Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WHGWETKOANDIKB
|
8.9 | IC50 | 2 | — | |
LXQGBVWOYPFPJU
|
8.9 | IC50 | 2 | — | |
UYQVTFFVWVLMAA
|
8.9 | IC50 | 2 | — | |
HWOQGLLRJCPMIZ
|
8.9 | IC50 | 2 | — | |
DUUFTCDTPYSKCS
|
8.9 | IC50 | 2 | — | |
IESPMZJZNJRTEE
|
8.9 | Ki | 2 | — | |
SEPHKODFYBTYDV
|
8.9 | IC50 | 2 | — | |
JRVSFZKYQCETAH
|
8.8 | IC50 | 5 | — | |
MTZPPYMBIBCZBH
|
8.8 | IC50 | 2 | — | |
ZKQKBOWBNMYREE
|
8.8 | IC50 | 2 | — | |
FCVSCBFMVWNZGA
|
8.8 | IC50 | 2 | — | |
URCYWTVGSLLYNQ
|
8.8 | IC50 | 2 | — | |
YEYGCAOMGAHTST
|
8.8 | IC50 | 2 | — | |
ABEOBJODDVJCGS
|
8.8 | IC50 | 2 | — | |
BAUSMWQMIOODMY
|
8.8 | IC50 | 2 | — | |
BKKKAMZWSRIKDA
|
8.8 | IC50 | 2 | — | |
FFJWOJIKTPHFRY
|
8.8 | IC50 | 2 | — | |
WSXKSMSBOLIXMK
|
8.8 | IC50 | 2 | — | |
PNGGDJQCOFAGPU
|
8.8 | IC50 | 2 | — | |
UPRMJRLIYMEINE
|
8.8 | IC50 | 2 | — | |
MBFDUQROVSLSPJ
|
8.8 | IC50 | 2 | — | |
QKBCOPJTWMBBPN
|
8.8 | Ki | 2 | — | |
GRUQPKMQXSFMIX
|
8.7 | IC50 | 2 | — | |
SOGKOUURZPAQPP
|
8.7 | IC50 | 6 | — | |
UUJGSCUKYQKPHU
|
8.7 | IC50 | 2 | — | |
IKBDBMJIRDOTCY
|
8.7 | IC50 | 2 | — | |
KQDDDWVLLDDHOF
|
8.7 | IC50 | 2 | — | |
BMIATOZOZWDASC
|
8.7 | IC50 | 2 | — | |
BNSKTIACOBJLNV
|
8.7 | IC50 | 2 | — | |
CNQICKRUYCWBEH
|
8.7 | IC50 | 2 | — | |
FPWBFZKWSHLBDN
|
8.7 | IC50 | 2 | — | |
FRWXJFJBJPGDJM
|
8.7 | IC50 | 2 | — | |
JQEVJBGJLODSRH
|
8.7 | IC50 | 2 | — | |
KVTLEWCUMJPLAT
|
8.7 | IC50 | 2 | — | |
MCQBNMPALTYSES
|
8.7 | IC50 | 3 | — | |
QAGMCUQKCSBMNN
|
8.7 | IC50 | 2 | — | |
QPDAFPVNIOVXCG
|
8.7 | IC50 | 2 | — | |
SAWFCMBRIBWGDW
|
8.7 | IC50 | 2 | — | |
UBLXZGRGNPEZCR
|
8.7 | IC50 | 2 | — | |
VDYRZXYYQMMFJW
|
8.7 | Ki | 2 | — | |
VLGGZKWVODZVTH
|
8.7 | IC50 | 2 | — | |
WDARYLSSWBWVCU
|
8.7 | Ki | 49 | — | |
XLMFBNMLEHYJGT
|
8.7 | IC50 | 2 | — | |
YOXPJLZIOXCBGO
|
8.7 | IC50 | 4 | — | |
ZTBJDQDNHPHYGS
|
8.7 | IC50 | 7 | — | |
AWBKTMLYSSBTLA
|
8.7 | IC50 | 2 | — | |
UHTJASDMENLSNM
|
8.7 | IC50 | 2 | — | |
VUKPYAYVXNDTIK
|
8.7 | IC50 | 2 | — | |
NUSTUPPCTIUXFR
|
8.7 | IC50 | 2 | — | |
OEMBNPQPJNWALS
|
8.7 | Ki | 2 | — |