Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QJADABDCFYXZDB
|
8.2 | Ki | 2 | — | |
SOEYUSIWHOBEMJ
|
8.2 | IC50 | 2 | — | |
HOKFQGROLDNJSI
|
8.2 | IC50 | 2 | — | |
MVTQJLVXODOUEE
|
8.2 | IC50 | 2 | — | |
PHWHNHYZZNJPLB
|
8.2 | IC50 | 6 | Yes | |
WSXKSMSBOLIXMK
|
8.2 | IC50 | 2 | — | |
DWWGQXYDCWJWKM
|
8.2 | IC50 | 2 | — | |
FCAWOAVSJMHLKM
|
8.2 | IC50 | 2 | — | |
LRNKGINCBWKQIS
|
8.2 | IC50 | 2 | — | |
LRNKGINCBWKQIS
|
8.2 | IC50 | 2 | — | |
JBAFISIOKGNSRP
|
8.2 | IC50 | 2 | — | |
JJTVMBJRPZIZDA
|
8.2 | IC50 | 4 | — | |
CICZGTVNSVVRFC
|
8.2 | IC50 | 2 | — | |
COYVFENBIAJDFY
|
8.2 | IC50 | 2 | — | |
FAUXLGJPBACBAU
|
8.2 | IC50 | 2 | — | |
FKFKNJHNUIUXHO
|
8.2 | Ki | 3 | — | |
GNPISLOHLRSZHY
|
8.2 | IC50 | 4 | — | |
HCJBFYQKXGZALI
|
8.2 | IC50 | 2 | — | |
IIRWSDZCKFCCRO
|
8.2 | IC50 | 2 | — | |
JIKVGTFJHKLPJM
|
8.2 | IC50 | 2 | — | |
KUZSZZVWEJIXDN
|
8.2 | IC50 | 2 | — | |
LIYNJKNSBUCWCZ
|
8.2 | Kd | 3 | — | |
LKVWXTDYMZEGFK
|
8.2 | IC50 | 2 | — | |
LOSQCHDKQMEASF
|
8.2 | IC50 | 2 | — | |
MHOIPADYLYCBEO
|
8.2 | IC50 | 2 | — | |
MLSJLNVTEFJNLQ
|
8.2 | IC50 | 2 | — | |
RVYJKUWZLONOCK
|
8.2 | IC50 | 2 | — | |
XCUCJAJWXMJKLB
|
8.2 | IC50 | 2 | — | |
YRUQDRPCBLCNLP
|
8.2 | IC50 | 2 | — | |
BBZVXUBFCDUWHJ
|
8.1 | IC50 | 2 | — | |
QKKGSTFAKMXWFE
|
8.1 | IC50 | 3 | — | |
SNUDLLACDRMNDB
|
8.1 | IC50 | 6 | — | |
UARARIOSCGMOEN
|
8.1 | IC50 | 2 | — | |
MRSCRUMYAVOXFF
|
8.1 | IC50 | 2 | — | |
XSYRIOMWWLBTDE
|
8.1 | IC50 | 2 | — | |
HPUIONZOLCECJV
|
8.1 | IC50 | 2 | — | |
SWQDUVOIJJCWIG
|
8.1 | Ki | 4 | — | |
ZSMVURLDUKAKHA
|
8.1 | IC50 | 2 | — | |
IMZIJLMIOSQRGE
|
8.1 | IC50 | 2 | — | |
KXQPBSLMZVNGEV
|
8.1 | IC50 | 2 | — | |
LFJFWJSDSCDXIT
|
8.1 | IC50 | 2 | — | |
OYUCUEABSDSADC
|
8.1 | Ki | 3 | — | |
VYWFLGVPKXPOKG
|
8.1 | IC50 | 2 | — | |
ZFDYBUAPZQQBIX
|
8.1 | IC50 | 2 | — | |
ACSYKUPGCXYRRO
|
8.1 | Ki | 26 | — | |
AWDORCFLUJZUQS
|
8.1 | Ki | 22 | — | |
BGMFLWUQWMTTSW
|
8.1 | IC50 | 8 | — | |
BGYVWFZMYBWCNY
|
8.1 | Ki | 30 | — | |
BSULSXCQOXQGND
|
8.1 | IC50 | 2 | — | |
DFEBLGYTZYBLCJ
|
8.1 | IC50 | 2 | — |