Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XMFUGSRATNLPRM
|
8.3 | Ki | 19 | — | |
ZEBTVUQBWJLGIO
|
8.3 | IC50 | 2 | — | |
ZYBXRSQAQUYTFT
|
8.3 | IC50 | 2 | — | |
FCWLESDKJOPDNI
|
8.3 | IC50 | 2 | — | |
PATAJJRKSXHPFR
|
8.3 | IC50 | 2 | — | |
XYYBJOIYCJYCLA
|
8.3 | IC50 | 2 | — | |
DOLYBFURUMOFFO
|
8.3 | IC50 | 2 | — | |
GLYMNXIYEPWMQN
|
8.3 | IC50 | 2 | — | |
GRPWDTTUPAQJKP
|
8.3 | IC50 | 2 | — | |
YAGRGEPEYURZTE
|
8.3 | IC50 | 2 | — | |
YKCPIOFQNXOLHH
|
8.3 | IC50 | 2 | — | |
BFMOUERLZRRSFP
|
8.2 | IC50 | 2 | — | |
ITMSRNJKTCZBKP
|
8.2 | IC50 | 2 | — | |
ONZAMBWLADUDER
|
8.2 | IC50 | 2 | — | |
GXZFDXZCJALHRF
|
8.2 | IC50 | 6 | — | |
HXOGWFKVKCOUQG
|
8.2 | IC50 | 3 | — | |
OURRXQUGYQRVML
|
8.2 | IC50 | 2 | — | |
WTLKHNCRMWMEPP
|
8.2 | IC50 | 2 | — | |
CEUGVFZOIFRDQZ
|
8.2 | IC50 | 2 | — | |
ZTHAJPGZRABKDJ
|
8.2 | IC50 | 6 | — | |
BPKLWGGNPZJROD
|
8.2 | IC50 | 2 | — | |
FHISAROGPSYNME
|
8.2 | Ki | 10 | — | |
GDVRVPIXWXOKQO
|
8.2 | IC50 | 10 | — | |
HRELGTDDFADJJJ
|
8.2 | IC50 | 2 | — | |
IBDDMLHLHUWMJA
|
8.2 | IC50 | 2 | — | |
KCQPEINYMIEKJO
|
8.2 | IC50 | 2 | — | |
KSDORXSBAJOQKH
|
8.2 | Ki | 3 | — | |
NENOOZASAODLIG
|
8.2 | IC50 | 2 | — | |
OPSKOBJDDUDMAW
|
8.2 | IC50 | 2 | — | |
PXLAOJRRWUJJHK
|
8.2 | IC50 | 2 | — | |
QYGFMWMXWCEAQQ
|
8.2 | IC50 | 2 | — | |
RPLBFKLSRUYWQR
|
8.2 | IC50 | 2 | — | |
TZXXWAVRQLLEQF
|
8.2 | IC50 | 2 | — | |
UJMWLNFJHNEYBI
|
8.2 | IC50 | 2 | — | |
YFZKQJYONASWFW
|
8.2 | IC50 | 7 | — | |
ZDTUVVAJVVQVOT
|
8.2 | IC50 | 4 | — | |
ICBYDYURLUCFTP
|
8.2 | IC50 | 2 | — | |
YBJGEWMEAJHWTP
|
8.2 | IC50 | 2 | — | |
YQNABEYXJZNPEV
|
8.2 | Ki | 2 | — | |
AOCOKHUKZZVZDX
|
8.2 | IC50 | 2 | — | |
KEBXAEFZLCNLJJ
|
8.2 | Ki | 13 | — | |
LTFFYNBBYLBAGX
|
8.2 | IC50 | 2 | — | |
NOKBFRMKWIPMQW
|
8.2 | IC50 | 2 | — | |
SIKMVWPMDNIKAY
|
8.2 | IC50 | 2 | — | |
YGEACCLUBSGMMJ
|
8.2 | Ki | 16 | — | |
BOJODXOBEKPFNV
|
8.2 | Ki | 4 | — | |
FKYWIAWIDUIWFG
|
8.2 | IC50 | 2 | — | |
GZVUGIYFFYQNCJ
|
8.2 | Ki | 4 | — | |
HUXWDCVBFRJBIH
|
8.2 | Ki | 3 | — | |
PDYFIAVDSXKHGQ
|
8.2 | Ki | 2 | — |