Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SGHXFHRRWFLILP
|
7.8 | Ki | 29 | — | |
UCJIXVPTONWDEH
|
7.8 | IC50 | 3 | — | |
WCYUWOYDOXQVSN
|
7.8 | IC50 | 2 | — | |
XFHCSNRQFQRLHZ
|
7.8 | Ki | 12 | Yes | |
XNWKXXIGSPPPBH
|
7.8 | Ki | 31 | — | |
XOVPCPRZRHQFBI
|
7.8 | Ki | 15 | — | |
APAMRVUFSPSIFZ
|
7.8 | IC50 | 2 | — | |
PGAUIFVQAJTKKJ
|
7.8 | IC50 | 2 | — | |
YVTWDJQRSGSDSG
|
7.8 | IC50 | 2 | — | |
NTVGZILGUNKNME
|
7.8 | IC50 | 2 | — | |
SVEDSLIXPDIZCB
|
7.8 | IC50 | 2 | — | |
JPHMTCGRECDTPW
|
7.8 | IC50 | 2 | — | |
JQPFBPKZRBMCCY
|
7.8 | IC50 | 2 | — | |
KMIKGPNXOFBRHM
|
7.8 | IC50 | 2 | — | |
LYJKMVFAIXOQLE
|
7.8 | IC50 | 9 | — | |
OGPFJRNUCSCJQP
|
7.8 | IC50 | 2 | — | |
OQORIVHBMBWOAH
|
7.8 | IC50 | 2 | — | |
PKPFORXTLXAABS
|
7.8 | IC50 | 2 | — | |
TXBFBOHWKUHOLB
|
7.8 | IC50 | 2 | — | |
XNSRBVPDGAZWDJ
|
7.8 | IC50 | 7 | — | |
YCKSAEMFWYPXDF
|
7.8 | IC50 | 2 | — | |
ZCCPLJOKGAACRT
|
7.8 | Kd | 599 | — | |
BMMXFLCCJJRAMC
|
7.8 | Ki | 4 | — | |
MAEMMKFBENFITQ
|
7.8 | IC50 | 2 | — | |
PUDPIQFNZNNYGT
|
7.8 | IC50 | 3 | — | |
RJMZRJDWOXEUNY
|
7.8 | IC50 | 2 | — | |
SYAFKJOXGPOOAP
|
7.8 | IC50 | 2 | — | |
FCKYQPCANANIBR
|
7.7 | IC50 | 2 | — | |
FJUYJNSUOZJBSU
|
7.7 | IC50 | 2 | — | |
GEPQSMPOMLNHIV
|
7.7 | IC50 | 2 | — | |
HFSFYDXPXKXDTB
|
7.7 | IC50 | 2 | — | |
KLXDOPUNBJJHGO
|
7.7 | IC50 | 2 | — | |
OFDBLIAMQPCXKD
|
7.7 | Ki | 3 | — | |
OTNWPJUPTWXBRM
|
7.7 | IC50 | 2 | — | |
VIWMCGWPKWDOBH
|
7.7 | IC50 | 2 | — | |
VSVKFEMFAYXZKR
|
7.7 | Ki | 14 | Yes | |
WZZSMRPQWMDPQL
|
7.7 | IC50 | 2 | — | |
XEBSFQDAOYDIMU
|
7.7 | Ki | 2 | — | |
YETWTPHBLHMHNX
|
7.7 | IC50 | 2 | — | |
ZUORJMYVIBRGPQ
|
7.7 | IC50 | 2 | — | |
ILUJLOCSNMCDBW
|
7.7 | Ki | 3 | — | |
MTBXPHFYMJZJAP
|
7.7 | IC50 | 2 | — | |
ACSFOKQSDKYSPD
|
7.7 | IC50 | 2 | — | |
AMBHUZIJUSXSQJ
|
7.7 | IC50 | 2 | — | |
DRMNJKORTHCIDQ
|
7.7 | IC50 | 2 | — | |
DWFFOTBUFHRBSA
|
7.7 | IC50 | 2 | — | |
GVEIJKANJLOMJH
|
7.7 | IC50 | 2 | — | |
KCHJGCRFBMOASW
|
7.7 | IC50 | 2 | — | |
MXHZTZIKTRBFFS
|
7.7 | IC50 | 2 | — | |
NMHHYBNZLFASKW
|
7.7 | IC50 | 2 | — |