Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DCKFOWBHBAGPRR
|
9.1 | IC50 | 2 | — | |
OAMYGUPZJRNSAO
|
9.1 | IC50 | 2 | — | |
OMQBPULZTUQWCQ
|
9.1 | IC50 | 2 | — | |
REFWKLXNGKEUSQ
|
9.1 | IC50 | 2 | — | |
YAIFMBBJHJRLEF
|
9.1 | IC50 | 2 | — | |
AZLYARWHEXPDEW
|
9.1 | IC50 | 2 | — | |
WDKLHPSKXZBSDU
|
9.1 | IC50 | 2 | — | |
MUVYYVZAJFICKR
|
9.1 | IC50 | 2 | — | |
RKMCHMVWGYLCNL
|
9.1 | IC50 | 2 | — | |
RRARUIHCCITXRN
|
9.1 | IC50 | 2 | — | |
SUAFXIYFPRWWOY
|
9.1 | IC50 | 2 | — | |
YISMQBFJYDFMAL
|
9.1 | IC50 | 46 | — | |
GRFHEJWFORZSDZ
|
9.0 | IC50 | 2 | — | |
CJDWZZDGEKRVQD
|
9.0 | IC50 | 2 | — | |
FTUKZMZRGJAOKF
|
9.0 | IC50 | 2 | — | |
HSMAACWXVBSPJQ
|
9.0 | IC50 | 2 | — | |
JAWPAUHQCGKVGI
|
9.0 | IC50 | 2 | — | |
KACIGJBSABVNRF
|
9.0 | IC50 | 2 | — | |
KAWWWOFUKPBPQJ
|
9.0 | IC50 | 2 | — | |
LJQLCPYRTIQYAH
|
9.0 | IC50 | 2 | — | |
MKSLDODSQFIWOS
|
9.0 | IC50 | 2 | — | |
MQHAUPTVCAFIJM
|
9.0 | IC50 | 2 | — | |
MTJPSOHLRSAFBG
|
9.0 | IC50 | 3 | — | |
NGOKTEXAUPRBFP
|
9.0 | IC50 | 2 | — | |
OCIURXJNFVVOLL
|
9.0 | Ki | 3 | — | |
PBRPSSPCDCQDDX
|
9.0 | IC50 | 2 | — | |
QTSWVSMSXVPNMM
|
9.0 | IC50 | 2 | — | |
RCNSYAHCVQPUFD
|
9.0 | IC50 | 2 | — | |
XTIYMUSBVIPTLM
|
9.0 | IC50 | 2 | — | |
YSCICSHOCDXCAS
|
9.0 | IC50 | 2 | — | |
MAUISDMNPMEWQF
|
9.0 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
9.0 | IC50 | 408 | — | |
HCIIPWGEJOAVRZ
|
9.0 | IC50 | 2 | — | |
SIENFBFCGKUHOH
|
9.0 | IC50 | 2 | — | |
YCNNWSRSIAKLGS
|
9.0 | IC50 | 2 | — | |
HJTMKXREKMTLHV
|
8.9 | IC50 | 2 | — | |
BCJSNQZZTLHTAJ
|
8.9 | IC50 | 2 | — | |
CEEODNJYPPDYNU
|
8.9 | IC50 | 2 | — | |
FIICCIFGIGHGSR
|
8.9 | IC50 | 2 | — | |
FJEFZEKCTMBIHV
|
8.9 | IC50 | 2 | — | |
FPNYVINXEGJSCQ
|
8.9 | IC50 | 2 | — | |
HVEZIMSTJWKUGP
|
8.9 | IC50 | 2 | — | |
JEZPZXAMLGEGDI
|
8.9 | IC50 | 2 | — | |
RBUCEYWKPHIQNJ
|
8.9 | IC50 | 2 | — | |
RGOXMFMTFITUPB
|
8.9 | IC50 | 2 | — | |
CYRVCGFQHLNZFS
|
8.9 | Ki | 3 | — | |
ABEOBJODDVJCGS
|
8.9 | IC50 | 2 | — | |
ILGPOMJJRVJTEL
|
8.9 | IC50 | 2 | — | |
MXUZFINOYNQLNI
|
8.9 | IC50 | 2 | — | |
WHGWETKOANDIKB
|
8.9 | IC50 | 2 | — |