Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
PASSAYPELLITCR
|
8.4 | IC50 | 2 | — | |
RBSPMMLWEZLNPN
|
8.4 | IC50 | 2 | — | |
RFVBRKXQYUDGIO
|
8.4 | Ki | 23 | — | |
ROHCLNJJGADSEF
|
8.4 | IC50 | 2 | — | |
SCIFUGGHOXNSJC
|
8.4 | IC50 | 2 | — | |
SDWJCHAEHSUYNZ
|
8.4 | IC50 | 2 | — | |
SEJXTFIDDFUTMH
|
8.4 | IC50 | 2 | — | |
SIYJLMVIVBKINW
|
8.4 | IC50 | 2 | — | |
XBFAFSAUQFDEOK
|
8.4 | IC50 | 5 | — | |
XYZNKCSDQRKAFR
|
8.4 | Ki | 53 | — | |
YOVNFNXUCOWYSG
|
8.4 | IC50 | 33 | Yes | |
ZUJRYKFJARKTIO
|
8.4 | IC50 | 3 | — | |
AXYUJGNZTZSFQB
|
8.4 | Ki | 2 | — | |
RPCURYQRJHATFZ
|
8.4 | IC50 | 2 | — | |
CPNKDRYVQOIHBT
|
8.4 | IC50 | 2 | — | |
OTJJLFCJBNJDPE
|
8.4 | Ki | 4 | — | |
OURRXQUGYQRVML
|
8.4 | Ki | 2 | — | |
DNAXPHDUUNPFLH
|
8.4 | IC50 | 2 | — | |
OBYJQKZNRUOYGF
|
8.4 | Ki | 2 | — | |
BTNHOAWDPXMJLS
|
8.4 | Ki | 4 | — | |
FQYIMRXBBCWILN
|
8.4 | IC50 | 2 | — | |
OADCLEGMNAVWGX
|
8.4 | IC50 | 2 | — | |
RJXSCRRYUBZADY
|
8.4 | IC50 | 2 | — | |
YUXHVLCKVCBVIZ
|
8.3 | IC50 | 7 | — | |
KTVRJTYYMLXASQ
|
8.3 | IC50 | 2 | — | |
MFBHZMTZVKYMTG
|
8.3 | IC50 | 2 | — | |
MZBLKPUSLVWLBU
|
8.3 | IC50 | 2 | — | |
ZNDQOACBIHODQO
|
8.3 | IC50 | 3 | — | |
LAOGZDNNZIJACP
|
8.3 | IC50 | 2 | — | |
PPHSCZQMXMHEGU
|
8.3 | IC50 | 2 | — | |
YTWFPZPOMPBTKV
|
8.3 | Ki | 4 | — | |
NSQJYQIGGJGUKK
|
8.3 | IC50 | 2 | — | |
NVHVDZKSZLWUNH
|
8.3 | IC50 | 5 | — | |
ZCFDZMIXMIEOHC
|
8.3 | IC50 | 6 | — | |
BNOZGVNRDKHRJQ
|
8.3 | IC50 | 2 | — | |
BTFXRESVGZYZQN
|
8.3 | IC50 | 2 | — | |
FJCVQMSTNYMHPK
|
8.3 | IC50 | 2 | — | |
HBZTVQKHXVDIDE
|
8.3 | Ki | 9 | — | |
LBVAPUMJWBSQAC
|
8.3 | IC50 | 2 | — | |
NSQDEFOCIHUFJM
|
8.3 | IC50 | 4 | — | |
NXLSASWJJYWMJP
|
8.3 | IC50 | 2 | — | |
OXWFDKJEHLGZPM
|
8.3 | IC50 | 2 | — | |
PGYLYUYINPOJLP
|
8.3 | IC50 | 2 | — | |
QXUHEZFLKIFWOJ
|
8.3 | IC50 | 2 | — | |
RINUIXSHMABIND
|
8.3 | IC50 | 2 | — | |
TZGDXUFTIVMJQY
|
8.3 | IC50 | 2 | — | |
UYRZRWDVJAODCA
|
8.3 | IC50 | 2 | — | |
VGNKOJURPOHWJF
|
8.3 | Ki | 21 | — | |
VRZUDQNRTCEYKK
|
8.3 | IC50 | 2 | — | |
XHIGXQJTNWSSII
|
8.3 | IC50 | 2 | — |