Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KUKQBSNMNWQADK
|
8.0 | IC50 | 2 | — | |
LRGRNIANIHKGHI
|
8.0 | IC50 | 2 | — | |
PWWJBQFUGNBNDJ
|
8.0 | IC50 | 2 | — | |
AQDWLHMFJHACCX
|
8.0 | Ki | 8 | — | |
DQPYZHUAILXFJI
|
8.0 | Ki | 27 | — | |
DWTNLZZEPSCAIH
|
8.0 | IC50 | 2 | — | |
FHVDVOWXUDMQFB
|
8.0 | IC50 | 2 | — | |
FYKKNMQWIMTCOO
|
8.0 | IC50 | 2 | — | |
GLXJGZLTPLOTJM
|
8.0 | IC50 | 4 | — | |
GWJHMRBQEUHFOC
|
8.0 | Ki | 42 | — | |
HTROFVQKJODSCL
|
8.0 | IC50 | 11 | — | |
JBXUKWIGBDQLCO
|
8.0 | IC50 | 7 | — | |
JNMRJWAHYXSUQE
|
8.0 | IC50 | 2 | — | |
KRZMKLFPGBUXGH
|
8.0 | IC50 | 3 | — | |
NIUJTENHSPPCKO
|
8.0 | Ki | 9 | — | |
NVDYRDZHCINQQB
|
8.0 | IC50 | 3 | — | |
ODUYVHAFJTXMAF
|
8.0 | Ki | 3 | — | |
QEWSTOOMTBAUAG
|
8.0 | Ki | 17 | — | |
SPINQLSJUQMOTF
|
8.0 | IC50 | 2 | — | |
SWHUIIODYNUMNO
|
8.0 | IC50 | 2 | — | |
UGPDNKHGAAKZIR
|
8.0 | IC50 | 2 | — | |
XFWUTMHVDGPWLH
|
8.0 | Ki | 75 | — | |
AEVCWYWUPQHFFI
|
8.0 | IC50 | 2 | — | |
BFSFWCMZFSXSOK
|
8.0 | Ki | 4 | — | |
DYMMJEIVULXUAB
|
8.0 | IC50 | 2 | — | |
HUXNQLSQBYWWAS
|
8.0 | IC50 | 2 | — | |
QTMFCQXLQBJZQU
|
8.0 | IC50 | 4 | — | |
UNLKQQRQHFRCKR
|
8.0 | IC50 | 2 | — | |
VUKPYAYVXNDTIK
|
8.0 | IC50 | 2 | — | |
AFRRRQARLYDLTJ
|
8.0 | IC50 | 2 | — | |
APPRZRMVUBRYNF
|
8.0 | IC50 | 2 | — | |
BDCUKYUIVYKXCQ
|
8.0 | IC50 | 2 | — | |
FXDUJKSFLDJRPN
|
8.0 | IC50 | 2 | — | |
GDWGDFCIZLJSSE
|
8.0 | IC50 | 2 | — | |
IGTNWPHKEMOAGM
|
8.0 | IC50 | 2 | — | |
IJASYRWFAWXBTH
|
8.0 | IC50 | 2 | — | |
IVWXFGRLNHCKNV
|
8.0 | IC50 | 2 | — | |
JQCWNEXLKSGUJQ
|
8.0 | IC50 | 3 | — | |
KIEIVVQNVJKJFB
|
8.0 | IC50 | 2 | — | |
KSKYRXFKNPXFGI
|
8.0 | IC50 | 6 | — | |
LSMZQWHWUVFUIF
|
8.0 | IC50 | 2 | — | |
ONZAMBWLADUDER
|
8.0 | IC50 | 2 | — | |
PYMFRFRTGCCYGT
|
8.0 | IC50 | 2 | — | |
RBJUUZRKUCSSRS
|
8.0 | IC50 | 6 | — | |
RVLBWZZSHLQKAN
|
8.0 | IC50 | 2 | — | |
UMQNZSBIZJEBSD
|
8.0 | IC50 | 6 | — | |
YUASGVJCKFLDMF
|
8.0 | IC50 | 2 | — | |
CDAZONRYNUZNMV
|
7.9 | IC50 | 2 | — | |
CWKUJWGURSJFTK
|
7.9 | IC50 | 2 | — | |
LBESRPHKXLREQJ
|
7.9 | IC50 | 2 | — |