Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
PHRUWSDSXOMMTK
|
8.7 | IC50 | 2 | — | |
ZKQKBOWBNMYREE
|
8.7 | IC50 | 2 | — | |
GWBRWSIUAMTBNQ
|
8.6 | IC50 | 2 | — | |
HSCQYWDDHGGJSS
|
8.6 | IC50 | 2 | — | |
MKOLBFDKJXCKJK
|
8.6 | IC50 | 2 | — | |
QPUSVMCWHCAZMN
|
8.6 | Ki | 2 | — | |
OEYSQZKVMVAGLO
|
8.6 | IC50 | 2 | — | |
LAIYLGVPZPZFRQ
|
8.6 | Ki | 2 | — | |
MEGGDKYEQSCVTG
|
8.6 | IC50 | 2 | — | |
QJQSUURRBCTTST
|
8.6 | Ki | 2 | — | |
URYCVJWDQPAEFD
|
8.6 | IC50 | 2 | — | |
UXSQCNYVZULXEF
|
8.6 | Ki | 2 | — | |
CVOQFIXUFCBSSC
|
8.6 | IC50 | 2 | — | |
DWZCDSLYZDTWQH
|
8.6 | IC50 | 5 | — | |
JDIAOFCAAPMAGG
|
8.6 | Ki | 4 | — | |
MVLPNSPQDDEIPU
|
8.6 | Ki | 2 | — | |
NSFLMMYRDFGKMW
|
8.6 | IC50 | 2 | — | |
AJFYMCKXLCRURF
|
8.6 | IC50 | 5 | — | |
BBJXVAVUGRNQFP
|
8.6 | IC50 | 5 | — | |
HMBSHDURLZEMQP
|
8.6 | IC50 | 2 | — | |
HNXJWWRRSGDVIW
|
8.6 | Ki | 13 | — | |
ICHFSXPUXZFBPH
|
8.6 | IC50 | 2 | — | |
JAGCQTZNUQROMH
|
8.6 | IC50 | 2 | — | |
JXMYIDZREHNPDO
|
8.6 | Ki | 19 | — | |
NCQQZIOVNVXPQY
|
8.6 | IC50 | 4 | — | |
SBMIMRGGSPVOAG
|
8.6 | IC50 | 2 | — | |
UVPTTYAFVRRFMP
|
8.6 | IC50 | 3 | — | |
XUFLBSMTYMFOQH
|
8.6 | Ki | 43 | — | |
ZQYPIHNDLBYJOW
|
8.6 | IC50 | 2 | — | |
CXWOMMUYWIPPCD
|
8.6 | IC50 | 2 | — | |
VBRGZHZCCDMLQY
|
8.6 | IC50 | 2 | — | |
FCDBVNCRKMBDIO
|
8.6 | IC50 | 2 | — | |
RLIFPWWQKDVDLP
|
8.6 | IC50 | 2 | — | |
WAOPBAUYEVWLHE
|
8.6 | IC50 | 2 | — | |
CYPOEEIUKVOVGO
|
8.6 | IC50 | 2 | — | |
INDDLVHMKCQKDP
|
8.6 | IC50 | 2 | — | |
GCKIJVYMPZVOFI
|
8.6 | IC50 | 2 | — | |
ICQSNTDFCNRKLY
|
8.6 | IC50 | 2 | — | |
MAAJGIGLUACQAJ
|
8.6 | IC50 | 3 | — | |
NRSGWEVTVGZDFC
|
8.6 | IC50 | 50 | — | |
STUSYRQGNZOVSJ
|
8.6 | IC50 | 2 | — | |
DFXUOVUWCCNNPV
|
8.5 | IC50 | 2 | — | |
KXFSTXOGNHZERD
|
8.5 | IC50 | 2 | — | |
FCAFTJDYTVBVRW
|
8.5 | IC50 | 2 | — | |
PLIFSXNZAOLLSV
|
8.5 | IC50 | 2 | — | |
YSVQULSJUHTXBG
|
8.5 | IC50 | 2 | — | |
AHOPLZOKZVFDJT
|
8.5 | IC50 | 2 | — | |
BXUCQKDKSJSLDL
|
8.5 | IC50 | 2 | — | |
CIPXFTLGPVQJKN
|
8.5 | IC50 | 2 | — | |
CVJDWPOZUNTTIU
|
8.5 | IC50 | 2 | — |