Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DKTMRIORKQEKMU
|
8.1 | Ki | 10 | — | |
DRRUMZPUGPNKLX
|
8.1 | IC50 | 5 | — | |
GHPFQRTVUDXWCC
|
8.1 | Ki | 35 | — | |
GVOJSDSHNFLVIW
|
8.1 | IC50 | 2 | — | |
HEESYZLXEJDLJI
|
8.1 | IC50 | 4 | — | |
HVRDUSBQYQFLOU
|
8.1 | IC50 | 2 | — | |
KQGQDDJOYKZFPV
|
8.1 | IC50 | 8 | — | |
LGBQXUXQAZHKOI
|
8.1 | IC50 | 2 | — | |
MCRBBYMYLBISCB
|
8.1 | IC50 | 2 | — | |
PFOOXZQINUSRCD
|
8.1 | IC50 | 6 | — | |
PNNANOOTMGLECQ
|
8.1 | IC50 | 2 | — | |
RHLKDYGYAZQPER
|
8.1 | IC50 | 2 | — | |
SLKCVFPEQGHNSI
|
8.1 | Ki | 29 | — | |
TZHNCJLXHRBGIF
|
8.1 | IC50 | 2 | — | |
UFRZVVLEFMQDSZ
|
8.1 | IC50 | 2 | — | |
UOMBBRLBZANHQY
|
8.1 | IC50 | 2 | — | |
XJVGQDMDOVIHME
|
8.1 | IC50 | 6 | — | |
XRCQVMGYIXAQNO
|
8.1 | IC50 | 2 | — | |
YWTBGJGMTBHQTM
|
8.1 | Ki | 65 | — | |
CJGPSZKKXISGIT
|
8.1 | IC50 | 2 | — | |
GUIBMJRAVIMUQK
|
8.1 | IC50 | 2 | — | |
WOFYXBWCKCYGFB
|
8.1 | Ki | 4 | — | |
XNOBXYSDKGIVFG
|
8.1 | IC50 | 2 | — | |
GMKAERKZQVDXFL
|
8.1 | IC50 | 2 | — | |
ZNGHRZYYUDIWDX
|
8.1 | IC50 | 2 | — | |
BZVQOZIIWUBEPH
|
8.1 | Ki | 3 | — | |
GUOHCRYZNLVGBD
|
8.1 | IC50 | 2 | — | |
ABPSPQITFLVJSN
|
8.1 | IC50 | 2 | — | |
BETBNWGUKZUUAX
|
8.1 | IC50 | 21 | — | |
BOAXHGZLIGFEMG
|
8.1 | IC50 | 2 | — | |
BSULSXCQOXQGND
|
8.1 | IC50 | 2 | — | |
FVUVFVFIFFZGSO
|
8.1 | IC50 | 2 | — | |
GLQHHAZRNIGZMU
|
8.1 | IC50 | 2 | — | |
JLWTUPLIJAHTKE
|
8.1 | IC50 | 3 | — | |
LXQGBVWOYPFPJU
|
8.1 | IC50 | 2 | — | |
MGSFSBWPBXVAEQ
|
8.1 | IC50 | 2 | — | |
NKWSAYGUIMPROA
|
8.1 | IC50 | 10 | — | |
PZUHTMLHMMXBQW
|
8.1 | IC50 | 2 | — | |
QZFJGJOKFAXJGE
|
8.1 | IC50 | 2 | — | |
SPMLNRHNYBYMMZ
|
8.1 | IC50 | 2 | — | |
UXIGAYGUDGBPOS
|
8.1 | IC50 | 6 | — | |
YXEHUEYJWPQYII
|
8.1 | IC50 | 3 | — | |
UVDICPSQYBDYJS
|
8.0 | IC50 | 2 | — | |
ADMZUAQDCHMTRI
|
8.0 | IC50 | 2 | — | |
CGXOKVWAHQLXGW
|
8.0 | IC50 | 2 | — | |
HYPWCTFOMRALRT
|
8.0 | IC50 | 2 | — | |
NIYRFURQRFEWPT
|
8.0 | IC50 | 2 | — | |
BKCNFBWOOAHROL
|
8.0 | IC50 | 3 | — | |
QWQSSMVCJVZYQX
|
8.0 | Ki | 3 | — | |
AOMUHYVRSKACNP
|
8.0 | Ki | 3 | — |