Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
TUMVBSIBURICOB
|
7.6 | IC50 | 2 | — | |
WZSVRUCBLPTNFX
|
7.6 | Ki | 4 | — | |
ZGGIYFOLDBTZIL
|
7.6 | Ki | 27 | — | |
JDIAOFCAAPMAGG
|
7.6 | Ki | 4 | — | |
BJLOBSMGZUMYOP
|
7.6 | IC50 | 8 | — | |
BKOIAFICAZVOHM
|
7.6 | IC50 | 2 | — | |
HZBPSQIDFQPUKG
|
7.6 | IC50 | 2 | — | |
IIRWNGPLJQXWFJ
|
7.6 | Kd | 21 | — | |
ILVOKNGCZRZTJJ
|
7.6 | IC50 | 2 | — | |
IQDPKFXHMNEJFH
|
7.6 | IC50 | 2 | — | |
OBRQLJITIRIMLQ
|
7.6 | IC50 | 11 | — | |
QNLPOUSEBULSGB
|
7.6 | IC50 | 2 | — | |
HSRYETVWRVWJQQ
|
7.6 | IC50 | 6 | — | |
MBRVCJRFWYHVHE
|
7.6 | IC50 | 2 | — | |
PNLQOSABVUZYHX
|
7.6 | IC50 | 2 | — | |
QBWKZDBFMHLSHV
|
7.6 | IC50 | 2 | — | |
QCMDWRLNDWXISF
|
7.6 | IC50 | 2 | — | |
QMERQFWNSUWTJZ
|
7.6 | IC50 | 2 | — | |
SHZBLRCXYAENEO
|
7.6 | IC50 | 2 | — | |
VBBARCMTJPDGFK
|
7.6 | IC50 | 2 | — | |
LIUKLYUNBUVVON
|
7.6 | IC50 | 2 | — | |
RKGXRJNCSPXVMJ
|
7.6 | IC50 | 2 | — | |
VEVFWVYCXXMKPF
|
7.6 | IC50 | 2 | — | |
BBXXHBWFOCUGJH
|
7.5 | IC50 | 2 | — | |
PGUYFODZDWZZGB
|
7.5 | IC50 | 2 | — | |
URKCEACRGZFFGD
|
7.5 | IC50 | 2 | — | |
UTXFYQOYXIBPAU
|
7.5 | IC50 | 2 | — | |
WKWGFJFNCXAUEX
|
7.5 | Ki | 14 | Yes | |
YYQWLNWVYQGLHK
|
7.5 | IC50 | 2 | — | |
ZARZTVDSAHZYSP
|
7.5 | IC50 | 2 | — | |
ALIDJEXJLBEKJC
|
7.5 | IC50 | 2 | — | |
GASKYZOWZMIJOP
|
7.5 | Ki | 4 | — | |
GDKARAKSWPBMFG
|
7.5 | IC50 | 2 | — | |
GLBZPQCZKNSQEB
|
7.5 | IC50 | 2 | — | |
OATPNKANSMGAAO
|
7.5 | IC50 | 2 | — | |
RTCFKJVSDGLJAM
|
7.5 | Ki | 3 | — | |
VPJJIOPOZCPBMR
|
7.5 | IC50 | 2 | — | |
XUGHJQRTNYRFEP
|
7.5 | IC50 | 2 | — | |
AELUNVGWCJWFQX
|
7.5 | IC50 | 2 | — | |
FBOBDONRPNTRJB
|
7.5 | IC50 | 2 | — | |
JUDDACYFKPQFQQ
|
7.5 | Ki | 4 | — | |
KDBDEJFJWFXSGJ
|
7.5 | Ki | 4 | — | |
LBRNKEMUALCIHZ
|
7.5 | Kd | 4 | — | |
OQORIVHBMBWOAH
|
7.5 | IC50 | 2 | — | |
OTQBWQLVWMNWBE
|
7.5 | IC50 | 2 | — | |
PTROMZWPUXNMAK
|
7.5 | IC50 | 2 | — | |
RAFDCMBISGTRKN
|
7.5 | IC50 | 2 | — | |
VHZNRUKXHPDXMR
|
7.5 | Ki | 4 | — | |
ZSRGQQNNHDFZKU
|
7.5 | IC50 | 2 | — | |
LFPUNHMXMCZMLZ
|
7.5 | IC50 | 3 | — |