Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QSKQVZWVLOIIEV
|
7.7 | IC50 | 4 | — | |
SKYALJGMRAGHEN
|
7.7 | IC50 | 2 | — | |
VFGWASLDLFTQPZ
|
7.7 | Ki | 6 | Yes | |
ISRFXEQOQGZVMK
|
7.7 | IC50 | 2 | — | |
JXPHKZGTRJJKLA
|
7.7 | IC50 | 3 | — | |
LUJABRZNRKRZRI
|
7.7 | Ki | 2 | — | |
ORTCEQUUKXOFAE
|
7.7 | IC50 | 2 | — | |
VKORCHLUUJGKEE
|
7.7 | Ki | 3 | — | |
ZTDZUGXYUUIFQW
|
7.7 | IC50 | 2 | — | |
BERZRFJWHSXBCR
|
7.7 | Ki | 7 | — | |
BXVVJBRCXPFGAH
|
7.7 | IC50 | 2 | — | |
CUJPUWSIKWTBRS
|
7.7 | Ki | 3 | — | |
DBLHWYWZXQGUJM
|
7.7 | IC50 | 2 | — | |
DNUAUADEIBLJGT
|
7.7 | IC50 | 2 | — | |
HCDNKTJUMCHZJG
|
7.7 | IC50 | 2 | — | |
KTDHNPKPSLZNRH
|
7.7 | Ki | 4 | — | |
LOMGAGWJYPGDLT
|
7.7 | Ki | 8 | — | |
OKRVQPLFYBUDOF
|
7.7 | IC50 | 2 | — | |
PCKDJQQSQGGVGF
|
7.7 | IC50 | 3 | — | |
PQGVJYYWZHMBEY
|
7.7 | IC50 | 2 | — | |
RFBPWKMQWSIPEO
|
7.7 | Ki | 28 | — | |
RNAFKLYSCSXHPD
|
7.7 | IC50 | 2 | — | |
UMTWTCVTRDYHQQ
|
7.7 | Ki | 56 | — | |
UOOFSEUSROQBBP
|
7.7 | Ki | 8 | — | |
VEXYJVKMGKPGRV
|
7.7 | Ki | 6 | — | |
VYACUCWGDYRIAG
|
7.7 | Ki | 7 | — | |
XJSFDMGICAWQFS
|
7.7 | Ki | 60 | — | |
XKLOPDYWVXDVPR
|
7.7 | IC50 | 2 | — | |
YJBNTRQKJQHMTM
|
7.7 | Ki | 11 | — | |
ZPQGWIWZWZNROO
|
7.7 | IC50 | 6 | — | |
ZYTFPHRVOZXPGZ
|
7.7 | Ki | 30 | — | |
DVHXGAIYRHHWGU
|
7.7 | IC50 | 2 | — | |
GYMRIGZBUYFIEU
|
7.7 | IC50 | 7 | — | |
HWGXVQXOZZVGKP
|
7.7 | Ki | 3 | — | |
JBLPUDJLELBRHC
|
7.7 | IC50 | 9 | — | |
LDBFNMYQAWGPMG
|
7.7 | IC50 | 2 | — | |
RHDFHWYPNJABRA
|
7.7 | IC50 | 2 | — | |
UTPDQPQSXIPZQG
|
7.7 | IC50 | 2 | — | |
UZXCLKOZEMNTRB
|
7.7 | Ki | 3 | — | |
XFGKKABMAJVJQB
|
7.7 | IC50 | 2 | — | |
XQDLITNOVPCUMD
|
7.7 | IC50 | 2 | — | |
CIXVBMOGRAAGGW
|
7.7 | IC50 | 2 | — | |
DGPJCEDEJQDQFA
|
7.7 | Ki | 3 | — | |
JILSPXHZRNLZHV
|
7.7 | IC50 | 2 | — | |
PKMQNJPAXXVFEE
|
7.7 | IC50 | 2 | — | |
CGXOKVWAHQLXGW
|
7.7 | IC50 | 2 | — | |
COZSHMVZWUUCPG
|
7.7 | IC50 | 2 | — | |
CYLSXYAMTHBWRF
|
7.7 | Ki | 4 | — | |
GRUQPKMQXSFMIX
|
7.7 | IC50 | 2 | — | |
KNLNXBWYAOCAOU
|
7.7 | IC50 | 2 | — |