Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VZOXJFOAJQVTTK
|
7.5 | IC50 | 4 | — | |
YLRZEPPAUZLMKR
|
7.5 | IC50 | 7 | — | |
ZHDPMPLGMKQADI
|
7.5 | IC50 | 3 | — | |
ZKZXNDJNWUTGDK
|
7.5 | Kd | 9 | — | |
BHSOPYVVEZFHDB
|
7.5 | Ki | 25 | Yes | |
BPNUQXPIQBZCMR
|
7.5 | Ki | 60 | — | |
CHADTINFLWZSKR
|
7.5 | Ki | 26 | — | |
DPAPGNJIIHRZFH
|
7.5 | IC50 | 2 | — | |
FDBPGAHVEGEARY
|
7.5 | Ki | 19 | — | |
JWQOJVOKBAAAAR
|
7.5 | Ki | 29 | — | |
KNVOICXEDILAGT
|
7.5 | Ki | 17 | — | |
LPILBMJJRGTKOQ
|
7.5 | Ki | 27 | — | |
PWIKZIKRKUUHRB
|
7.5 | Ki | 9 | — | |
PWPNYABQEOGNNC
|
7.5 | IC50 | 4 | — | |
PYXQMJSGJIJHJT
|
7.5 | Ki | 28 | — | |
RURMYELSAFPPJN
|
7.5 | IC50 | 2 | — | |
RVZNRIUKOGKCJM
|
7.5 | IC50 | 2 | — | |
SRONQUHCRFZABC
|
7.5 | Ki | 28 | — | |
UPPGGRZNGRFDAU
|
7.5 | Ki | 21 | — | |
VVEGARMQKNYDID
|
7.5 | Ki | 24 | — | |
WNMXOXGXHRHBLO
|
7.5 | Ki | 4 | — | |
WPHKIQPVPYJNAX
|
7.5 | Ki | 81 | — | |
XXSPHNFKLDJDAK
|
7.5 | Ki | 26 | — | |
BMMXFLCCJJRAMC
|
7.5 | Ki | 3 | — | |
OORBXCUUHIIWJV
|
7.5 | IC50 | 2 | — | |
WXJWGWJEPVCGSC
|
7.5 | IC50 | 3 | — | |
YQZUYMIRRIDTAO
|
7.5 | IC50 | 2 | — | |
NYBYRRGDBUNJMV
|
7.5 | IC50 | 2 | — | |
VGJUQZDOYBBMLP
|
7.5 | IC50 | 2 | — | |
XVWAHNBWATXACB
|
7.5 | IC50 | 2 | — | |
ZSRGQQNNHDFZKU
|
7.5 | IC50 | 2 | — | |
GWYVKALUKYVOPI
|
7.5 | IC50 | 4 | — | |
HUCQMRYDVBGPJG
|
7.5 | IC50 | 2 | — | |
JQLUBNSKBPGUSU
|
7.5 | IC50 | 2 | — | |
SIFDVGOSDLKPGX
|
7.5 | IC50 | 2 | — | |
VZOXJFOAJQVTTK
|
7.5 | IC50 | 2 | — | |
WTLKHNCRMWMEPP
|
7.5 | IC50 | 2 | — | |
ZANIGAVBLOXUNT
|
7.5 | IC50 | 2 | — | |
ZNHSSCHACDGIFB
|
7.5 | IC50 | 2 | — | |
FMPMBLNIHLMPOW
|
7.5 | IC50 | 2 | — | |
INIRSEZIKNVYNU
|
7.5 | IC50 | 2 | — | |
JFOPDXJGAOLMTK
|
7.5 | IC50 | 2 | — | |
OERDIQQYFKMTRX
|
7.5 | IC50 | 2 | — | |
OLKPRWFWMGMGCJ
|
7.5 | Ki | 4 | — | |
PUGDUBQQBUJNPW
|
7.5 | IC50 | 2 | — | |
VTSLKIKDRBEGHX
|
7.5 | Ki | 3 | — | |
BZMYCBISXGQOME
|
7.5 | IC50 | 2 | — | |
LWPFVYFLCQBXTN
|
7.5 | IC50 | 2 | — | |
AQFNYWZXUKXWDN
|
7.4 | IC50 | 2 | — | |
AQMDNGFFSSWQGE
|
7.4 | IC50 | 2 | — |