Target Details
| UniProt AC | O60674 |
|---|---|
| Gene Symbol | JAK2 |
| Protein Name | Tyrosine-protein kinase JAK2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 10,545
- Clinical molecules 78
- Avg pChEMBL 7.81
KEGG Pathways (26)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Herpes simplex virus 1 infection
- Hormone signaling
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- Necroptosis
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prolactin signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toxoplasmosis
- Tuberculosis
Associated Diseases (9)
Active Molecules (10,545)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QBRHKUPULOMUFA
|
10.0 | Ki | 2 | — | |
RSRGZFZZRNZHGT
|
10.0 | IC50 | 2 | — | |
SJKHRTQCLRTCJI
|
10.0 | Ki | 2 | — | |
UTJDSHPTWRTXEG
|
10.0 | Ki | 2 | — | |
WISDJQVWPWYDHB
|
10.0 | IC50 | 2 | — | |
WMHADRQOGWVVLT
|
10.0 | Ki | 2 | — | |
ZETDVJIEROUNIC
|
10.0 | Ki | 2 | — | |
FUEIJOICQSRCFR
|
9.9 | IC50 | 4 | — | |
IEZRZUHSKFJPQY
|
9.9 | IC50 | 2 | — | |
IKOVYVZQLUHKRJ
|
9.9 | IC50 | 2 | — | |
LWEXBVKOJGMKLH
|
9.9 | IC50 | 4 | — | |
NWGRIRNDHVPEDQ
|
9.9 | IC50 | 4 | — | |
UAYHCEIKWIDIQO
|
9.9 | IC50 | 4 | — | |
UCALNVLMEPQUKV
|
9.9 | IC50 | 3 | — | |
VEDSSZUWHRJVAK
|
9.9 | IC50 | 2 | — | |
CMGIHZWIMOWJLB
|
9.9 | IC50 | 2 | — | |
FIKPXCOQUIZNHB
|
9.9 | Kd | 2 | — | |
FPYHDWUSAOFILC
|
9.9 | IC50 | 2 | — | |
GKVPWYDPEFVJEW
|
9.9 | IC50 | 2 | — | |
KRGJWBAMLRBENV
|
9.9 | IC50 | 2 | — | |
LEPDKKSIRCQPDJ
|
9.9 | IC50 | 2 | — | |
MMYOAIHHDKRIIT
|
9.9 | Ki | 2 | — | |
MVBHRZHKVRTKFA
|
9.9 | Ki | 2 | — | |
OFBHCLJFUYEAII
|
9.9 | Ki | 2 | — | |
QIUJVZGYISFYIX
|
9.9 | IC50 | 3 | — | |
QSYHDKBFWRCHKW
|
9.9 | Ki | 2 | — | |
QWFFOELVGDLHSA
|
9.9 | IC50 | 2 | — | |
VOEVWNYDAOBKRA
|
9.9 | IC50 | 2 | — | |
WTMPJYUJIMBLLR
|
9.9 | Ki | 2 | — | |
XKHCXATWRJFTEP
|
9.9 | Ki | 2 | — | |
NRYOXXMMQVNECT
|
9.9 | IC50 | 4 | — | |
UPKJSCTVENSCCN
|
9.9 | IC50 | 2 | — | |
LUPCHAFIKZSOOK
|
9.9 | Ki | 15 | — | |
DRGWCQMLFFCEJR
|
9.9 | Ki | 2 | — | |
DUODMCPFBKQMHD
|
9.9 | Ki | 2 | — | |
JWHFFSSHJCWKJU
|
9.9 | IC50 | 2 | — | |
KPCROHRIDAGSMC
|
9.9 | Ki | 2 | — | |
KZRSAVXBPQERQP
|
9.9 | Ki | 2 | — | |
LCHGXWXNRFSDDK
|
9.9 | IC50 | 2 | — | |
MBBKLMHHKNIWTK
|
9.9 | Ki | 2 | — | |
MGOMILIXHSDJNQ
|
9.9 | Ki | 2 | — | |
RPBFJNXYGYUMOI
|
9.9 | Ki | 2 | — | |
SCFXRVXGXNBVDI
|
9.9 | IC50 | 3 | — | |
SRPNJZWTHJDMHK
|
9.9 | IC50 | 3 | — | |
TWNHDYRZRRWJBV
|
9.9 | IC50 | 2 | — | |
VCGGAOKSAYJBFQ
|
9.9 | Ki | 2 | — | |
ZGTGVGIFPHRGJP
|
9.9 | IC50 | 2 | — | |
ZSEHWWSPEHLJHF
|
9.9 | Ki | 2 | — | |
KRHZDZQVASLABQ
|
9.9 | IC50 | 2 | — | |
NDKIFWJDZDKTCC
|
9.9 | IC50 | 4 | — |