Target Details
| UniProt AC | O75116 |
|---|---|
| Gene Symbol | ROCK2 |
| Protein Name | Rho-associated protein kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,696
- Clinical molecules 39
- Avg pChEMBL 7.47
KEGG Pathways (23)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,696)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
PHZQLNMARSMWBL
|
10.7 | Kd | 2 | — | |
WTVWWCQGJWIMBF
|
9.9 | IC50 | 3 | — | |
WPOIOKJTVWXYEA
|
9.7 | IC50 | 2 | — | |
LTXBFJFJUIJOQE
|
9.7 | Ki | 3 | — | |
DPGQPPYMTLBAIO
|
9.6 | IC50 | 2 | — | |
KQDDDWVLLDDHOF
|
9.5 | IC50 | 2 | — | |
PDOWPLWTKJLFMU
|
9.5 | IC50 | 2 | — | |
OVQFXLFWQAYHOI
|
9.5 | IC50 | 2 | — | |
YGZVCRLWTNQONT
|
9.5 | IC50 | 2 | — | |
GKCYBFUIFHJFSO
|
9.5 | IC50 | 2 | — | |
GPERPWCLYBHCRW
|
9.4 | IC50 | 2 | — | |
SJHKIJFJOUJEAT
|
9.4 | IC50 | 2 | — | |
ZEVPNNBHHMHIGE
|
9.4 | IC50 | 2 | — | |
JUCBZNHHQKCEMY
|
9.4 | IC50 | 2 | — | |
JWVWCAKTWBMEPU
|
9.4 | IC50 | 2 | — | |
OMVMGDVRMSCTFN
|
9.4 | IC50 | 3 | — | |
XEXZHTMEICBSBN
|
9.4 | IC50 | 2 | — | |
WHVMMFVGEVMVIT
|
9.3 | IC50 | 2 | — | |
FBAPHDWTBAGCKW
|
9.3 | IC50 | 3 | — | |
LUFXPAXGLVEWPI
|
9.3 | Ki | 2 | — | |
CPEWUKOGQOXNMY
|
9.3 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
9.3 | Ki | 118 | — | |
IHPZTIFVUUEGSN
|
9.3 | IC50 | 2 | — | |
QFHANDBITKFWTC
|
9.3 | IC50 | 7 | — | |
CKUIXZUZIPIFQX
|
9.3 | IC50 | 2 | — | |
DVRUQNLSZFAFOD
|
9.3 | IC50 | 2 | — | |
GSOQMEARYDGDSU
|
9.3 | IC50 | 2 | — | |
AEFIGQFODUVLFR
|
9.3 | IC50 | 2 | — | |
TUQZDIZIVRTIGP
|
9.3 | IC50 | 2 | — | |
HWVIELIZINHJJY
|
9.3 | IC50 | 2 | — | |
XESDIZSUBGMYNC
|
9.2 | IC50 | 2 | — | |
PHWHNHYZZNJPLB
|
9.2 | Ki | 16 | — | |
ABADVZLOYZQQIW
|
9.2 | IC50 | 2 | — | |
HIVOASQRESOTMJ
|
9.2 | IC50 | 2 | — | |
MTZPPYMBIBCZBH
|
9.2 | IC50 | 2 | — | |
SGJZTWNMDXDAKV
|
9.2 | IC50 | 2 | — | |
ZAMBLNKLSSPUQI
|
9.2 | IC50 | 2 | — | |
ROFMCPHQNWGXGE
|
9.2 | IC50 | 3 | — | |
UANOWIUKWGKWOC
|
9.2 | IC50 | 2 | — | |
DVTKMLJDBJSXHF
|
9.1 | IC50 | 2 | — | |
IMUQMJFWSHDHRX
|
9.1 | IC50 | 2 | — | |
WPXXNWXNNZASGI
|
9.1 | IC50 | 2 | — | |
GKKIGWFSHHJSMM
|
9.1 | IC50 | 2 | — | |
PMXKUMCLYSFPJB
|
9.1 | IC50 | 4 | — | |
WTZMCUOBQPTERK
|
9.1 | IC50 | 2 | — | |
YKJXZODWOQJHCQ
|
9.1 | IC50 | 2 | — | |
BWJHMGCCCMRFBU
|
9.1 | IC50 | 2 | — | |
DBKFQGAJZUOGMZ
|
9.1 | IC50 | 2 | — | |
LWBVQGQTGHIORB
|
9.1 | IC50 | 2 | — | |
JKLZPEFCFKLVKA
|
9.1 | IC50 | 2 | — |