Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HRCKLYFDWWYCLS
|
7.8 | Ki | 2 | — | |
JEFRBITWIOXMNQ
|
7.8 | IC50 | 6 | — | |
LQRGVYJVTGFQPC
|
7.8 | IC50 | 2 | — | |
LWMGXEAOAQXWQY
|
7.8 | IC50 | 2 | — | |
OQGZWUQINVEKPB
|
7.8 | IC50 | 2 | — | |
PILIWAPJQLCXKO
|
7.8 | IC50 | 2 | — | |
RDSJJFGKRCBYRH
|
7.8 | IC50 | 4 | — | |
RENUXSODWRPLNA
|
7.8 | IC50 | 2 | — | |
SDZRYLPROGBZMB
|
7.8 | IC50 | 8 | — | |
YNXRZSCAJYMWMX
|
7.8 | IC50 | 2 | — | |
ZEGZREPARJMRTR
|
7.8 | IC50 | 2 | — | |
SFPKABLFLBXVRZ
|
7.8 | Ki | 3 | — | |
IBWDJNVWCDSMLK
|
7.8 | IC50 | 2 | — | |
QSWXBXSDEQWIGI
|
7.8 | IC50 | 2 | — | |
RQJNDHYSIAYHOI
|
7.8 | IC50 | 2 | — | |
FRPJSZRAPBBGTE
|
7.8 | IC50 | 2 | — | |
IIOMFEOXTRHVDM
|
7.8 | IC50 | 2 | — | |
KFCCRAZFDCBPNZ
|
7.8 | IC50 | 2 | — | |
MHGGVTPOFCDMQY
|
7.8 | IC50 | 2 | — | |
ODXYBJZMEVDVSA
|
7.8 | Ki | 4 | — | |
PZAYZTYHHVPMFG
|
7.8 | IC50 | 2 | — | |
QSNGYDDKKPBORF
|
7.8 | IC50 | 2 | — | |
RQKKDDPVAKBRAI
|
7.8 | IC50 | 2 | — | |
SLODBPIAZZPOFN
|
7.8 | IC50 | 7 | — | |
SMFMKNYLBVEQGI
|
7.8 | IC50 | 2 | — | |
VAMDLIMJLAPZGX
|
7.8 | IC50 | 2 | — | |
WEGHHPFXCHFJFR
|
7.8 | Ki | 3 | — | |
ZDIVXJMVURCVPS
|
7.8 | IC50 | 2 | — | |
ZTXPZKBYVPEULR
|
7.8 | IC50 | 3 | — | |
FWVPDHPTJUHLCW
|
7.8 | IC50 | 2 | — | |
SHMZVLGXEVPHCQ
|
7.8 | Ki | 4 | — | |
BEPHQLKTGFSXCX
|
7.8 | IC50 | 2 | — | |
CJTWJAYLKYVKRD
|
7.8 | IC50 | 2 | — | |
CZYVRBPRTGDQLG
|
7.8 | IC50 | 2 | — | |
DZKIUHYWWRPLSM
|
7.8 | IC50 | 2 | — | |
FATSBSNRASYTNE
|
7.8 | IC50 | 2 | — | |
FNAPEKSJRDLQRC
|
7.8 | Ki | 4 | — | |
FUSGHFKTWQRWPV
|
7.8 | Ki | 4 | — | |
HFBCKXXEXNDPEJ
|
7.8 | IC50 | 5 | — | |
KCKXYZOBGBJZEG
|
7.8 | Ki | 36 | — | |
KHGPYYFCIAISBU
|
7.8 | Ki | 31 | — | |
KTWBYGUSEYSRND
|
7.8 | Ki | 28 | — | |
LYLJYIZTSPUCNP
|
7.8 | IC50 | 2 | — | |
OAPYGPMKZPIRRM
|
7.8 | IC50 | 2 | — | |
OPLHMHMCXQXEQG
|
7.8 | Ki | 10 | — | |
OSVUGUHRKMMBSE
|
7.8 | Kd | 170 | — | |
PTZQSGFNHIVQKV
|
7.8 | Ki | 8 | — | |
QNIZYMHQGXFAMH
|
7.8 | IC50 | 2 | — | |
RKDYDLMULRETNX
|
7.8 | Ki | 8 | — | |
SBMZASWPEBFVCG
|
7.8 | IC50 | 2 | — |