJFELEN
|
7.2 | Kd | 289 | Yes | |
WINHZLLDWRZWRT
|
7.2 | Ki | 66 | — | |
MFAQYJIYDMLAIM
|
7.2 | Kd | 130 | Yes | |
YOBIWCLAYQWPPW
|
7.2 | IC50 | 23 | — | |
KKKRKRMVJRHDMG
|
7.1 | Kd | 14 | — | |
LXPVLMCYPWKNBD
|
7.1 | IC50 | 2 | — | |
PTVPBWWDGZSEAF
|
7.1 | Ki | 63 | — | |
GLDSKRNGVVYJAB
|
7.0 | Kd | 16 | — | |
SGZZQKMOFHIDKW
|
7.0 | Kd | 13 | — | |
MWKSRKSEWLRPBL
|
7.0 | Kd | 1075 | — | |
WINHZLLDWRZWRT
|
7.0 | Kd | 201 | Yes | |
HIUHVDROHDSKTC
|
7.0 | Ki | 20 | — | |
PYXQMJSGJIJHJT
|
7.0 | Ki | 28 | — | |
SPMHGQZFMNZCBV
|
7.0 | Ki | 30 | Yes | |
AYCPARAPKDAOEN
|
7.0 | Kd | 73 | — | |
DKZYXHCYPUVGAF
|
7.0 | Kd | 112 | — | |
HKSZLNNOFSGOKW
|
6.9 | Kd | 213 | — | |
SEVCBWKJSOLMNQ
|
6.9 | Ki | 38 | — | |
JOOXLOJCABQBSG
|
6.8 | Kd | 139 | — | |
JYYLVUFNAHSSFE
|
6.8 | Kd | 9 | — | |
RYYNGWLOYLRZLK
|
6.8 | Kd | 45 | — | |
GMYYMEOGFRKSFS
|
6.8 | Ki | 29 | — | |
PUPCRRRSBUYJAD
|
6.8 | Ki | 44 | Yes | |
CTNPALGJUAXMMC
|
6.7 | Kd | 151 | — | |
LCGSWTFWYNYUKS
|
6.7 | Ki | 26 | — | |
NRGYZNJPCGRCLV
|
6.7 | Ki | 52 | — | |
GEGCXGMFUYJULA
|
6.6 | Ki | 30 | Yes | |
LGHBDVLAHHANMX
|
6.6 | Ki | 53 | — | |
BMGQWWVMWDBQGC
|
6.6 | Kd | 91 | Yes | |
BMGQWWVMWDBQGC
|
6.6 | Kd | 147 | Yes | |
HFNKQEVNSGCOJV
|
6.5 | Kd | 65 | — | |
KOZFSFOOLUUIGY
|
6.4 | Kd | 88 | Yes | |
QDITZBLZQQZVEE
|
6.3 | Kd | 19 | — | |
PIQCTGMSNWUMAF
|
6.2 | Kd | 137 | Yes | |
XZXHXSATPCNXJR
|
6.2 | Kd | 165 | Yes |