Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CKPNYQZEVSDPAZ
|
7.4 | Ki | 3 | — | |
FWLLRTWYRORQAU
|
7.4 | IC50 | 2 | — | |
IPEXHQGMTHOKQV
|
7.4 | Ki | 12 | — | |
JMGYGTNBCVNXBS
|
7.4 | Kd | 2 | — | |
LRMGXVOBRWPUFG
|
7.4 | IC50 | 2 | — | |
OPFXEPWUJYMTBG
|
7.4 | Kd | 2 | — | |
PCGOLHRVCCFRNK
|
7.4 | IC50 | 2 | — | |
DZSWYUCCPNQWOQ
|
7.4 | Ki | 4 | — | |
FWFHXPGGGOSSPF
|
7.4 | IC50 | 4 | — | |
HMHOSGROTWHBMJ
|
7.4 | IC50 | 2 | — | |
IWLDWBJBHVPZRX
|
7.4 | IC50 | 2 | — | |
RTAMKRDNYWGAPQ
|
7.4 | Ki | 4 | — | |
TXAKRIXEQQYHFA
|
7.4 | IC50 | 2 | — | |
FPOUNMXAICPJAF
|
7.4 | IC50 | 5 | — | |
JARCMQJIDMONGB
|
7.4 | IC50 | 2 | — | |
JMKFXBGMVLTISS
|
7.4 | IC50 | 2 | — | |
KSXFPISTQAHGIE
|
7.4 | IC50 | 4 | — | |
LZKXNZXRQFFQAH
|
7.4 | IC50 | 3 | — | |
SNQKPKFVSANKFP
|
7.4 | IC50 | 6 | — | |
WVZWFOGYDXWKPT
|
7.4 | Ki | 5 | Yes | |
ZGBVRRJEKGMKMJ
|
7.4 | IC50 | 2 | — | |
CNQGNADBGYCKKV
|
7.4 | Ki | 25 | — | |
CRKQBJZCCHKEGI
|
7.4 | Ki | 20 | — | |
DVOGQHRSJXYCBU
|
7.4 | IC50 | 2 | — | |
JXNMCDLXYWQTIW
|
7.4 | Ki | 13 | — | |
MIYRKQLKDQNUKZ
|
7.4 | Ki | 23 | — | |
MNEBTNXXCJJUOW
|
7.4 | Ki | 7 | — | |
NRZYTPAJGVTKIM
|
7.4 | Ki | 38 | — | |
NVRXTLZYXZNATH
|
7.4 | Ki | 47 | Yes | |
OEEGUWWPGAZRIJ
|
7.4 | Ki | 21 | — | |
OPOGDZANLATWGS
|
7.4 | Ki | 9 | — | |
PUQFAZBAPCKZKN
|
7.4 | IC50 | 5 | — | |
YOELNZYRZIJSGB
|
7.4 | IC50 | 3 | — | |
YVKVSKQNYIHXPX
|
7.4 | Ki | 7 | — | |
ZPVLRSVLOWVDJC
|
7.4 | Ki | 14 | — | |
ZRQXCQXWTLVASO
|
7.4 | Ki | 36 | — | |
BACMEOIVTBXRAB
|
7.4 | Ki | 3 | — | |
BIDMKVFDCZSPSM
|
7.4 | IC50 | 2 | — | |
GRFYVFBPFKGUQO
|
7.4 | Ki | 4 | — | |
LIJVDSICFNWJFS
|
7.4 | IC50 | 2 | — | |
PQVIVJUHYDLYRA
|
7.4 | IC50 | 6 | — | |
RSSVYLIGOHSPNV
|
7.4 | IC50 | 2 | — | |
YPLADSZZPCZLET
|
7.4 | Ki | 3 | — | |
KVYHBUCZXODPCA
|
7.4 | IC50 | 2 | — | |
WVKCMVMISLIFTD
|
7.4 | Ki | 4 | — | |
XVWAHNBWATXACB
|
7.4 | IC50 | 2 | — | |
HSOKLVXCJVXOOC
|
7.4 | IC50 | 2 | — | |
JPRMYFIQLOBNQF
|
7.4 | IC50 | 2 | — | |
LYLJYIZTSPUCNP
|
7.4 | IC50 | 2 | — | |
VPEQKGXRQZTIES
|
7.4 | IC50 | 6 | — |