Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FXVIJUPKVPPUNX
|
8.5 | IC50 | 2 | — | |
GRCSRBVHHUZIOU
|
8.5 | IC50 | 2 | — | |
MBEYXNMHPBPYSU
|
8.5 | IC50 | 3 | — | |
MGSFSBWPBXVAEQ
|
8.5 | IC50 | 2 | — | |
MHFWDTZIDHQBTC
|
8.5 | IC50 | 2 | — | |
OQWZIAVXCYIZNN
|
8.5 | IC50 | 2 | — | |
PNGGDJQCOFAGPU
|
8.5 | IC50 | 2 | — | |
VVLBZWIAAVKYHB
|
8.5 | IC50 | 2 | — | |
WVGDUQVQWLHVEA
|
8.5 | IC50 | 4 | — | |
YJMNZRBIDTUOAU
|
8.5 | IC50 | 2 | — | |
ZCWWQXJFVPYXDZ
|
8.5 | IC50 | 2 | — | |
ZGCMTTQGRJYCEP
|
8.5 | IC50 | 2 | — | |
ZUJRYKFJARKTIO
|
8.5 | IC50 | 3 | — | |
CLRFYTGANQZOBS
|
8.5 | Ki | 41 | — | |
LOCWELCIOZHZHE
|
8.5 | Ki | 11 | — | |
MLGGUGPIWDHBAI
|
8.5 | Ki | 33 | — | |
PUYIXDDMOUMMRR
|
8.5 | Ki | 27 | — | |
JSBFPPNKJVBJKX
|
8.5 | IC50 | 2 | — | |
FDFPXMUSBROKPG
|
8.5 | IC50 | 2 | — | |
PDWFMHXAWIQAEE
|
8.5 | IC50 | 2 | — | |
VGRBFVDNFGSMNW
|
8.5 | IC50 | 3 | — | |
KKFYJBLOJFXLCI
|
8.5 | IC50 | 2 | — | |
CRFSDZNCOBDRQG
|
8.5 | IC50 | 2 | — | |
FKLDWZRWKZTOCJ
|
8.5 | IC50 | 7 | — | |
JHZUXOVQEXDSPY
|
8.5 | IC50 | 2 | — | |
KSEWBEGMKXXEAT
|
8.5 | IC50 | 2 | — | |
FDNZNHRDINDRLM
|
8.4 | IC50 | 2 | — | |
JTVBXQAYBIJXRP
|
8.4 | IC50 | 20 | — | |
KXPTUMLQPMMHGT
|
8.4 | IC50 | 4 | — | |
DPJRGWXPXGPHGL
|
8.4 | IC50 | 2 | — | |
SHZBLRCXYAENEO
|
8.4 | IC50 | 2 | — | |
DYGFSCBDKCOJFV
|
8.4 | Kd | 3 | — | |
MVIAXVXTYFEURX
|
8.4 | Kd | 3 | — | |
AJPKXMJSUPWNPX
|
8.4 | IC50 | 2 | — | |
CYJWEDGBZCTVAV
|
8.4 | IC50 | 2 | — | |
FMPKTXNCNJCHCC
|
8.4 | Ki | 25 | — | |
HOYRWTWZUFFACV
|
8.4 | Ki | 28 | — | |
IFSJHRROANUFFS
|
8.4 | IC50 | 2 | — | |
IHJPYWIDHOPLCK
|
8.4 | IC50 | 2 | — | |
JBMYKCXOEFHKCT
|
8.4 | IC50 | 2 | — | |
KGLFDWWHRVKBQU
|
8.4 | IC50 | 2 | — | |
KGOAUGHDPHDYBB
|
8.4 | IC50 | 2 | — | |
LNOMUGHAHOAATL
|
8.4 | IC50 | 2 | — | |
MHEUJRRHWZGOLM
|
8.4 | IC50 | 2 | — | |
MSNCQZSMEDHJLV
|
8.4 | IC50 | 2 | — | |
MURRHZDIBOUBHB
|
8.4 | IC50 | 7 | — | |
NGDNKYRUKIPCLK
|
8.4 | Ki | 12 | — | |
NLDHEYLJTMKCDH
|
8.4 | IC50 | 2 | — | |
OPCMBLPHMAXTTE
|
8.4 | IC50 | 2 | — | |
OPMIJOFRYUMESR
|
8.4 | IC50 | 2 | — |